Patents by Inventor Kamal El Bissati

Kamal El Bissati has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds and methods for treating, detecting, and identifying compounds to treat apicomplexan parasitic diseases
    Patent number: 11964944
    Abstract: Disclosed herein are novel compounds for treating apicomplexan parasite related disorders, methods for their use; cell line and non-human animal models of the dormant parasite phenotype and methods for their use in identifying new drugs to treat apicomplexan parasite related disorders, and biomarkers to identify disease due to the parasite and its response to treatment.
    Type: Grant
    Filed: June 2, 2022
    Date of Patent: April 23, 2024
    Assignees: The University of Chicago, J. Craig Venter Institute, Inc., The University of Sheffield, Institute for Systems Biology, The University of Leeds, The University of Strathclyde, The Government of the United States
    Inventors: Rima McLeod, Martin McPhillie, Colin W. G. Fishwick, Hernan Alejandro Lorenzi, Kai Wang, Taek-Kyun Kim, Yong Zhou, Leroy E. Hood, Ying Zhou, Kamal El Bissati, Mark Hickman, QiGui Li, Craig Roberts
  • Compounds and Methods for Treating, Detecting, and Identifying Compounds to Treat Apicomplexan Parasitic Diseases
    Publication number: 20230140413
    Abstract: Disclosed herein are novel compounds for treating apicomplexan parasite related disorders, methods for their use; cell line and non-human animal models of the dormant parasite phenotype and methods for their use in identifying new drugs to treat apicomplexan parasite related disorders, and biomarkers to identify disease due to the parasite and its response to treatment.
    Type: Application
    Filed: June 2, 2022
    Publication date: May 4, 2023
    Inventors: Rima McLeod, Martin McPhillie, Colin W.G. Fishwick, Hernan Alejandro Lorenzi, Kai Wang, Taek-Kyun Kim, Yong Zhou, Leroy E. Hood, Ying Zhou, Kamal El Bissati, Mark Hickman, QiGui Li, Craig Roberts
  • Compounds and methods for treating, detecting, and identifying compounds to treat apicomplexan parasitic diseases
    Patent number: 11414385
    Abstract: Disclosed herein; are novel compounds for treating apicomplexan parasite related disorders, methods for their use; cell line and non-human animal models of the dormant parasite phenotype and methods for their use in identifying new drugs to treat apicomplexan parasite related disorders, and biomarkers to identify disease due to the parasite and its response to treatment.
    Type: Grant
    Filed: December 20, 2016
    Date of Patent: August 16, 2022
    Inventors: Rima McLeod, Martin McPhillie, Colin W. G. Fishwick, Hernan Alejandro Lorenzi, Kai Wang, Taek-Kyun Kim, Yong Zhou, Leroy E. Hood, Ying Zhou, Kamal El Bissati, Mark Hickman, QiGui Li, Craig Roberts
  • TOXOPLASMA GONDII VACCINES AND THEIR USE
    Publication number: 20220202921
    Abstract: Disclosed herein are polynucleotides encoding multi-epitope polypeptides and assemblies thereof, and their use for treating or limiting Toxoplasma gondii infection.
    Type: Application
    Filed: March 11, 2022
    Publication date: June 30, 2022
    Inventors: Rima MCLEOD, Kamal EL BISSATI, Ying ZHOU, Jeff ALEXANDER, Steve REED, Peter BURKHARD, Mariane MELO, Darrel IRVINE, Ron WEISS, Yuan ZHANG
  • TOXOPLASMA GONDII VACCINES AND THEIR USE
    Publication number: 20200289629
    Abstract: Disclosed herein are polynucleotides encoding multi-epitope polypeptides and assemblies thereof, and their use for treating or limiting Toxoplasma gondii infection.
    Type: Application
    Filed: June 3, 2020
    Publication date: September 17, 2020
    Inventors: Rima MCLEOD, Kamal EL BISSATI, Ying ZHOU, Jeff ALEXANDER, Lo VANG, Steve REED, Sara M. PAULILLO, Senthil K. RAMAN, Peter BURKHARD, Mariane MELO, Darrel IRVINE, Ron WEISS, Yuan ZHANG, Alessandro SETTE, John SIDNEY, Brian D. LIVINGSTON, Hernan LORENZI
  • Compounds and Methods for Treating, Detecting, and Identifying Compounds to Treat Apicomplexan Parasitic Diseases
    Publication number: 20200283391
    Abstract: Disclosed herein; are novel compounds for treating apicomplexan parasite related disorders, methods for their use; cell line and non-human animal models of the dormant parasite phenotype and methods for their use in identifying new drugs to treat apicomplexan parasite related disorders, and biomarkers to identify disease due to the parasite and its response to treatment.
