Abstract: Systems and methods are provided for operation of a sleep-lab. A central processor provides connectivity between sleep-lab personnel, sleep-lab equipment, monitoring and analysis personnel and the patient. The sleep-lab supports at-home treatment and diagnostics, monitor-only sleep labs, and conventional sleep-labs. Monitoring and analysis, performed by the real-time monitor, scorer and over-reader, interpreter, and follow-up analyst, may be performed at a central location or disbursed throughout the world to take advantage of time-shifting and/or other resources. A central processor provides security and connectivity to facilitate the data exchange between data sources and monitoring and analysis facilities. A sleep-lab communication protocol helps to ensure a loss-less transfer of data over an interruptible network connection. A sleep-lab interface provides data conversion and accounting processes.