Patents by Inventor Kanchana Ravichandran

Kanchana Ravichandran has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RNA POLYMERASE VARIANTS
    Publication number: 20240102066
    Abstract: The present disclosure provides, in some aspects, variant RNA polymerases, the use of which increases transcription efficiency while reducing the number of double-stranded RNA contaminates and run-on transcripts produced during an in vitro transcription reaction.
    Type: Application
    Filed: August 11, 2023
    Publication date: March 28, 2024
    Applicant: ModernaTX, Inc.
    Inventors: Amy E. Rabideau, Athanasios Dousis, Kanchana Ravichandran, Elissa Hobert
  • Polynucleotides encoding phenylalanine hydroxylase for the treatment of phenylketonuria
    Patent number: 11939601
    Abstract: This disclosure relates to mRNA therapy for the treatment of hyperphenylalaninemias such as phenylketonuria (PKU). mRNAs for use in the invention, when administered in vivo, encode human phenylalanine hydroxylase (PAH), functional fragments thereof (e.g., those comprising the catalytic domain or the catalytic domain and the tetramerization domains), and fusion proteins comprising PAH. mRNAs of the invention are preferably encapsulated in lipid nanoparticles (LNPs) to effect efficient delivery to cells and/or tissues in subjects, when administered thereto. mRNA therapies of the invention increase and/or restore deficient levels of PAH expression and/or activity in subjects. mRNA therapies of the invention further decrease abnormal accumulation of phenylalanine associated with deficient PAH activity in subjects.
    Type: Grant
    Filed: November 21, 2018
    Date of Patent: March 26, 2024
    Assignee: ModernaTX, Inc.
    Inventors: Raj Rajendran, Patrick Finn, Paolo G. V. Martini, Ding An, Athanasios Dousis, Kanchana Ravichandran
  • RNA polymerase variants
    Patent number: 11767548
    Abstract: The present disclosure provides, in some aspects, variant RNA polymerases, the use of which increases transcription efficiency while reducing the number of double-stranded RNA contaminates and run-on transcripts produced during an in vitro transcription reaction.
    Type: Grant
    Filed: June 17, 2021
    Date of Patent: September 26, 2023
    Assignee: ModernaTX, Inc.
    Inventors: Amy E. Rabideau, Athanasios Dousis, Kanchana Ravichandran, Elissa Hobert
  • RNA POLYMERASE VARIANTS FOR CO-TRANSCRIPTIONAL CAPPING
    Publication number: 20230104080
    Abstract: The present disclosure provides RNA polymerase variants for high efficiency transcription.
    Type: Application
    Filed: August 1, 2022
    Publication date: April 6, 2023
    Applicant: ModernaTX, Inc.
    Inventors: Athanasios Dousis, Kanchana Ravichandran, Amy E. Rabideau, Margaret Franklin, Kevin Smith, Michelle Lynn Hall
  • RNA polymerase variants for co-transcriptional capping
    Patent number: 11485960
    Abstract: The present disclosure provides RNA polymerase variants for high efficiency transcription.
    Type: Grant
    Filed: May 20, 2021
    Date of Patent: November 1, 2022
    Assignee: ModernaTX, Inc.
    Inventors: Athanasios Dousis, Kanchana Ravichandran, Amy E. Rabideau, Margaret Franklin, Kevin Smith, Michelle Lynn Hall
  • RNA POLYMERASE VARIANTS
    Publication number: 20210395792
    Abstract: The present disclosure provides, in some aspects, variant RNA polymerases, the use of which increases transcription efficiency while reducing the number of double-stranded RNA contaminates and run-on transcripts produced during an in vitro transcription reaction.
    Type: Application
    Filed: June 17, 2021
    Publication date: December 23, 2021
    Applicant: ModernaTX, Inc.
