Patents by Inventor Kanji Meghpara
Kanji Meghpara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10849846Abstract: Self-regulating, osmotic, floating gastroretentive compositions that provide extended release, delayed release, and/or delayed extended release of active pharmaceutical agents, as well as, optionally, immediate release of the same or a different active pharmaceutical agent, are provided here. The gastroretentive compositions of the disclosure comprise a swellable, extended release, multilayer core comprising a push layer and a pull layer; a water-insoluble permeable elastic membrane surrounding the multilayer core; and an orifice (e.g., a laser-drilled orifice, a manually drilled orifice) on the pull-layer side of the dosage form. The gastric retention of the composition is controlled by rapid floating of the composition and expansion of the membrane.Type: GrantFiled: June 29, 2020Date of Patent: December 1, 2020Assignee: KASHIV BIOSCIENCES, LLCInventors: Navnit H. Shah, Dipen Desai, Wantanee Phuapradit, Jaydeep Vaghashiya, Kanji Meghpara
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Publication number: 20200337998Abstract: The present disclosure is directed to floating gastroretentive dosage forms with prolonged gastric residence time. The disclosure also provides rapidly expanding sustained release or combined immediate release and sustained release formulations comprising drugs that require targeted release in the proximal gastrointestinal tract for maximum therapeutic benefit. The rapidly expanding floating gastroretentive dosage forms comprise a permeable elastic membrane providing desired characteristics for drug release and mechanical strength to maintain tablet integrity.Type: ApplicationFiled: June 18, 2018Publication date: October 29, 2020Applicant: KASHIV PHARMA LLCInventors: Kanji Meghpara, Harpreet Kaur Sandhu, Ashish Chatterji, Navnit H. Shah, Wantanee Phuapradit, Dipen Desai, Jaydeep Vaghashiya
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Publication number: 20200330368Abstract: Self-regulating, osmotic, floating gastroretentive compositions that provide extended release, delayed release, and/or delayed extended release of active pharmaceutical agents, as well as, optionally, immediate release of the same or a different active pharmaceutical agent, are provided here. The gastroretentive compositions of the disclosure comprise a swellable, extended release, multilayer core comprising a push layer and a pull layer; a water-insoluble permeable elastic membrane surrounding the multilayer core; and an orifice (e.g., a laser-drilled orifice, a manually drilled orifice) on the pull-layer side of the dosage form. The gastric retention of the composition is controlled by rapid floating of the composition and expansion of the membrane.Type: ApplicationFiled: June 29, 2020Publication date: October 22, 2020Applicant: KASHIV BIOSCIENCES, LLCInventors: Navnit H. Shah, Dipen Desai, Wantanee Phuapradit, Jaydeep Vaghashiya, Kanji Meghpara
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Publication number: 20200261359Abstract: The present disclosure is directed to floating gastroretentive dosage forms with prolonged gastric residence time. The disclosure also provides rapidly expanding sustained release or combined immediate release and sustained release formulations comprising drugs that require targeted release in the proximal gastrointestinal tract for maximum therapeutic benefit. The rapidly expanding floating gastroretentive dosage forms comprise a permeable elastic membrane providing desired characteristics for drug release and mechanical strength to maintain tablet integrity.Type: ApplicationFiled: May 6, 2020Publication date: August 20, 2020Applicant: KASHIV BIOSCIENCES, LLCInventors: Kanji Meghpara, Jaydeep Vaghashiya, Navnit H. Shah, Dipen Desai, Wantanee Phuapradit, Harpreet Kaur Sandhu, Siva Ram Kiran Vaka, Namdev B. Shelke, Ashish Chatterji
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Patent number: 10744083Abstract: Self-regulating, osmotic, floating gastroretentive compositions that provide extended release, delayed release, and/or delayed extended release of active pharmaceutical agents, as well as, optionally, immediate release of the same or a different active pharmaceutical agent, are provided here. The gastroretentive compositions of the disclosure comprise a swellable, extended release, multilayer core comprising a push layer and a pull layer; a water-insoluble permeable elastic membrane surrounding the multilayer core; and an orifice (e.g., a laser-drilled orifice, a manually drilled orifice) on the pull-layer side of the dosage form. The gastric retention of the composition is controlled by rapid floating of the composition and expansion of the membrane. The rapid swelling of the composition to a size greater than the size of the pyloric sphincter is due to the presence of an osmogen.Type: GrantFiled: June 27, 2019Date of Patent: August 18, 2020Assignee: KASHIV BIOSCIENCES, LLCInventors: Navnit H. Shah, Wantanee Phuapradit, Dipen Desai, Jaydeep Vaghashiya, Kanji Meghpara
