Patents by Inventor Kamaraj Sriraghavan

Kamaraj Sriraghavan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SPIRO AND DISPIRO 1,2,4-TRIOXOLANE ANTIMALARIALS
    Publication number: 20080125441
    Abstract: A means and method for treating malaria, schistosomiasis, and cancer using a Spiro or dispiro 1,2,4-trioxolane is described. The preferred 1,2,4-trioxolanes include a spiroadamantane group on one side of the trioxolane group, and a spirocyclohexyl on the other side of the trioxolane group, whereby the spirocyclohexyl ring is preferably substituted at the 4-position. In comparison to artemisinin semisynthetic derivatives, the compounds of this invention are structurally simple, easy to synthesize, non-toxic, and potent against malarial parasites.
    Type: Application
    Filed: October 31, 2007
    Publication date: May 29, 2008
    Applicant: MEDICINES FOR MALARIA VENTURE MMV
    Inventors: JONATHAN L. VENNERSTROM, YUXIANG DONG, SUSAN A. CHARMAN, SERGIO WITTLIN, JACQUES CHOLLET, XIAOFANG WANG, KAMARAJ SRIRAGHAVAN, LIN ZHOU, HUGUES MATILE, WILLIAM N. CHARMAN
  • DISPIRO 1,2,4-TRIOXOLANE ANTIMALARIALS
    Publication number: 20080125411
    Abstract: A means and method for treating malaria, schistosomiasis, and cancer using a spiro or dispiro 1,2,4-trioxolane is described. The preferred 1,2,4-trioxolanes include a spiroadamantane group on one side of the trioxolane group, and a spirocyclohexyl on the other side of the trioxolane group. In comparison to artemisinin semisynthetic derivatives, the compounds of this invention are structurally simple, easy to synthesize, non-toxic, and potent against malarial parasites. The compounds of the invention unexpectedly provide a single-dose cure for malaria, as well as prophylactic activity against the same. The compounds are also active against schistosomiasis and cancer.
    Type: Application
    Filed: October 31, 2007
    Publication date: May 29, 2008
    Applicant: MEDICINES FOR MALARIA VENTURE MMV
    Inventors: JONATHAN L. VENNERSTROM, YUXIANG DONG, SUSAN A. CHARMAN, SERGIO WITTLIN, JACQUES CHOLLET, DARREN J. CREEK, XIAOFANG WANG, KAMARAJ SRIRAGHAVAN, LIN ZHOU, HUGUES MATILE, WILLIAM N. CHARMAN
  • Spiro and dispiro 1,2,4-trioxolane antimalarials
    Publication number: 20050256185
    Abstract: A means and method for treating malaria, schistosomiasis, and cancer using a spiro or dispiro 1,2,4-trioxolane is described. The preferred 1,2,4-trioxolanes include a spiroadamantane group on one side of the trioxolane group, and a spirocyclohexyl on the other side of the trioxolane group, whereby the spirocyclohexyl ring is preferably substituted at the 4-position. In comparison to artemisinin semisynthetic derivatives, the compounds of this invention are structurally simple, easy to synthesize, non-toxic, and potent against malarial parasites.
    Type: Application
    Filed: May 4, 2005
    Publication date: November 17, 2005
    Applicant: MEDICINES FOR MALARIA VENTURE MMV
    Inventors: Jonathan Vennerstrom, Yuxiang Dong, Jacques Chollet, Hugues Matile, Xiaofang Wang, Kamaraj Sriraghavan, William Charman