Patents by Inventor Kamen Voivodov

Kamen Voivodov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7479631
    Abstract: The invention provides a probe and a method of making the probe that is removably insertable into a gas phase ion spectrometer, the probe comprising a substrate having a surface and a hydrogel material on the surface, the hydrogel material comprising binding functionalities for binding with an analyte detectable by the gas phase ion spectrometer. The invention also provides a probe and a method of making the probe that is removably insertable into a gas phase ion spectrometer, the probe comprising a substrate having a surface and a plurality of particles that are uniform in diameter on the surface, the particles comprising binding functionalities for binding with an analyte detectable by the gas phase ion spectrometer.
    Type: Grant
    Filed: March 2, 2007
    Date of Patent: January 20, 2009
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: William E. Rich, Pil-Je Um, Kamen Voivodov, Tai-Tung Yip, Jody Beecher
  • Publication number: 20070158547
    Abstract: The invention provides a probe and a method of making the probe that is removably insertable into a gas phase ion spectrometer, the probe comprising a substrate having a surface and a hydrogel material on the surface, the hydrogel material comprising binding functionalities for binding with an analyte detectable by the gas phase ion spectrometer. The invention also provides a probe and a method of making the probe that is removably insertable into a gas phase ion spectrometer, the probe comprising a substrate having a surface and a plurality of particles that are uniform in diameter on the surface, the particles comprising binding functionalities for binding with an analyte detectable by the gas phase ion spectrometer.
    Type: Application
    Filed: March 2, 2007
    Publication date: July 12, 2007
    Applicant: Bio-Rad Laboratories, Inc.
    Inventors: William Rich, Pil-Je Um, Kamen Voivodov, Tai-Tung Yip, Jody Beecher
  • Patent number: 7205156
    Abstract: The invention provides a probe and a method of making the probe that is removably insertable into a gas phase ion spectrometer, the probe comprising a substrate having a surface and a hydrogel material on the surface, the hydrogel material comprising binding functionalities for binding with an analyte detectable by the gas phase ion spectrometer. The invention also provides a probe and a method of making the probe that is removably insertable into a gas phase ion spectrometer, the probe comprising a substrate having a surface and a plurality of particles that are uniform in diameter on the surface, the particles comprising binding functionalities for binding with an analyte detectable by the gas phase ion spectrometer.
    Type: Grant
    Filed: October 6, 2004
    Date of Patent: April 17, 2007
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: William E. Rich, Pil-Je Um, Kamen Voivodov, Tai-Tung Yip, Jody Beecher
  • Publication number: 20060183863
    Abstract: Zwitterionic polymers bearing positive and negative charges are readily prepared from easily accessible precursors. The polymers show enhanced binding affinities for analytes under high salt conditions, compared to similar polymers bearing a charge of a single polarity. The polymers can also include an energy absorbing moiety for use in matrix assisted laser desorption/ionization mass spectrometry. The polymer can also include a photo-curable group, which can be used to form cross-links within the bulk polymer or between the polymer and a surface functionalized with a polymerizable moiety. The polymers are incorporated into devices of use for the analysis, capture, separation, or purification of an analyte. In an exemplary embodiment, the invention provides a substrate coated with a polymer of the invention, the substrate being adapted for use as a probe for a mass spectrometer.
    Type: Application
    Filed: February 14, 2005
    Publication date: August 17, 2006
    Applicant: Ciphergen Biosystems, Inc.
    Inventors: Wenxi Huang, Sarah Ngola, Kamen Voivodov
  • Publication number: 20060183242
    Abstract: Polymers bearing metal chelating groups are readily prepared from easily accessible precursors. The polymers are readily converted to the corresponding metal chelates. The polymers can also include an energy absorbing moiety for use in matrix assisted laser desorption/ionization mass spectrometry. The polymer can also include a photo-curable group, which can be used to form cross-links within the bulk polymer or between the polymer and a surface functionalized with a polymerizable moiety. The polymers are incorporated into devices of use for the analysis, capture, separation, or purification of an analyte. In an exemplary embodiment, the invention provides a substrate coated with a polymer of the invention, the substrate being adapted for use as a probe for a mass spectrometer.
    Type: Application
    Filed: February 14, 2005
    Publication date: August 17, 2006
    Applicant: Ciphergen Biosystems, Inc.
    Inventors: Wenxi Huang, Aaron Chen, Sarah Ngola, Kamen Voivodov
  • Patent number: 6897072
    Abstract: The invention provides a probe and a method of making the probe that is removably insertable into a gas phase ion spectrometer, the probe comprising a substrate having a surface and a hydrogel material on the surface, the hydrogel material comprising binding functionalities for binding with an analyte detectable by the gas phase ion spectrometer. The invention also provides a probe and a method of making the probe that is removably insertable into a gas phase ion spectrometer, the probe comprising a substrate having a surface and a plurality of particles that are uniform in diameter on the surface, the particles comprising binding functionalities for binding with an analyte detectable by the gas phase ion spectrometer.
    Type: Grant
    Filed: April 27, 2000
    Date of Patent: May 24, 2005
    Assignee: Ciphergen Biosystems, Inc.
    Inventors: William E. Rich, Pil-Je Um, Kamen Voivodov, Tai-Tung Yip, Jody Beecher
  • Publication number: 20050090016
    Abstract: The invention provides a probe and a method of making the probe that is removably insertable into a gas phase ion spectrometer, the probe comprising a substrate having a surface and a hydrogel material on the surface, the hydrogel material comprising binding functionalities for binding with an analyte detectable by the gas phase ion spectrometer. The invention also provides a probe and a method of making the probe that is removably insertable into a gas phase ion spectrometer, the probe comprising a substrate having a surface and a plurality of particles that are uniform in diameter on the surface, the particles comprising binding functionalities for binding with an analyte detectable by the gas phase ion spectrometer.
    Type: Application
    Filed: October 6, 2004
    Publication date: April 28, 2005
    Applicant: Ciphergen Biosystems, Inc.
    Inventors: William Rich, Pil-Je Um, Kamen Voivodov, Tai-Tung Yip, Jody Beecher
  • Publication number: 20030106997
    Abstract: This invention provides a mass spectrometry probe including a substrate having a surface and a film that coats the surface. The film includes openings that define features for the presentation of an analyte. The film also has a lower surface tension that the surface tension of the substrate surface, and has a water contact angle between 120° and 180°.
    Type: Application
    Filed: November 21, 2002
    Publication date: June 12, 2003
    Applicant: Ciphergen Biosystems, Inc.
    Inventors: Jody Beecher, Frank Scheufele, Kamen Voivodov, Scot Weinberger, William Landgraf
  • Patent number: 6555813
    Abstract: This invention provides a mass spectrometry probe including a substrate having a surface and a film that coats the surface. The film includes openings that define features for the presentation of an analyte. The film also has a lower surface tension that the surface tension of the substrate surface, and has a water contact angle between 120° and 180°.
    Type: Grant
    Filed: April 27, 2000
    Date of Patent: April 29, 2003
    Assignee: Ciphergen Biosystems, Inc.
    Inventors: Jody Beecher, Frank Scheufele, Kamen Voivodov, Scot Weinberger, William Landgraf