Patents by Inventor Kaneto Uekama
Kaneto Uekama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6596706Abstract: The present invention relates to a compound represented by formula (1): wherein Q, which may have a substituent, represents an aryl group, a heterocyclic group, a diarylmethyl group, or an aralkyl group; R, which may have a substituent, represents a bicyclic nitrogen-containing heterocyclic group or a phenyl group; and Z represents a C1-C3 alkylene group, a C2-C4 alkenylene group, a C1-C3 alkylene group having one hydroxyl group, a carbonyl moiety, a C1-C2 alkylene group containing one carbonyl moiety at one end or an intermediate position of the carbon chain, or an oxalyl group; or salts thereof and a piperazine-cyclodextrin complex combined with a water-soluble cyclodextrin derivative. The complex exhibits enhanced water solubility, excellent stability, and low topical stimulation and is useful as a therapeutic agent for circulatory diseases and diseases of the brain region.Type: GrantFiled: May 8, 2000Date of Patent: July 22, 2003Assignee: Daiichi Pharmaceutical Co., Ltd.Inventors: Masahiko Kikuchi, Yukihiko Nagase, Kaneto Uekama
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Patent number: 5904929Abstract: A pharmaceutical composition for trans-mucosal or transdermal administration wherein a per-C.sub.2-18 acylated cyclodextrin is used as a drug reservoir or carrier. The composition can be used safely and exhibits excellent drug release behavior.Type: GrantFiled: July 2, 1997Date of Patent: May 18, 1999Assignee: Janssen Pharmaceutica, N.V.Inventors: Kaneto Uekama, Fumitoshi Hirayama, Akira Kondo, Masaaki Ohta, Yasuhiro Okamoto, Haruo Kunihiro
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Patent number: 5888827Abstract: Cholesterol in low-density lipoprotein (LDL) or very low-density lipoprotein (VLVL) in a sample is determined in the presence of a sugar compound and/or a protein-solubilizing agent.Type: GrantFiled: November 19, 1996Date of Patent: March 30, 1999Assignee: Kyowa Medex Co., Ltd.Inventors: Norihiko Kayahara, Toshio Tatano, Eiko Shutoh, Hiroyuki Sugiuchi, Tetsumi Irie, Kaneto Uekama
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Patent number: 5888755Abstract: Provided is a method of determining the amount of cholesterol in high-density lipoprotein (HDL), which comprises reacting an HDL-containing sample with cholesterol esterase and cholesterol oxidase or cholesterol dehydrogenase in the presence of a reagent for aggregating lipoproteins- except HDL, and determining the amount of hydrogen peroxide or reductive co-enzyme formed therein.Type: GrantFiled: November 10, 1997Date of Patent: March 30, 1999Assignee: Kyowa Medex Co., Ltd.Inventors: Kazuhito Miyauchi, Akira Miike, Eiko Shutoh, Hiroyuki Sugiuchi, Tetsumi Irie, Kaneto Uekama, Susumu Ohsawa
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Patent number: 5854281Abstract: The present invention provides a preparation for percutaneous absorption comprising as an effective component a prostaglandin I.sub.2 derivative and a fatty acid or a derivative thereof, or a mixture of two or more of these, which has high percutaneous permeability of the PGI.sub.2 derivative. Particularly, the present invention provides a preparation for percutaneous absorption comprising 5,6,7-trinor-4,8-inter-m-phenylene PGI.sub.2 derivative and a C.sub.6 -C.sub.24 fatty acid, a salt thereof or an ester thereof, or a mixture of two or more of these, which has high percutaneous permeability of the PGI.sub.2 derivative. This preparation for percutaneous absorption suggests a possibility to last pharmacological effects and to reduce side effects. Thus, the preparation is expected to be used for therapy of various diseases, aiming at topical and systemic actions.Type: GrantFiled: December 10, 1996Date of Patent: December 29, 1998Assignee: Toray Industries, Inc.Inventors: Kaneto Uekama, Tetsumi Irie, Michio Hara, Yasuhide Horiuchi
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Patent number: 5736406Abstract: Provided are a method of determining the amount of cholesterol in high-density lipoprotein (HDL), which comprises measuring the amount of cholesterol in low-density lipoprotein (LDL), very-low-density lipoprotein (VLDL) and chylomicron (CM) in a sample in the presence of a sugar compound and/or a protein solubilizing agent, and calculating the difference between the amount of cholesterol in LDL, VLDL and CM and the total amount of cholesterol in the sample, and a method of determining the amount of cholesterol in HDL, which comprises measuring the amount of cholesterol in HDL in a sample in the presence of a sugar compound and/or a protein solubilizing agent.Type: GrantFiled: November 2, 1995Date of Patent: April 7, 1998Assignee: Kyowa Medex Co., Ltd.Inventors: Kazuhito Miyauchi, Norihiko Kayahara, Toshio Tatano, Eiko Shutoh, Hiroyuki Sugiuchi, Tetsumi Irie, Kaneto Uekama, Susumu Ohsawa
