Patents by Inventor Kamehameha K. Wong, Jr.

Kamehameha K. Wong, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Replication capable rAAV vectors encoding inhibitory siRNA and methods of their use
    Patent number: 10370662
    Abstract: In some embodiments, an antiviral vector is provided. The antiviral vector includes a replication competent adeno-associated virus (AAV) and an inhibitory expression cassette that includes a nucleotide sequence that encodes an RNAi molecule that inhibits expression of a targeted helper virus (THV) gene. The THV gene may be part of an Adenovirus (Ad) genome, a Human Papillomavirus (HPV) genome, a Human Herpes Virus (HHV) genome, or a Vaccinia virus (VV) genome.
    Type: Grant
    Filed: October 9, 2017
    Date of Patent: August 6, 2019
    Assignee: CITY OF HOPE
    Inventors: Kamehameha K. Wong, Jr., Cam Mroske, Saswati Chatterjee
  • ADENO-ASSOCIATED VIRUS COMPOSITIONS FOR RESTORING HBB GENE FUNCTION AND METHODS OF USE THEREOF
    Publication number: 20190134118
    Abstract: Provided herein are adeno-associated virus (AAV) compositions for correcting a mutation in a beta globin gene (HBB) gene and methods of using the same to correct an HBB gene mutation in a cell. Also provided are packaging systems for making the adeno-associated virus compositions.
    Type: Application
    Filed: October 17, 2018
    Publication date: May 9, 2019
    Inventors: Saswati Chatterjee, Kamehameha K. Wong, Jr., Marwa BenHajSalah, Laura Jane Smith, Albert Barnes Seymour, Jason Boke Wright, James Anthony McSwiggen, Serena Nicole Dollive, Thia Baboval St. Martin, Jaime Michelle Prout
  • Recombinant adeno-associated vectors for targeted treatment
    Patent number: 9803218
    Abstract: Novel adeno-associated virus (AAV) vectors in nucleotide and amino acid forms and uses thereof are provided. The isolates show specific tropism for certain target tissues, such as blood stem cells, liver, heart and joint tissue, and may be used to transduce stem cells for introduction of genes of interest into the target tissues. Certain of the vectors are able to cross tightly controlled biological junctions, such as the blood-brain barrier, which open up additional novel uses and target organs for the vectors, providing for additional methods of gene therapy and drug delivery.
    Type: Grant
    Filed: October 28, 2016
    Date of Patent: October 31, 2017
    Assignee: CITY OF HOPE
    Inventors: Saswati Chatterjee, Laura Jane Smith, Kamehameha K. Wong, Jr.
  • Replication capable rAAV vectors encoding inhibitory siRNA and methods of their use
    Patent number: 9783805
    Abstract: In some embodiments, an antiviral vector is provided. The antiviral vector includes a replication competent adeno-associated virus (AAV) and an inhibitory expression cassette that includes a nucleotide sequence that encodes an RNAi molecule that inhibits expression of a targeted helper virus (THV) gene. The THV gene may be part of an Adenovirus (Ad) genome, a Human Papillomavirus (HPV) genome, a Human Herpes Virus (HHV) genome, or a Vaccinia virus (W) genome.
    Type: Grant
    Filed: February 28, 2014
    Date of Patent: October 10, 2017
    Assignee: CITY OF HOPE
    Inventors: Kamehameha K. Wong, Jr., Cam Mroske, Saswati Chatterjee
  • RECOMBINANT ADENO-ASSOCIATED VECTORS FOR TARGETED TREATMENT
    Publication number: 20170073703
    Abstract: Novel adeno-associated virus (AAV) vectors in nucleotide and amino acid forms and uses thereof are provided. The isolates show specific tropism for certain target tissues, such as blood stem cells, liver, heart and joint tissue, and may be used to transduce stem cells for introduction of genes of interest into the target tissues. Certain of the vectors are able to cross tightly controlled biological junctions, such as the blood-brain barrier, which open up additional novel uses and target organs for the vectors, providing for additional methods of gene therapy and drug delivery.
    Type: Application
    Filed: October 28, 2016
    Publication date: March 16, 2017
    Inventors: Saswati Chatterjee, Laura Jane Smith, Kamehameha K. Wong, JR.
  • REPLICATION CAPABLE rAAV VECTORS ENCODING INHIBITORY siRNA AND METHODS OF THEIR USE
    Publication number: 20140256799
    Abstract: In some embodiments, an antiviral vector is provided. The antiviral vector includes a replication competent adeno-associated virus (AAV) and an inhibitory expression cassette that includes a nucleotide sequence that encodes an RNAi molecule that inhibits expression of a targeted helper virus (THV) gene. The THV gene may be part of an Adenovirus (Ad) genome, a Human Papillomavirus (HPV) genome, a Human Herpes Virus (HHV) genome, or a Vaccinia virus (W) genome.
    Type: Application
    Filed: February 28, 2014
    Publication date: September 11, 2014
    Inventors: Kamehameha K. WONG, JR., Cam MROSKE, Saswati CHATTERJEE
  • Method of genetically modifying very primitive quiescent human hematopoietic stem cells
    Patent number: 6919209
    Abstract: This invention relates to a method for transducing extremely primitive hematopoietic stem cells with high efficiency, using an adeno-associated vector. This vector stably transforms highly primitive CD34+++CD38= cells which reside in a quiescent state and retain to a larger extent the ability to repopulate the hematopoietic system.
    Type: Grant
    Filed: December 3, 1999
    Date of Patent: July 19, 2005
    Assignee: City of Hope
    Inventors: Saswati Chatterjee, Kamehameha K. Wong, Jr., Christie Wong, Grace Fisher-Adams