Abstract: A hypoallergenic garment is provided that offers relief by achieving a desirable cooling or heating effect in an individual experiencing pain or discomfort. It can be used for treatment of conditions such as itching, burning, yeast or bacterial infection, urethral pain, inflammation, urinary tract infections, dermatitis, vaginal varicosity, menopausal perspiration, post-surgery swelling, edema due to a sports injury, swelling due to trauma, damage to the perineum, menopausal pain and combinations thereof.