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Patent number: 5691159Abstract: Provided is a method of determining the amount of cholesterol in high-density lipoprotein (HDL), which comprises reacting an HDL-containing sample with cholesterol esterase and cholesterol oxidase or cholesterol dehydrogenase in the presence of a reagent for aggregating lipoproteins except HDL, and determining the amount of hydrogen peroxide or reductive co-enzyme formed therein.Type: GrantFiled: November 2, 1995Date of Patent: November 25, 1997Assignee: Kyowa Medex Co., Ltd.Inventors: Kazuhito Miyauchi, Akira Miike, Eiko Shutoh, Hiroyuki Sugiuchi, Tetsumi Irie, Kaneto Uekama, Susumu Ohsawa
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Patent number: 5382567Abstract: Aromatic compositions which comprise perfumes included in cyclodextrins whose inclusion ability depends on a pH of a solution containing the perfumes and cyclodextrins and pH-adjusting substances whereby a release rate of the perfume can be controlled, are described. Aromatic compositions are also disclosed, which comprise perfumes coated or covered with materials whose solubility depends on the pH of a solution containing the coated perfumes, and a pH-adjusting substance to change the pH as desired. Methods for controlling the release rate of the perfumes are also described.Type: GrantFiled: April 27, 1993Date of Patent: January 17, 1995Assignee: Wakunaga Seiyaku Kabushiki KaishaInventors: Toru Fuwa, Kaneto Uekama
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Patent number: 5238915Abstract: Aromatic compositions which comprise perfumes included in cyclodextrins whose inclusion ability depends on a pH of a solution containing the perfumes and cyclodextrins and pH-adjusting substances whereby a release rate of the perfume can be controlled, are described. Aromatic compositions are also disclosed, which comprise perfumes coated or covered with materials whose solubility depends on the pH of a solution containing the coated perfumes, and a pH-adjusting substance to change the pH as desired. Methods for controlling the release rate of the perfumes are also described.Type: GrantFiled: February 6, 1992Date of Patent: August 24, 1993Assignee: Wakunaga Seiyaku K.K.Inventors: Toru Fuwa, Kaneto Uekama
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Patent number: 4877774Abstract: Crystalline complexes of steroid hormones with gamma-cyclodextrin are prepared by mixing the components together. Tablets can be formed from the complexes, which can be administered by contact with the mucosa to provide effective transfer of the hormones into the systemic circulation, gradually eliminating the hormones therefrom.Type: GrantFiled: September 9, 1987Date of Patent: October 31, 1989Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Josef Pitha, Mitchell Harman, Kaneto Uekama
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Patent number: 4869904Abstract: Now is provided a new sustained release drug preparation comprising such an inclusion complex of a medical compound with a hydrophobic cyclodextrin derivative, e.g. ethylated cyclodextrins, which sustains or retards the dissolution and release of the medical compound at a controlled rate from the inclusion complex and hence from the drug preparation containing the inclusion complex, so as to maintain the concentration of the medical compound in blood at an effective level for prolonged time. This drug preparation may further contain a second type of an inclusion complex of the medical compound with a hydrophilic cyclodextrin or hydrophilic cyclodextrin derivative, in mixture with the first type of the inclusion complex of the medical compound with a hydrophobic cyclodextrin derivative, to maintain the controlled release of the medical compound from the drug.Type: GrantFiled: December 2, 1987Date of Patent: September 26, 1989Assignee: Nisshin Flour Milling Co., Ltd.Inventors: Kaneto Uekama, Yoshiyuki Tahara, Takanori Ijitsu, Tadashi Yamada
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Patent number: 4565807Abstract: The invention relates to a new medicinal composition containing .alpha.-[3-chloro-4-(3-pyrrolin-1-yl)-phenyl]-propionic acid as the pharmacologically active ingredient, having analgesic and antiinflammatory properties, which composition has markedly improved properties, particularly with respect to taste and stability.Type: GrantFiled: July 11, 1983Date of Patent: January 21, 1986Assignee: Ciba-Geigy CorporationInventors: Kaneto Uekama, Mikio Hanafusa, Masashi Tatsumi, Tohru Hibi