    Type: Application
    Filed: December 20, 2016
    Publication date: September 10, 2020
    Inventors: Rima McLeod, Martin McPhillie, Colin W.G. Fishwick, Hernan Alejandro Lorenzi, Kai Wang, Taek-Kyun Kim, Yong Zhou, Leroy E. Hood, Ying Zhou, Kamal El Bissati, James Gordon, Mark Hickman, QiGui Li, Craig Roberts
  • Methods and reagents for Toxoplasma infection diagnosis
    Publication number: 20200057057
    Abstract: Point-of-care (POC) testing for T. gondii infection can potentially address cost concerns and lead to better clinical outcomes through improved access to screening. This disclosure provides methods and compositions for whole blood POC testing to identify T. gondii infection with high sensitivity and specificity, obviating the need for venipuncture and sample processing infrastructure, making it an efficient, low-cost POC test.
    Type: Application
    Filed: August 16, 2019
    Publication date: February 20, 2020
    Inventors: Denis LIMONNE, Rima MCLEOD, Francois PEYRON, Kamal EL-BISSATI, Joe LYKINS
  • TOXOPLASMA GONDII VACCINES AND THEIR USE
    Publication number: 20190282679
    Abstract: Disclosed herein are polynucleotides encoding multi-epitope polypeptides and assemblies thereof, and their use for treating or limiting Toxoplasma gondii infection.
    Type: Application
    Filed: April 14, 2017
    Publication date: September 19, 2019
    Inventors: Rima MCLEOD, Kamal EL BISSATI, Ying ZHOU, Jeff ALEXANDER, Lo VANG, Steve REED, Sara M. PAULILLO, Senthil K. RAMAN, Peter BURKHARD, Mariane MELO, Darrel IRVINE, Ron WEISS, Yuan ZHANG, Alessandro SETTE, John SIDNEY, Brian D. LIVINGSTON, Hernan LORENZI
  • Vaccines against
    Patent number: 9408899
    Abstract: Vaccines are disclosed against parasites. The vaccines include peptides in an immunological composition. In particular, the parasite is Toxoplas gondii.
    Type: Grant
    Filed: November 3, 2011
    Date of Patent: August 9, 2016
    Assignees: The University of Chicago, Infectious Disease Research Institute, Paxvax, Inc.
    Inventors: Rima McLeod, Tze Guan Tan, Jeffery L. Alexander, Hua Cong, William H. Witola, Kamal El Bissati, Ernest J. Mui, Steven G. Reed
  • Conjugate constructs, delivery, and use for treatment of disease
    Patent number: 8575126
    Abstract: Pharmaceutical formulations of antisense peptide-conjugated phosphorodiamidate morpholino olgomers and methods of use for treatment of apicomplexan infections are disclosed. The invention is particularly directed to treatment of Toxoplasma gondii infections.
    Type: Grant
    Filed: June 27, 2012
    Date of Patent: November 5, 2013
    Inventors: Rima McLeod, Bo Shiun Lai, William Witola, Kamal El Bissati, Ernest Mui, Hong Moulton, Jonathan B Rothbard, Jon D Moulton
  • VACCINES AGAINST TOXOPLASMA GONDII
    Publication number: 20130273094
    Abstract: Vaccines are disclosed against parasites. The vaccines include peptides in an immunological composition. In particular, the parasite is Toxoplas gondii.
    Type: Application
    Filed: November 3, 2011
    Publication date: October 17, 2013
    Applicants: THE UNIVERSITY OF CHICAGO, PAXVAX, INC., INFECTIOUS DISEASE RESEARCH INSTITUTE
    Inventors: Rima McLeod, Tze Guan Tan, Jeffery L. Alexander, Hua Cong, William H. Witola, Kamal El Bissati, Ernest J. Mui, Steven G. Reed
  • Conjugate constructs, delivery, and use for treatment of disease
    Publication number: 20130053427
    Abstract: Pharmaceutical formulations of antisense peptide-conjugated phosphorodiamidate morpholino olgomers and methods of use for treatment of apicomplexan infections are disclosed. The invention is particularly directed to treatment of Toxoplasma gondii infections.
    Type: Application
    Filed: June 27, 2012
    Publication date: February 28, 2013
    Inventors: Rima McLeod, Bo Shiun Lai, William Witola, Kamal El Bissati, Ernest Mui, Hong Moulton, Jonathan B. Rothbard, Jon D. Moulton
  • Use of conditional plasmodium strains lacking nutrient transporters in malaria vaccination
    Patent number: 8128921
    Abstract: The present invention relates to a malaria vaccine for administration to a host comprising an attenuated malarial parasite with a gene which has been rendered non-functional, wherein the gene, when present in naturally occurring form, encodes a protein necessary for continued in vivo survival and proliferation of the parasite and for infection of host red blood cells. The invention further relates to a malaria vaccine in which a gene that encodes a nutrient transporter protein has been rendered non-functional.
    Type: Grant
    Filed: July 11, 2007
    Date of Patent: March 6, 2012
    Assignee: University of Connecticut
    Inventors: Choukri Ben Mamoun, Kamal El Bissati