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Publication number: 20200179267Abstract: Self-regulating, osmotic, floating gastroretentive compositions that provide extended release, delayed release, and/or delayed extended release of active pharmaceutical agents, as well as, optionally, immediate release of the same or a different active pharmaceutical agent, are provided here. The gastroretentive compositions of the disclosure comprise a swellable, extended release, multilayer core comprising a push layer and a pull layer; a water-insoluble permeable elastic membrane surrounding the multilayer core; and an orifice (e.g., a laser-drilled orifice, a manually drilled orifice) on the pull-layer side of the dosage form. The gastric retention of the composition is controlled by rapid floating of the composition and expansion of the membrane.Type: ApplicationFiled: January 31, 2020Publication date: June 11, 2020Applicant: KASHIV BIOSCIENCES, LLCInventors: Navnit H. Shah, Wantanee Phuapradit, Dipen Desai, Jaydeep Vaghashiya, Kanji Meghpara
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Publication number: 20200155446Abstract: Self-regulating, osmotic, floating gastroretentive compositions that provide extended release, delayed release, and/or delayed extended release of active pharmaceutical agents, as well as. optionally, immediate release of the same or a different active pharmaceutical agent, are provided here. The gastroretentive compositions of the disclosure comprise a swellable, extended release, multilayer core comprising a push layer and a pull layer; a water-insoluble permeable elastic membrane surrounding the multilayer core; and an orifice (e.g., a laser-drilled orifice, a manually drilled orifice) on the pull-layer side of the dosage form. The gastric retention of the composition is controlled by rapid floating of the composition and expansion of the membrane. The rapid swelling of the composition to a size greater than the size of the pyloric sphincter is due to the presence of an osmogen.Type: ApplicationFiled: June 27, 2019Publication date: May 21, 2020Applicant: KASHIV BIOSCIENCES, LLCInventors: Navnit H. Shah, Wantanee Phuapradit, Dipen Desai, Jaydeep Vaghashiya, Kanji Meghpara
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Patent number: 10632113Abstract: Disclosed are solid oral pharmaceutical compositions that that are intended to provide protection against overdose and tampering, as well as abuse deterrence. The compositions contain a plurality of granules or multi-particulates. A first population of multi particulates contains an API or drug susceptible to abuse, a polymer matrix, and an outer coating that contains a cationic pH dependent polymer. These multi particulates also contain a plasticizer and a surfactant. A second population of multi particulates contains a viscosity building polymer and an alkaline buffering agent. Compositions may further include a disintegrant, and/or additional viscosity building polymers and/or alkaline buffering agents and/or ion exchange polymers. Also disclosed are the methods of making and using the compositions.Type: GrantFiled: February 5, 2015Date of Patent: April 28, 2020Assignee: KASHIV BIOSCIENCES, LLCInventors: Siva Ram Kiran Vaka, Ashish Chatterji, Dipen Desai, Wantanee Phuapradit, Navnit H. Shah, Atsawin Thongsukmak, Kanji Meghpara
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Publication number: 20190343957Abstract: Disclosed are methods of making oral pharmaceutical compositions that contain substantially crush-resistant drug-containing microparticles. The microparticles may contain an active pharmaceutical agent, a polymer and a plasticizer. The microparticles may be uncoated (so as to impart an immediate release profile) or coated so as to impart an extended-release (ER), delayed release (DR) or delayed-extended release (DER) profile. One or more of the populations of microparticles may be coated with a taste-masking composition. The methods may produce oral compositions such as orally disintegrating tablets that contain one or more these types of microparticles in order to further customize the release profile. Also disclosed are the oral compositions, per se, and methods of using same for their intended purposes.Type: ApplicationFiled: July 26, 2019Publication date: November 14, 2019Applicant: Kashiv BioSciences, LLCInventors: Siva Ram Kiran Vaka, Dipen Desai, Wantanee Phuapradit, Navnit H. Shah, Kanji Meghpara
