Abstract: A method for collapsing a microbubble includes applying stimulation to the microbubble during the gradual decrease of the its size. As a result, the microbubble floating in a solution that decreases in size due to the natural dissolution of a gas contained in the microbubble and disappears after a while, has the speed of its size decrease enhanced and causes the microbubble to disappear.

Abstract: An object of the present invention is to provide a medical agent that has an excellent effect on the diseases resulting from one of inflammation and remodeling and that can prevent or treat them in response to various mechanisms of onset and development of the diseases. Thus, the present invention relates to a medical agent for preventing or treating diseases resulting from one of inflammation and remodeling in blood vessel, including nanobubbles.

Abstract: The present invention relates to an ozone water that has the potential to find useful applications in a wide variety of technical fields and is capable of maintaining the effects of wiping out microorganisms such as bacteria, viruses and the like and inhibiting the growth thereof over long periods. The present invention provides ozone nano-bubbles capable of staying in a solution for an extended period of time and a method for producing the ozone nano-bubbles by instantaneously shrinking the diameters of ozone microbubbles contained in an aqueous solution by the application of a physical irritation to the ozone microbubbles in an aqueous solution.

Abstract: An object of the invention is to provide a tissue preservation solution that has excellent tissue-preserving ability and is useful in the field of medicine, medical experiment, etc. Thus, the invention relates to a tissue preservation solution including oxygen nanobubbles.

Abstract: The present invention relates to a preparation for sterilizing or disinfecting a tissue which has an excellent tissue sterilizing or disinfecting ability and is suitable for therapeutic or prophylactic treatment of various diseases caused by a microorganism such as a bacterium or a virus and a method for sterilizing or disinfecting a tissue. The present invention relates to a preparation for sterilizing or disinfecting a tissue and an agent for therapeutic or prophylactic treatment of a periodontal disease, characterized by containing a gas in a nanobubble state. Furthermore, the present invention relates to the above-mentioned preparation for sterilizing or disinfecting a tissue, characterized in that the above-mentioned gas in a nanobubble state is ozone. Furthermore, the present invention relates to a liquid preparation for sterilizing or disinfecting a tissue, characterized by comprising ozone-nanobubble water.

Abstract: An object of the present invention is to provide a medical agent that has an excellent effect on the diseases resulting from one of inflammation and remodeling and that can prevent or treat them in response to various mechanisms of onset and development of the diseases. Thus, the present invention relates to a medical agent for preventing or treating diseases resulting from one of inflammation and remodeling in blood vessel, including nanobubbles.

Abstract: An object of the invention is to provide a tissue preservation solution that has excellent tissue-preserving ability and is useful in the field of medicine, medical experiment, etc. Thus, the invention relates to a tissue preservation solution including oxygen nanobubbles.

Abstract: The present invention relates to a method of producing oxygen nanobubble water that is potentially useful in all technical fields and in particular, has evident bioactive effects upon animals and plants. Oxygen nanobubbles capable of being present in an aqueous solution for a long time, which are produced by applying physical irritation to oxygen-containing microbubbles contained in an aqueous solution, to thereby reduce the bubble diameter of the microbubble abruptly and a method for forming such oxygen nanobubbles are provided.

Abstract: A method for collapsing a microbubble characterized in that it comprises applying stimulation to the microbubble in the step of the gradual decrease of the its size, in a course wherein the microbubble floating in a solution decreases in its size due to the natural dissolution of a gas contained in the microbubble and disappears after a while, to thereby enhance the speed of the its size decrease and cause the microbubble to disappear.

Abstract: The present invention relates to an ozone water that has the potential to find useful applications in a wide variety of technical fields and is capable of maintaining the effects of wiping out microorganisms such as bacteria, viruses and the like and inhibiting the growth thereof over long periods. The present invention provides ozone nano-bubbles capable of staying in a solution for an extended period of time and a method for producing the ozone nano-bubbles by instantaneously shrinking the diameters of ozone microbubbles contained in an aqueous solution by the application of a physical irritation to the ozone microbubbles in an aqueous solution.

Abstract: The present invention relates to a method of forming nanobubbles that have potential utility in every industrial application and that impart special functions, especially to water. The present invention is a method of forming nanobubbles by applying physical irritation to microbubbles contained in a liquid so that the microbubbles are abruptly contracted to form nanobubbles.