Abstract: The present application relates to a stepwise-clamping type valve prosthesis including a frame body and a clamping member. The frame body has a channel allowing blood to flow therethrough. The clamping member includes a first clamping member and a second clamping member. One end of the first clamping member is connected to the frame body, and the other end of the first clamping member is a free end. The second clamping member is connected to the first clamping member. The clamping member has three states in sequence from being restricted to being fully released. In the first state, the first clamping member and the second clamping member are both restricted and restricted. In the second state, the second clamping member is restricted, and the first clamping member extends in a radial direction of the frame body and is capable of reaching a position between a valve leaflet and a heart wall.

Abstract: The present application provides anti-TIGIT constructs that bind to TIGIT (e.g., anti-TIGIT antibodies), nucleic acid molecules encoding an amino acid sequence of the anti-TIGIT, vectors comprising the nucleic acid molecules, host cells containing the vectors, methods of preparing the anti-TIGIT construct, pharmaceutical compositions containing the anti-TIGIT construct, and methods of using the anti-TIGIT construct or compositions.

Abstract: The present application provides anti-PLA2G2D constructs that bind to PLA2G2D (e.g., anti-PLA2G2D antibodies), nucleic acid molecules encoding an amino acid sequence of the anti-PLA2G2D, vectors comprising the nucleic acid molecules, host cells containing the vectors, methods of preparing the anti-PLA2G2D construct, pharmaceutical compositions containing the anti-PLA2G2D construct, and methods of using the anti-PLA2G2D construct or compositions.

Abstract: The present application relates to a transcatheter prosthetic valve replacement system including a delivery catheter, a frame, a prosthetic valve, and one or more clamping devices. The prosthetic valve is fixed in the frame. The clamping device is connected to a periphery of the frame. The frame and the clamping device can be preloaded in the delivery catheter. The clamping device includes a clamping member, a collar, and a control member. One end of the clamping member is a fixation end which is fixedly connected to the frame, and the other end of the clamping member is a deployable resilient segment which can be compressed and released. The collar is slidably sleeved on the clamping member. One end of the control member is connected to the collar, and the other end of the control member is manipulated outside the body. From being compressed to being fully released, the clamping member in sequence has two configurations.

Abstract: An integrally detachable valve clamp and delivery system thereof, includes a control handle, a delivery catheter connected to the control handle, and a valve clamp connected to the delivery catheter, wherein the valve clamp is equipped with an inner catheter and an outer catheter, both of which are equipped with detachable connection mechanisms; the delivery catheter comprises a first delivery catheter, a central control unit, and a second delivery catheter; the distal parts of both the first delivery catheter and the second delivery catheter are equipped with releasable connection mechanisms that match the detachable connection mechanisms.

Abstract: Valve clip having locking mechanism includes first clamping arm, second clamping arm, linking member, push-pull device and locking device. The locking device fitted with the linking member and includes locking head and self-locking rod. The linking member hinged to each of the first clamping arm and the second clamping arm which include a long arm whose end is hinged to the push-pull device and a short arm whose end is provided with a locking portion. When the push-pull device operated to enlarge opening angle between the long arms of the first clamping arm and the second clamping arm in an open state, the locking portions of the first clamping arm and the second clamping arm are in a staggered fit state; and when to narrow the opening angle in a closed state, the locking device moved to cause the locking head to be fitted and locked to the locking portions.

Abstract: The present application provides anti-B7-H4 constructs that bind to B7-H4 (e.g., anti-B7-H4 antibodies), nucleic acid molecules encoding an amino acid sequence of the anti-B7-H4, vectors comprising the nucleic acid molecules, host cells containing the vectors, methods of preparing the anti-B7-H4 construct, pharmaceutical compositions containing the anti-B7-H4 construct, and methods of using the anti-B7-H4 construct or compositions.

Abstract: The present application provides methods of treating a disease (such as cancer or infectious disease) that involves an antagonist that targets PLA2G2D signaling pathway (such as an antagonist that targets PLA2G2D. The present application also provides non-naturally occurring PLA2G2D polypeptides.

Abstract: The present application relates to a transcatheter prosthetic valve replacement system including a delivery catheter, a frame, a prosthetic valve, and one or more clamping devices. The prosthetic valve is fixed in the frame. The clamping device is connected to a periphery of the frame. The frame and the clamping device can be preloaded in the delivery catheter. The clamping device includes a clamping member, a collar, and a control member. One end of the clamping member is a fixation end which is fixedly connected to the frame, and the other end of the clamping member is a deployable resilient segment which can be compressed and released. The collar is slidably sleeved on the clamping member. One end of the control member is connected to the collar, and the other end of the control member is manipulated outside the body. From being compressed to being fully released, the clamping member in sequence has two configurations.

Abstract: The present application relates to a stepwise-clamping type valve prosthesis including a frame body and a clamping member. The frame body has a channel allowing blood to flow therethrough. The clamping member includes a first clamping member and a second clamping member. One end of the first clamping member is connected to the frame body, and the other end of the first clamping member is a free end. The second clamping member is connected to the first clamping member. The clamping member has three states in sequence from being restricted to being fully released. In the first state, the first clamping member and the second clamping member are both restricted and restricted. In the second state, the second clamping member is restricted, and the first clamping member extends in a radial direction of the frame body and is capable of reaching a position between a valve leaflet and a heart wall.

