Patents by Inventor Kangshan LI

Kangshan LI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • YAP PROTEIN INHIBITING POLYPEPTIDE AND APPLICATION THEREOF
    Publication number: 20200062811
    Abstract: Provided in the present invention are a YAP protein inhibiting polypeptide and application thereof. In particular, the present invention obtains a key binding site of YAP protein and TEAD, screens a polypeptide with best YAP inhibitory activity and modifies the polypeptide, such as adding a disulfide linkage, replacing an amino acid, removing and/or adding (for example, adding a cell-penetrating element), and finally screens and verifies the obtaining of a series of polypeptides with YAP protein activity inhibiting effect and good stability. Experiments show that the polypeptide of the present invention can effectively inhibit the binding activity between YAP protein and TEAD, thus providing good therapeutic effect on digestive tract tumors (especially liver cancer).
    Type: Application
    Filed: November 6, 2019
    Publication date: February 27, 2020
    Inventor: Kangshan LI
  • YAP protein inhibiting polypeptide and application thereof
    Patent number: 10526385
    Abstract: Provided in the present invention are a YAP protein inhibiting polypeptide and application thereof. In particular, the present invention obtains a key binding site of YAP protein and TEAD, screens a polypeptide with best YAP inhibitory activity and modifies the polypeptide, such as adding a disulfide linkage, replacing an amino acid, removing and/or adding (for example, adding a cell-penetrating element), and finally screens and verifies the obtaining of a series of polypeptides with YAP protein activity inhibiting effect and good stability. Experiments show that the polypeptide of the present invention can effectively inhibit the binding activity between YAP protein and TEAD, thus providing good therapeutic effect on digestive tract tumors (especially liver cancer).
    Type: Grant
    Filed: October 17, 2014
    Date of Patent: January 7, 2020
    Assignee: BAO KANG BIOMEDICAL HEALTHCARE INC
    Inventor: Kangshan Li
  • High activity tumour inhibitor and preparation method and use thereof
    Patent number: 10441628
    Abstract: Provided in the present invention are a YAP protein inhibiting polypeptide and application thereof. In particular, the present invention obtains a key binding site of YAP protein and TEAD, screens a polypeptide with best YAP inhibitory activity and modifies the polypeptide, such as adding a disulfide linkage, replacing an amino acid, removing and/or adding (for example, adding a cell-penetrating element), and finally screens and verifies the obtaining of a series of polypeptides with YAP protein activity inhibiting effect and good stability. Experiments show that the polypeptide of the present invention can effectively inhibit the binding activity between YAP protein and TEAD, thus providing good therapeutic effect on digestive tract tumors (especially liver cancer).
    Type: Grant
    Filed: October 15, 2015
    Date of Patent: October 15, 2019
    Assignee: BAO KANG BIOMEDICAL HEALTHCARE INC
    Inventor: Kangshan Li
  • HIGH ACTIVITY TUMOUR INHIBITOR AND PREPARATION METHOD AND USE THEREOF
    Publication number: 20170319648
    Abstract: Provided in the present invention are a YAP protein inhibiting polypeptide and application thereof. In particular, the present invention obtains a key binding site of YAP protein and TEAD, screens a polypeptide with best YAP inhibitory activity and modifies the polypeptide, such as adding a disulfide linkage, replacing an amino acid, removing and/or adding (for example, adding a cell-penetrating element), and finally screens and verifies the obtaining of a series of polypeptides with YAP protein activity inhibiting effect and good stability. Experiments show that the polypeptide of the present invention can effectively inhibit the binding activity between YAP protein and TEAD, thus providing good therapeutic effect on digestive tract tumors (especially liver cancer).
    Type: Application
    Filed: October 15, 2015
    Publication date: November 9, 2017
    Applicant: BAO KANG BIOMEDICAL HEALTHCARE INC
    Inventor: Kangshan LI
  • YAP PROTEIN INHIBITING POLYPEPTIDE AND APPLICATION THEREOF
    Publication number: 20160272690
    Abstract: Provided in the present invention are a YAP protein inhibiting polypeptide and application thereof. In particular, the present invention obtains a key binding site of YAP protein and TEAD, screens a polypeptide with best YAP inhibitory activity and modifies the polypeptide, such as adding a disulfide linkage, replacing an amino acid, removing and/or adding (for example, adding a cell-penetrating element), and finally screens and verifies the obtaining of a series of polypeptides with YAP protein activity inhibiting effect and good stability. Experiments show that the polypeptide of the present invention can effectively inhibit the binding activity between YAP protein and TEAD, thus providing good therapeutic effect on digestive tract tumors (especially liver cancer).
    Type: Application
    Filed: October 17, 2014
    Publication date: September 22, 2016
    Applicant: BAO KANG BIOMEDICAL HEALTHCARE INC
    Inventor: Kangshan LI