Abstract: The present invention relates to a novel use of N-(4-isopropylphenyl)-5-amino-isoindoline for diagnosing Alzheimer's disease and quantifying amyloid in the brain.

Abstract: The present invention relates to a novel use of N-(4-isopropylphenyl)-5-amino-isoindoline for diagnosing Alzheimer's disease and quantifying amyloid in the brain.

Abstract: Flumazenil (FMZ) is labeled with fluorine(F)-18 to obtain F-18-flumazenil. F-18-flumazenil can be strongly combined with type-A acceptor of gamma-aminobutyric acid (GABAA) in brain for tracing. The time and temperature for labeling is saved and lowered. The toxic chemical, acetonitrile, used in separation and purification can be prevented. The present invention has a simplified procedure for evaluating mental disease medicines in a short time. Moreover, time for developing medicines for treating related diseases of the central nervous system can be reduced.

Abstract: A process of evaluating blood-brain barrier permeability of a stroke rat by using fluorescent substance is disclosed. This process uses an Evans blue dye having spontaneous fluorescence properties, in combination with the use of a new non-invasive in vivo imaging system (IVIS), to obtain fluorescent signals so as to assess the change in the blood-brain barrier permeability of rodents after a cerebral artery stroke model surgery. In operation, an Evans blue dye is injected into a stroke rat of middle cerebral artery occlusion model. A non-invasive in vivo imaging system is used to detect the fluorescence distribution of the whole brain, and obtain images combined by the fluorescence images and optical images for the whole brain tissue. Thereby, the change in the blood-brain barrier permeability of the stroke rat can be completely realized.

Abstract: The present invention provides a method of preparing [123I]Iodooctyl fenbufen amide with a radiochemical yield of 15%, a specific activity of 37 GBq/?mol and radiochemical purity of 95%. The present invention further provides a method of applying [123I]Iodooctyl fenbufen amide as tracer of single photon emission computer tomography (SPECT) to estimate the distribution of cyclooxygenase. By the binding characteristics of the iodine isotope-labeled compounds and the positive correlation of inflammation to tumor lesion, the present invention can estimate the tumor development and metastasis.

Abstract: The present invention provides a method of preparing [123I]Iodooctyl fenbufen amide with a radiochemical yield of 15%, a specific activity of 37 GBq/?mol and radiochemical purity of 95%. The present invention further provides a method of applying [123I]Iodooctyl fenbufen amide as tracer of single photon emission computer tomography (SPECT) to estimate the distribution of cyclooxygenase. By the binding characteristics of the iodine isotope-labeled compounds and the positive correlation of inflammation to tumor lesion, the present invention can estimate the tumor development and metastasis.

Abstract: A process of evaluating blood-brain barrier permeability of a stroke rat by using fluorescent substance is disclosed. This process uses an Evans blue dye having spontaneous fluorescence properties, in combination with the use of a new non-invasive in vivo imaging system (IVIS), to obtain fluorescent signals so as to assess the change in the blood-brain barrier permeability of rodents after a cerebral artery stroke model surgery. In operation, an Evans blue dye is injected into a stroke rat of middle cerebral artery occlusion model. A non-invasive in vivo imaging system is used to detect the fluorescence distribution of the whole brain, and obtain images combined by the fluorescence images and optical images for the whole brain tissue. Thereby, the change in the blood-brain barrier permeability of the stroke rat can be completely realized.

Abstract: A method is provided to label dopamine D2 receptors at striatum and areas outside of striatum. A radiosynthesized ligand of iodine(I)-123-Epidepride is used. The I-123-Epidepride can be strongly bonded to the D2 receptor and has a rare characteristic of non-specificity. Hence, it is suitable for developing a tracer for areas outside of striatum, where D2 receptor densities are low. Besides, I-123-Epidepride can be passed through blood brain barrier and has a high affinity to an animal's brain, so it can be used to develop medicines for diagnosing schizophrenia.

Abstract: A method is provided for fabricating I-123-IBOX. I-123-IBOX is used for SPECT of brain. During the fabrication, radioactivity of reaction vial and purification column can be detected. Thus, I-123-IBOX can be obtained in a short time through a simple process with reduced radioactive harms.

Abstract: Disclosed is an automatic process for synthesizing F-18-FDDNP. The automatic process includes a preparation subroutine and a synthesis subroutine. The automatic process is efficient and simple. That is, it can be used to produce a large amount of chemicals in a short period of time. Furthermore, it reduces the risk of human exposure to radiation.

Abstract: There is disclosed a method for using 123I to radiolabel SnADAM become an serotonin transporter radiotracer(123I -ADAM). At first, there is provided SnADAM solution via mixing SnADAM with ethanol. The SnADAM solution is shaken and further mixed with thin KI solution. The SnADAM solution is mixed with 123I-NH4I solution and H2O2 solution. The SnADAM-123I-NH4I—H2O2 mixture is kept still. Later, the SnADAM solution is mixed with NaHSO3 solution, and the mixture is shaken and further mixed with buffer solution of saturated Na2HPO4. The SnADAM solution is filled in an Accubond C8 column. The Accubond C8 column is washed with sterile water for injection to isolate non-reacting 123I ions. The Accubond C8 column is washed with ethanol, thus providing 123I-ADAM. The 123I-ADAM is blended in normal saline mixture. Millipore Millex GV is used to filter impurities and bacteria from the 123I-ADAM solution.

Abstract: A labelling method and system are disclosed for correlating multiple outstanding requests to utilize a shared resource issued by a particular master of a computer system. The labelling system includes a memory for storing an assigned indication corresponding to each label assigned by each master of a computer system. The memory is also for indicating a label available for assignment which is unique over each outstanding, unsatisfied request to utilize the shared resource issued by each master of the computers system. The labelling system also includes a first circuit which is responsive to the unique label indicated by the memory. The first circuit is provided for assigning the unique label indicated by the memory to a request to utilize the shared resource issued by the particular master in which the labelling system is located.