Abstract: The present disclosure provides macrocyclic compounds inspired by the immunophilin ligand family of natural products FK506 and rapamycin. The generation of a Rapafucin library of macrocyles that contain FK506 and rapamycin binding domains should have great potential as new leads for developing drugs to be used for treating diseases.

Abstract: One embodiment of the present disclosure provides a resin layer 10 used for an image displaying device, wherein a shear storage elastic modulus G? of the resin layer 10, at 25° C. and frequency range of 500 Hz or more and 1000 Hz or less, is 30 MPa or more and 200 MPa or less, and a glass transition temperature of the resin layer 10 is 50° C. or more.

Abstract: The present disclosure provides macrocyclic compounds inspired by the immunophilin ligand family of natural products FK506 and rapamycin. The generation of a Rapafucin library of macrocyles that contain FK506 and rapamycin binding domains should have great potential as new leads for developing drugs to be used for treating diseases.

Abstract: The present disclosure provides a front panel for a display device comprising a substrate layer, an A layer, an impact absorbing layer, and a B layer, in this order, wherein a shear storage elastic modulus of the A layer and the B layer, at frequency of 950 Hz and temperature of 23° C., is 20 MPa or less, and in the impact absorbing layer, a tensile storage elastic modulus at frequency of 950 Hz and temperature of 23° C. is 200 MPa or more and 5000 MPa or less, and a glass transition temperature is 50° C. or more.

Abstract: The present disclosure provides macrocyclic compounds inspired by the immunophilin ligand family of natural products FK506 and rapamycin. The generation of a Rapafucin library of macrocyles that contain FK506 and rapamycin binding domains should have great potential as new leads for developing drugs to be used for treating diseases.

Abstract: The present invention aims to provide an image display device including an optical film having a thickness suitable for practical use without including any special inorganic material, wherein the image display device has high color rendering properties and is capable of minimizing the occurrence of blackout and interference colors (rainbow unevenness) even when the image display device includes light sources that emit light having a narrow emission spectrum. The present invention provides an image display device including an optical film having an in-plane birefringence and a polarizer in this order, wherein the optical film and the polarizer are disposed to form an angle of about 45° between a slow axis of the optical film and an absorption axis of the polarizer, the optical film has a retardation of 3000 nm or more, and light incident on the optical film provides at least 50% coverage of ITU-R BT.2020.

Abstract: Provided is an optical layered body which is extremely high in the stability of the antistatic performance, and has a stable surface resistance even after a durability test. The optical layered body includes an antistatic layer on one face of a light-transmitting substrate, wherein the antistatic layer is formed using a composition for an antistatic layer containing conductive fine particles, a resin component, and a solvent, and the resin component has no reactive functional groups in a molecule, and is soluble in the solvent and compatible with the conductive fine particles.

Abstract: The present disclosure provides macrocyclic compounds inspired by the immunophilin ligand family of natural products FK506 and rapamycin. The generation of a Rapafucin library of macrocyles that contain FK506 and rapamycin binding domains should have great potential as new leads for developing drugs to be used for treating diseases.

Abstract: The present disclosure provides macrocyclic compounds inspired by the immunophilin ligand family of natural products FK506 and rapamycin. The generation of a Rapafucin library of macrocyles that contain FK506 and rapamycin binding domains should have great potential as new leads for developing drugs to be used for treating diseases.

Abstract: The present invention provides an optical layered body having excellent blue light blocking properties without affecting the color tone of displayed images. Provided is an optical layered body having a structure including: a substrate; and one or two or more functional layers on at least one surface of the substrate, the optical layered body having a spectral transmittance at a wavelength of 380 nm of lower than 1%, a spectral transmittance at a wavelength of 410 nm of lower than 10%, and a spectral transmittance at a wavelength of 440 nm of 70% or higher.

Abstract: The present invention aims to provide an image display device including an optical film having a thickness suitable for practical use without including any special inorganic material, wherein the image display device has high color rendering properties and is capable of minimizing the occurrence of blackout and interference colors (rainbow unevenness) even when the image display device includes light sources that emit light having a narrow emission spectrum. The present invention provides an image display device including an optical film having an in-plane birefringence and a polarizer in this order, wherein the optical film and the polarizer are disposed to form an angle of about 45° between a slow axis of the optical film and an absorption axis of the polarizer, the optical film has a retardation of 3000 nm or more, and light incident on the optical film provides at least 50% coverage of ITU-R BT.2020.

