Patents by Inventor Kan K. Eng

Kan K. Eng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparation of integrin receptor antagonist intermediates
    Publication number: 20040030134
    Abstract: A novel process is provided for the preparation of chiral intermediates useful in the asymmetric syntheses of &agr;v&bgr;3 integrin receptor antagonists. Also provided are the enantiomerically enriched intermediates that are obtained from the process.
    Type: Application
    Filed: September 11, 2003
    Publication date: February 12, 2004
    Inventors: James Christopher McWilliams, Elizabeth Buck, Kan K. Eng, Guy R. Humphrey, Peter E. Maligres, Jess W. Sager, Marjorie See Waters
  • Process for making phenyl heterocycles useful as COX-2 inhibitors
    Patent number: 6080876
    Abstract: The invention encompasses a process for making compounds of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases.
    Type: Grant
    Filed: September 17, 1998
    Date of Patent: June 27, 2000
    Assignee: Merck & Co., Inc.
    Inventors: Ilias Dorziotis, Ioannis Houpis, Kan K. Eng
  • Process for making an epoxide
    Patent number: 5728840
    Abstract: A process for synthesizing the epoxide of the formula ##STR1## consists of, at a minimum, formation of a halohydrin from the allyl acetonide reactat, followed by base-induced cyclization, the epoxide product I being useful as an intermediate for the synthesis of inhibitors of renin or HIV protease or other proteases.
    Type: Grant
    Filed: August 8, 1995
    Date of Patent: March 17, 1998
    Assignee: Merck & Co., Inc.
    Inventors: David Askin, Kan K. Eng, Peter E. Maligres, Paul J. Reider, Kai Rossen, Ralph P. Volante, Veena Upadhyay, Steven A. Weissman
  • Process to make HIV protease inhibitor from (2S)-4-picolyl-2-piperazine-t-butylcarboxamide
    Patent number: 5618937
    Abstract: A process for making a clinically efficacious HIV protease inhibitor eliminates one step in its synthesis, by an alternative convergent synthesis using 2(S)-4-picolyl-2-piperazine-t-butylcarboxamide as an intermediate.
    Type: Grant
    Filed: March 15, 1995
    Date of Patent: April 8, 1997
    Assignee: Merck & Co., Inc.
    Inventors: David Askin, Kan K. Eng, Paul Reider, Ralph P. Volante
  • Process for making HIV protease inhibitors
    Patent number: 5496948
    Abstract: Intermediates of structural formula ##STR1## can be made by reacting glycidol or an activated derivative thereof with an amide. The process and intermediates are useful for synthesizing HIV protease inhibitor compounds.
    Type: Grant
    Filed: June 21, 1995
    Date of Patent: March 5, 1996
    Assignee: Merck & Co., Inc.
    Inventors: David Askin, Kan K. Eng, Ralph P. Volante
  • Process for making HIV protease inhibitors
    Patent number: 5491238
    Abstract: Intermediates of structural formula ##STR1## can be made by reacting glycidol or an activated derivative thereof with an amide. The process and intermediates are useful for synthesizing HIV protease inhibitor compounds.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: February 13, 1996
    Assignee: Merck & Co., Inc.
    Inventors: David Askin, Ralph P. Volante, Kan K. Eng
  • Process for making HIV protease inhibitors
    Patent number: 5463067
    Abstract: Intermediates of structural formula ##STR1## can be made by reacting glycidol or an activated derivative thereof with an amide. The process and intermediates are useful for synthesizing HIV protease inhibitor compounds.
    Type: Grant
    Filed: January 26, 1994
    Date of Patent: October 31, 1995
    Assignee: Merck & Co., Inc.
    Inventors: David Askin, Kan K. Eng, Ralph P. Volante