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Publication number: 20190282508Abstract: The presently disclosed subject matter provides solid, oral, extended release, pharmaceutical particulate and multi-particulate dosage forms with abuse deterrent and overdose protection features/characteristics comprising at least one or two populations of particulates. In certain embodiments, the first population of particulates comprises a therapeutically effective amount of at least one opioid embedded in a polymer matrix, a primary functional coat layer (FC 1), a secondary functional coat 2 coat layer (FC 2), and an over coat; wherein FC 1 comprises a nonionic water-insoluble polymer and, optionally, at least one of a cationic polymer, a nonionic water-soluble polymer, and a water-soluble plasticizer; FC 2 comprises a cationic polymer and, optionally, a nonionic water-insoluble polymer; and the over coat comprises a nonionic water-soluble polymer. The second population of particulates comprises an alkaline agent and, optionally, a pH-stabilizing agent.Type: ApplicationFiled: February 1, 2017Publication date: September 19, 2019Applicant: KASHIV PHARMA LLCInventors: Navnit H. Shah, Wantanee Phuapradit, Dipen Desai, Kiran Siva Ram Vaka, Kanji Meghpara, Atsawin Thongsukmak
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Patent number: 10406234Abstract: Disclosed are methods of making oral pharmaceutical compositions that contain substantially crush resistant drug containing microparticles. The microparticles may contain an active pharmaceutical agent, a polymer and a plasticizer. The microparticles may be un-coated (so as to impart an immediate release profile) or coated so as to impart an extended release (ER), delayed release (DR) or delayed extended release (DER) profile. One or more of the populations of microparticles may be coated with a taste masking composition. The methods may produce oral compositions such as orally disintegrating tablets that contain one or more these types of microparticles in order to further customize the release profile. Also disclosed are the oral compositions, per se, and methods of using same for their intended purposes.Type: GrantFiled: March 24, 2015Date of Patent: September 10, 2019Assignee: Kashiv BioSciences, LLCInventors: Siva Ram Kiran Vaka, Dipen Desai, Wantanee Phuapradit, Navnit H. Shah, Kanji Meghpara
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Publication number: 20190054031Abstract: The presently disclosed subject matter provides a solid immediate release pharmaceutical multi-particulate dosage form containing at least two different populations of particulates. In certain embodiments, the immediate release pharmaceutical dosage forms contain at least three different populations of multi-particulates. Each population of particulates is designed for a specific function to accomplish the desired combination of abuse deterrence and overdose protection.Type: ApplicationFiled: September 30, 2016Publication date: February 21, 2019Applicant: KASHIV PHARMA LLCInventors: Navnit H. Shah, Wantanee Phuapradit, Dipen Desai, Siva Ram Kiran Vaka, Kanji Meghpara
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Publication number: 20180296486Abstract: The presently disclosed subject matter provides a solid immediate release pharmaceutical particulate dosage form containing one population of particulates, and/or a solid immediate release pharmaceutical multi-particulate dosage form containing at least two different populations of particulates. In certain embodiments, the immediate release pharmaceutical dosage forms contain at least three different populations of multi-particulates. Each population of particulates is designed for a specific function to accomplish the desired combination of abuse deterrence and overdose protection.Type: ApplicationFiled: April 18, 2018Publication date: October 18, 2018Applicant: KASHIV PHARMA, LLCInventors: Navnit H. Shah, Wantanee Phuapradit, Dipen Desai, Siva Ram Kiran Vaka, Kanji Meghpara, Atsawin Thongsukmak
