Patents by Inventor Kan Kikuchi

Kan Kikuchi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20120251498
    Abstract: Application of a virus with poloxamer alone onto atria results in diffuse epicardial gene transfer with negligible penetration into the myocardium. Progressive increases in protease concentration, however, allow transmural gene transfer. After protease exposure, echocardiographic left atrial diameter does not change. Left atrial ejection fraction decreases on post-operative day 3, but returns to baseline by day 7. At appropriate protease concentrations, tissue tensile strength is unaffected by the procedure. Transmural atrial gene transfer can be effected using this direct “painting” method.
    Type: Application
    Filed: May 7, 2012
    Publication date: October 4, 2012
    Applicant: The Johns Hopkins University
    Inventors: J. Kevin Donahue, Amy D. McDonald, Kan Kikuchi
  • Publication number: 20080261909
    Abstract: Application of a virus with poloxamer alone onto atria results in diffuse epicardial gene transfer with negligible penetration into the myocardium. Progressive increases in protease concentration, however, allow transmural gene transfer. After protease exposure, echocardiographic left atrial diameter does not change. Left atrial ejection fraction decreases on post-operative day 3, but returns to baseline by day 7. At appropriate protease concentrations, tissue tensile strength is unaffected by the procedure. Transmural atrial gene transfer can be effected using this direct “painting” method.
    Type: Application
    Filed: February 11, 2008
    Publication date: October 23, 2008
    Applicant: The John Hopkins University
    Inventors: J. Kevin Donahue, Amy D. McDonald, Kan Kikuchi
  • Publication number: 20050014714
    Abstract: Application of a virus with poloxamer alone onto atria results in diffuse epicardial gene transfer with negligible penetration into the myocardium. Progressive increases in protease concentration, however, allow transmural gene transfer. After protease exposure, echocardiographic left atrial diameter does not change. Left atrial ejection fraction decreases on post-operative day 3, but returns to baseline by day 7. At appropriate protease concentrations, tissue tensile strength is unaffected by the procedure. Transmural atrial gene transfer can be effected using this direct “painting” method.
    Type: Application
    Filed: June 3, 2004
    Publication date: January 20, 2005
    Applicant: The Johns Hopkins University
    Inventors: J. Kevin Donahue, Amy McDonald, Kan Kikuchi