Abstract: A focusing and leveling apparatus, including: an illumination light source (201) for emanating a light beam; an illumination lens group (202), a projecting unit, an object (209) being measured, a detecting unit, a refractive unit, a relay lens group and a photoelectric detector (220), disposed sequentially in this order in a transmission path of the light beam. The projecting unit includes projection slits (203) defining a plurality of non-linearly arranged marks, such that after passing sequentially through the illumination lens group (202), the projecting unit, the object (209) being measured and the detecting unit, the light beam emanated by the illumination light source (201) becomes a plurality of non-linearly arranged sub-beams corresponding to the plurality of marks. The refractive unit is so configured that after passing through the refractive unit, the plurality of sub-beams form a plurality of linearly arranged light spots.

Abstract: A focusing and leveling apparatus, including: an illumination light source (201) for emanating a light beam; an illumination lens group (202), a projecting unit, an object (209) being measured, a detecting unit, a refractive unit, a relay lens group and a photoelectric detector (220), disposed sequentially in this order in a transmission path of the light beam. The projecting unit includes projection slits (203) defining a plurality of non-linearly arranged marks, such that after passing sequentially through the illumination lens group (202), the projecting unit, the object (209) being measured and the detecting unit, the light beam emanated by the illumination light source (201) becomes a plurality of non-linearly arranged sub-beams corresponding to the plurality of marks. The refractive unit is so configured that after passing through the refractive unit, the plurality of sub-beams form a plurality of linearly arranged light spots.

Abstract: A wireless communication device and the method thereof are disclosed. The wireless communication device in accordance with the present invention includes an integrated protocol layer supporting a first communication protocol and a second communication protocol; a single transceiver operative to transmit and receive signals of said first and said second communication protocols.

Abstract: A multi-gateway system is disclosed. The multi-gate system may include an access point associated with a zone, the access point providing a network coverage within the zone; a wireless client adapted to communicate with the access point when the wireless client is in the zone; and a virtual central processing device associated with a virtual media access control (MAC) address, wherein the virtual central processing device communicates with the access point to redirect a data packet between the wireless client and a destination.

Abstract: A wireless communication device and the method thereof are disclosed. The wireless communication device in accordance with the present invention includes an integrated protocol layer supporting a first communication protocol and a second communication protocol; a single transceiver operative to transmit and receive signals of said first and said second communication protocols.

Abstract: A method and apparatus for canceling a near-end echo of a far-end signal for each channel of a voice over packet multi-channel communications gateway. The invention applies “off-the-shelf” coding mechanisms as well as novel coding schemes to provide fixed compression rate and with options to maintain perfect speech integrity on certain processing components, such as network echo canceller, acoustic echo canceller, Voice Activity Detector, Comfort Noise Generation, etc. The off-the-shelf compression algorithm includes LPC-10, G.723.1, G.729A. The alternatives are Wavelet transform, DPCM, and ADPCM, etc.

Abstract: The present invention provides a register-indirect addressing mode using modulo arithmetic to transpose addresses for digital processing systems. The preferred systems and methods permit direct access of column data, which improves matrix computation significantly. The overhead of transpose mode is minimal because it can be implemented, if desired, by sharing hardware and/or software used in circular buffers. Transpose addressing mode also reduces program size and processor power consumed by reducing the sequence of instruction cycles.

Abstract: A method and apparatus for canceling a near-end echo of a far-end signal for each channel of a voice over packet multi-channel communications gateway. The invention applies “off-the-shelf” coding mechanisms as well as novel coding schemes to provide fixed compression rate and with options to maintain perfect speech integrity on certain processing components, such as network echo canceller, acoustic echo canceller, Voice Activity Detector, Comfort Noise Generation, etc. The off-the-shelf compression algorithm includes LPC-10, G.723.1, G.729A. The alternatives are Wavelet transform, DPCM, and ADPCM, etc.

Abstract: A flip-flop (14) is disclosed that includes an input circuit (50), a sense amplifier (52) and an output circuit (56). The input circuit (50) is operable to receive a data input signal and to generate complementary data signals. The sense amplifier (52) is coupled to the input circuit (50). The sense amplifier (52) is operable to receive the data signals from the input circuit (50) and to generate complementary amplified signals based on the data signals. The output circuit (56) is coupled to the sense amplifier (52). The output circuit (56) is operable to receive the amplified signals from the sense amplifier (52) and to generate complementary output signals based on the amplified signals.

Abstract: A flip-flop (14) is disclosed that includes an input circuit (50), a sense amplifier (52) and an output circuit (56). The input circuit (50) is operable to receive a data input signal and to generate complementary data signals. The sense amplifier (52) is coupled to the input circuit (50). The sense amplifier (52) is operable to receive the data signals from the input circuit (50) and to generate complementary amplified signals based on the data signals. The output circuit (56) is coupled to the sense amplifier (52). The output circuit (56) is operable to receive the amplified signals from the sense amplifier (52) and to generate complementary output signals based on the amplified signals.