Abstract: A three-dimensional printed swab may include a shaft defining a longitudinal axis of the swab, and a tip portion integrally formed with the shaft. The tip portion may include a body extending outward from the shaft and positioned coaxially with the longitudinal axis, and a plurality of protrusions each extending outward from the body and transverse to the longitudinal axis. Alternatively, the tip portion may include a body extending outward from the shaft and positioned coaxially with the longitudinal axis, and a plurality of recesses each defined in the body and extending inward toward the longitudinal axis. As another alternative, the tip portion may include a body extending outward from the shaft and positioned coaxially with the longitudinal axis, and a series of annular ribs each extending outward from the body and positioned coaxially with the longitudinal axis.

Abstract: A three-dimensional printed swab may include a shaft defining a longitudinal axis of the swab, and a tip portion integrally formed with the shaft. The tip portion may include a plurality of protrusions each extending outward from the shaft and transverse to the longitudinal axis. A method for fabricating a three-dimensional printed swab may include receiving a digital three-dimensional model corresponding to the swab, and integrally forming, via three-dimensional printing and based at least in part on the digital three-dimensional model, a shaft and a tip portion of the swab. The shaft may define a longitudinal axis of the swab. The tip portion may include a plurality of protrusions each extending outward from the shaft and transverse to the longitudinal axis.

Abstract: This invention relates to compounds that are analogues of coformycin, pharmaceutical compositions containing the compounds, and methods of using the compounds for treating protozoan parasite infections, especially malaria.

Abstract: The present invention relates to an attenuated Plasmodium parasite having a genome comprising a non-reversible knockout of the PyPNP gene, a vaccine derived therefrom, and related methods and uses.

Abstract: This invention relates to compounds that are analogues of coformycin, pharmaceutical compositions containing the compounds, and methods of using the compounds for treating protozoan parasite infections, especially malaria.

Abstract: A method of transient transfection of obligate intracellular parasites is described. This method is exploited to develop a system for stable transformation utilizing selectable genes. For example, introduction of the chloramphenicol acetyl transferase (CAT) gene fused to Toxoplasma flanking sequences followed by chloramphenicol selection results in parasites stably expressing CAT. DNA hybridization analysis indicated that the CAT gene had inserted via homologous recombination.

Abstract: A method of transient transfection of obligate intracellular parasites is described. This method is exploited to develop a system for stable transformation utilizing selectable genes. For example, introduction of the chloramphenicol acetyl transferase (CAT) gene fused to Toxoplasma flanking sequences followed by chloramphenicol selection results in parasites stably expressing CAT. DNA hybridization analysis indicated that the CAT gene had inserted via homologous recombination.