    Inventors: Amy E. Rabideau, Athanasios Dousis, Kanchana Ravichandran, Elissa Hobert
  • RNA POLYMERASE VARIANTS FOR CO-TRANSCRIPTIONAL CAPPING
    Publication number: 20210309976
    Abstract: The present disclosure provides RNA polymerase variants for high efficiency transcription.
    Type: Application
    Filed: May 20, 2021
    Publication date: October 7, 2021
    Applicant: ModernaTX, Inc.
    Inventors: Athanasios Dousis, Kanchana Ravichandran, Amy E. Rabideau, Margaret Franklin, Kevin Smith
  • RNA polymerase variants
    Patent number: 11066686
    Abstract: The present disclosure provides, in some aspects, variant RNA polymerases, the use of which increases transcription efficiency while reducing the number of double-stranded RNA contaminates and run-on transcripts produced during an in vitro transcription reaction.
    Type: Grant
    Filed: October 18, 2019
    Date of Patent: July 20, 2021
    Assignee: ModernaTX, Inc.
    Inventors: Amy E. Rabideau, Athanasios Dousis, Kanchana Ravichandran, Elissa Hobert
  • POLYNUCLEOTIDES ENCODING PHENYLALANINE HYDROXYLASE FOR THE TREATMENT OF PHENYLKETONURIA
    Publication number: 20210040456
    Abstract: This disclosure relates to mRNA therapy for the treatment of hyperphenylalaninemias such as phenylketonuria (PKU). mRNAs for use in the invention, when administered in vivo, encode human phenylalanine hydroxylase (PAH), functional fragments thereof (e.g., those comprising the catalytic domain or the catalytic domain and the tetramerization domains), and fusion proteins comprising PAH. mRNAs of the invention are preferably encapsulated in lipid nanoparticles (LNPs) to effect efficient delivery to cells and/or tissues in subjects, when administered thereto. mRNA therapies of the invention increase and/or restore deficient levels of PAH expression and/or activity in subjects. mRNA therapies of the invention further decrease abnormal accumulation of phenylalanine associated with deficient PAH activity in subjects.
    Type: Application
    Filed: November 21, 2018
    Publication date: February 11, 2021
    Applicant: ModernaTX, Inc.
    Inventors: Raj Rajendran, Patrick Finn, Paolo G.V. Martini, Ding An, Athanasios Dousis, Kanchana Ravichandran
  • RNA POLYMERASE VARIANTS
    Publication number: 20200131550
    Abstract: The present disclosure provides, in some aspects, variant RNA polymerases, the use of which increases transcription efficiency while reducing the number of double-stranded RNA contaminates and run-on transcripts produced during an in vitro transcription reaction.
    Type: Application
    Filed: October 18, 2019
    Publication date: April 30, 2020
    Applicant: ModernaTX, Inc.
    Inventors: Amy E. Rabideau, Athanasios Dousis, Kanchana Ravichandran, Elissa Hobert
  • RNA polymerase variants
    Patent number: 10526629
    Abstract: The present disclosure provides, in some aspects, variant RNA polymerases, the use of which increases transcription efficiency while reducing the number of double-stranded RNA contaminates and run-on transcripts produced during an in vitro transcription reaction.
    Type: Grant
    Filed: June 5, 2019
    Date of Patent: January 7, 2020
    Assignee: ModernaTX, Inc.
    Inventors: Amy E. Rabideau, Athanasios Dousis, Kanchana Ravichandran, Elissa Hobert
  • RNA POLYMERASE VARIANTS
    Publication number: 20190309337
    Abstract: The present disclosure provides, in some aspects, variant RNA polymerases, the use of which increases transcription efficiency while reducing the number of double-stranded RNA contaminates and run-on transcripts produced during an in vitro transcription reaction.
    Type: Application
    Filed: June 5, 2019
    Publication date: October 10, 2019
    Applicant: ModernaTX, Inc.
    Inventors: Amy E. Rabideau, Athanasios Dousis, Kanchana Ravichandran, Elissa Hobert