Patents by Inventor Kamen Voivodov
Kamen Voivodov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7479631Abstract: The invention provides a probe and a method of making the probe that is removably insertable into a gas phase ion spectrometer, the probe comprising a substrate having a surface and a hydrogel material on the surface, the hydrogel material comprising binding functionalities for binding with an analyte detectable by the gas phase ion spectrometer. The invention also provides a probe and a method of making the probe that is removably insertable into a gas phase ion spectrometer, the probe comprising a substrate having a surface and a plurality of particles that are uniform in diameter on the surface, the particles comprising binding functionalities for binding with an analyte detectable by the gas phase ion spectrometer.Type: GrantFiled: March 2, 2007Date of Patent: January 20, 2009Assignee: Bio-Rad Laboratories, Inc.Inventors: William E. Rich, Pil-Je Um, Kamen Voivodov, Tai-Tung Yip, Jody Beecher
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Publication number: 20070158547Abstract: The invention provides a probe and a method of making the probe that is removably insertable into a gas phase ion spectrometer, the probe comprising a substrate having a surface and a hydrogel material on the surface, the hydrogel material comprising binding functionalities for binding with an analyte detectable by the gas phase ion spectrometer. The invention also provides a probe and a method of making the probe that is removably insertable into a gas phase ion spectrometer, the probe comprising a substrate having a surface and a plurality of particles that are uniform in diameter on the surface, the particles comprising binding functionalities for binding with an analyte detectable by the gas phase ion spectrometer.Type: ApplicationFiled: March 2, 2007Publication date: July 12, 2007Applicant: Bio-Rad Laboratories, Inc.Inventors: William Rich, Pil-Je Um, Kamen Voivodov, Tai-Tung Yip, Jody Beecher
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Patent number: 7205156Abstract: The invention provides a probe and a method of making the probe that is removably insertable into a gas phase ion spectrometer, the probe comprising a substrate having a surface and a hydrogel material on the surface, the hydrogel material comprising binding functionalities for binding with an analyte detectable by the gas phase ion spectrometer. The invention also provides a probe and a method of making the probe that is removably insertable into a gas phase ion spectrometer, the probe comprising a substrate having a surface and a plurality of particles that are uniform in diameter on the surface, the particles comprising binding functionalities for binding with an analyte detectable by the gas phase ion spectrometer.Type: GrantFiled: October 6, 2004Date of Patent: April 17, 2007Assignee: Bio-Rad Laboratories, Inc.Inventors: William E. Rich, Pil-Je Um, Kamen Voivodov, Tai-Tung Yip, Jody Beecher
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Publication number: 20060183863Abstract: Zwitterionic polymers bearing positive and negative charges are readily prepared from easily accessible precursors. The polymers show enhanced binding affinities for analytes under high salt conditions, compared to similar polymers bearing a charge of a single polarity. The polymers can also include an energy absorbing moiety for use in matrix assisted laser desorption/ionization mass spectrometry. The polymer can also include a photo-curable group, which can be used to form cross-links within the bulk polymer or between the polymer and a surface functionalized with a polymerizable moiety. The polymers are incorporated into devices of use for the analysis, capture, separation, or purification of an analyte. In an exemplary embodiment, the invention provides a substrate coated with a polymer of the invention, the substrate being adapted for use as a probe for a mass spectrometer.Type: ApplicationFiled: February 14, 2005Publication date: August 17, 2006Applicant: Ciphergen Biosystems, Inc.Inventors: Wenxi Huang, Sarah Ngola, Kamen Voivodov
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Publication number: 20060183242Abstract: Polymers bearing metal chelating groups are readily prepared from easily accessible precursors. The polymers are readily converted to the corresponding metal chelates. The polymers can also include an energy absorbing moiety for use in matrix assisted laser desorption/ionization mass spectrometry. The polymer can also include a photo-curable group, which can be used to form cross-links within the bulk polymer or between the polymer and a surface functionalized with a polymerizable moiety. The polymers are incorporated into devices of use for the analysis, capture, separation, or purification of an analyte. In an exemplary embodiment, the invention provides a substrate coated with a polymer of the invention, the substrate being adapted for use as a probe for a mass spectrometer.Type: ApplicationFiled: February 14, 2005Publication date: August 17, 2006Applicant: Ciphergen Biosystems, Inc.Inventors: Wenxi Huang, Aaron Chen, Sarah Ngola, Kamen Voivodov
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Patent number: 6897072Abstract: The invention provides a probe and a method of making the probe that is removably insertable into a gas phase ion spectrometer, the probe comprising a substrate having a surface and a hydrogel material on the surface, the hydrogel material comprising binding functionalities for binding with an analyte detectable by the gas phase ion spectrometer. The invention also provides a probe and a method of making the probe that is removably insertable into a gas phase ion spectrometer, the probe comprising a substrate having a surface and a plurality of particles that are uniform in diameter on the surface, the particles comprising binding functionalities for binding with an analyte detectable by the gas phase ion spectrometer.Type: GrantFiled: April 27, 2000Date of Patent: May 24, 2005Assignee: Ciphergen Biosystems, Inc.Inventors: William E. Rich, Pil-Je Um, Kamen Voivodov, Tai-Tung Yip, Jody Beecher
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Publication number: 20050090016Abstract: The invention provides a probe and a method of making the probe that is removably insertable into a gas phase ion spectrometer, the probe comprising a substrate having a surface and a hydrogel material on the surface, the hydrogel material comprising binding functionalities for binding with an analyte detectable by the gas phase ion spectrometer. The invention also provides a probe and a method of making the probe that is removably insertable into a gas phase ion spectrometer, the probe comprising a substrate having a surface and a plurality of particles that are uniform in diameter on the surface, the particles comprising binding functionalities for binding with an analyte detectable by the gas phase ion spectrometer.Type: ApplicationFiled: October 6, 2004Publication date: April 28, 2005Applicant: Ciphergen Biosystems, Inc.Inventors: William Rich, Pil-Je Um, Kamen Voivodov, Tai-Tung Yip, Jody Beecher
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Publication number: 20030106997Abstract: This invention provides a mass spectrometry probe including a substrate having a surface and a film that coats the surface. The film includes openings that define features for the presentation of an analyte. The film also has a lower surface tension that the surface tension of the substrate surface, and has a water contact angle between 120° and 180°.Type: ApplicationFiled: November 21, 2002Publication date: June 12, 2003Applicant: Ciphergen Biosystems, Inc.Inventors: Jody Beecher, Frank Scheufele, Kamen Voivodov, Scot Weinberger, William Landgraf
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Patent number: 6555813Abstract: This invention provides a mass spectrometry probe including a substrate having a surface and a film that coats the surface. The film includes openings that define features for the presentation of an analyte. The film also has a lower surface tension that the surface tension of the substrate surface, and has a water contact angle between 120° and 180°.Type: GrantFiled: April 27, 2000Date of Patent: April 29, 2003Assignee: Ciphergen Biosystems, Inc.Inventors: Jody Beecher, Frank Scheufele, Kamen Voivodov, Scot Weinberger, William Landgraf