Patents by Inventor Kan S. Lee

Kan S. Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Stannylated 3-quinuclidinyl benzilates and methods of preparing radiohalogenated derivatives
    Patent number: 5569447
    Abstract: The present invention provides stannylated 3-quinuclidinyl benzilate compounds and a method of synthesizing *AQNB by iodinating such stannylated 3-quinuclidinyl benzilate compounds. The iodination of these stannylated 3-quinuclidinyl benzilates proceeds in as little as five minutes; thus, the stannylated 3-quinuclidinyl benzilates may be converted to *AQNB in situ for immediate use. Using this method, radiolabelling yields as high as 80% have been observed. The present invention also is directed towards a method of synthesis of the stannylated 3-quinuclidinyl benzilate compounds. The method comprises providing a 4'-halo-3-quinuclidinyl benzilate and reacting the 4'-halo-3-quinuclidinyl benzilate with a compound having the formula (SnR.sub.3).sub.2, wherein R is an alkyl.
    Type: Grant
    Filed: April 19, 1994
    Date of Patent: October 29, 1996
    Assignee: The United States of America represented by the Secretary Department of Health and Human Services
    Inventors: Kan S. Lee, Xiao-Shu He, Daniel R. Weinberger