Abstract: The present disclosure provides macrocyclic compounds inspired by the immunophilin ligand family of natural products FK506 and rapamycin. The generation of a Rapafucin library of macrocyles that contain FK506 and rapamycin binding domains should have great potential as new leads for developing drugs to be used for treating diseases.

Abstract: The present invention provides an optical layered body having excellent blue light blocking properties without affecting the color tone of displayed images. Provided is an optical layered body having a structure including: a substrate; and one or two or more functional layers on at least one surface of the substrate, the optical layered body having a spectral transmittance at a wavelength of 380 nm of lower than 1%, a spectral transmittance at a wavelength of 410 nm of lower than 10%, and a spectral transmittance at a wavelength of 440 nm of 70% or higher.

Abstract: Provided are [1] an optical laminate comprising a substrate film, a transparent conductive layer and a surface protection layer in this order, wherein an average value of a surface resistivity measured according to JIS K6911 is in the range of 1.0×107 ?/? or more and 1.0×1010 ?/? or less, and a standard deviation ? of the surface resistivity is 5.0×108 ?/? or less, [2] an optical laminate comprising a substrate film, a transparent conductive layer and a surface protection layer in this order, wherein the substrate film is a cycloolefin polymer film, a ratio of a thickness of the substrate film to a thickness of the entire optical laminate is 80% or more and 95% or less, and a rate of elongation of the optical laminate at a temperature of 150° C., as measured using a dynamic viscoelasticity measuring apparatus under conditions of a frequency of 10 Hz, a tensile load of 50 N and a rate of temperature increase of 2° C./min, is 5.

Abstract: A concise method of producing nylon 11, 12, or 13 precursors from oleic acid or an ester of oleic acid is described. The method involves cross-metathesis reactions as the key C—C bond formation step. Subsequent steps are provided to convert the metathesis product to the corresponding nylon precursors. Also provided are the products of the method.

Abstract: Provided herein is a method of producing C11, C12, and C13 nylon precursors from oleic acid or esters of oleic acid, the method involving amide formation, ring-closing metathesis, and hydrogenation. Further provided are the products of the method described. Provided herein is a method for producing a lactam, the method comprising the steps of converting oleic acid or an ester of oleic acid into an amide having a general formula of H3C—(CH2)rCH?CH—(CH2)rCONR—(CH2)n-CH?CH2, wherein n is 1, 2, or 3, and R is either hydrogen or benzyl; subjecting the amide to a ring-closing metathesis reaction to produce an intermediate having a general formula of —(CH2)rCONR—(CH2) n-CH?CH2-, wherein n is 1, 2, or 3, R is either hydrogen or benzyl, and both ends are connected to each other; and hydrogenating the intermediate to produce a saturated lactam. In certain embodiments, the saturated lactam has a formula of —NH—(CH2) 10-CO—.

Abstract: A concise method of producing nylon 11, 12, or 13 precursors from oleic acid or an ester of oleic acid is described. The method involves cross-metathesis reactions as the key C—C bond formation step. Subsequent steps are provided to convert the metathesis product to the corresponding nylon precursors. Also provided are the products of the method.

Abstract: Provided herein is a method of producing C11, C12, and C13 nylon precursors from oleic acid or esters of oleic acid, the method involving amide formation, ring-closing metathesis, and hydrogenation. Further provided are the products of the method described. Provided herein is a method for producing a lactam, the method comprising the steps of converting oleic acid or an ester of oleic acid into an amide having a general formula of H3C—(CH2)rCH?CH—(CH2)rCONR—(CH2)n—CH?CH2, wherein n is 1, 2, or 3, and R is either hydrogen or benzyl; subjecting the amide to a ring-closing metathesis reaction to produce an intermediate having a general formula of —(CH2)rCONR—(CH2) n—CH?CH2—, wherein n is 1, 2, or 3, R is either hydrogen or benzyl, and both ends are connected to each other; and hydrogenating the intermediate to produce a saturated lactam. In certain embodiments, the saturated lactam has a formula of —NH—(CH2) 10—CO—.

Abstract: A process is provided for preparing 4-(8-(2-chlorophenoxy)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)bicyclo[2.2.1]heptan-1-ol and novel intermediates used in the process. The compound is a 11-beta hydroxysteroid dehydrogenase type I inhibitor which exhibits activity in the treatment of various metabolic diseases.

Abstract: Provided herein are methods for fatty acid alkanolamide (FAAA) synthesis and isolation from lipid-containing algal biomass, and the products of such methods.