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Publication number: 20170173157Abstract: Disclosed are methods of making oral pharmaceutical compositions that contain substantially crush resistant drug containing microparticles. The microparticles may contain an active pharmaceutical agent, a polymer and a plasticizer. The microparticles may be un-coated (so as to impart an immediate release profile) or coated so as to impart an extended release (ER), delayed release (DR) or delayed extended release (DER) profile. One or more of the populations of microparticles may be coated with a taste masking composition. The methods may produce oral compositions such as orally disintegrating tablets that contain one or more these types of microparticles in order to further customize the release profile. Also disclosed are the oral compositions, per se, and methods of using same for their intended purposes.Type: ApplicationFiled: March 24, 2015Publication date: June 22, 2017Applicant: Kashiv Pharma, LLCInventors: Siva Ram Kiran VAKA, Dipen DESAI, Wantanee PHUAPRADIT, Navnit H. SHAH, Kanji MEGHPARA
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Publication number: 20160346274Abstract: Disclosed are solid oral pharmaceutical compositions that that are intended to provide protection against overdose and tampering, as well as abuse deterrence. The compositions contain a plurality of granules or multi-particulates. A first population of multi particulates contains an API or drug susceptible to abuse, a polymer matrix, and an outer coating that contains a cationic pH dependent polymer. These multi particulates also contain a plasticizer and a surfactant. A second population of multi particulates contains a viscosity building polymer and an alkaline buffering agent. Compositions may further include a disintegrant, and/or additional viscosity building polymers and/or alkaline buffering agents and/or ion exchange polymers. Also disclosed are the methods of making and using the compositions.Type: ApplicationFiled: February 5, 2015Publication date: December 1, 2016Applicant: KASHIV PHARMA, LLCInventors: Siva Ram Kiran Vaka, Ashish Chatterji, Dipen Desai, Wantanee Phuapradit, Navnit H. Shah, Atsawin Tohngsukmak, Kanji Meghpara
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Publication number: 20140065213Abstract: The present invention is directed to twice daily sustained release pharmaceutical composition of paracetamol having an immediate release phase of paracetamol and a sustained release phase of paracetamol, said composition having unique and advantageous pharmacokinetic properties and a pharmaceutical composition comprising only a sustained release phase of paracetamol having unique and advantageous pharmacokinetic properties.Type: ApplicationFiled: May 4, 2012Publication date: March 6, 2014Applicant: GlaxoSmithKline, LLCInventors: Carla Valenti Buan, Dongzhou Liu, Kanji Meghpara
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Patent number: 7943167Abstract: In various embodiments of the present invention, a capsule is provided including a hydrophobic inner layer and at least one hydrophilic outer layer. The hydrophobic layer may include a hydrophilic component such as an active pharmaceutical ingredient (API) which may be fully encapsulated, partially encapsulated or part of an adsorption complex. Such capsules experience no or minimal cracking or breaking in the outer layer.Type: GrantFiled: March 28, 2006Date of Patent: May 17, 2011Assignee: McNeil-PPC, Inc.Inventors: Neema Kulkarni, Kanji Meghpara
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Publication number: 20070134493Abstract: Several embodiments of the present invention provide a capsule including a hydrophobic inner core layer and at least one hydrophilic outer layer. The outer layer may be seamless and may include at least one hygroscopic polyol and at least one polyol with a low hygroscopicity. The at least one outer layer may include at least one film or gel forming agent. Such capsules are stable and experience minimal or no degradation under accelerated stability conditions.Type: ApplicationFiled: December 8, 2005Publication date: June 14, 2007Inventor: Kanji Meghpara
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Publication number: 20060222701Abstract: In various embodiments of the present invention, a capsule is provided including a hydrophobic inner layer and at least one hydrophilic outer layer. The hydrophobic layer may include a hydrophilic component such as an active pharmaceutical ingredient (API) which may be fully encapsulated, partially encapsulated or part of an adsorption complex. Such capsules experience no or minimal cracking or breaking in the outer layer.Type: ApplicationFiled: March 28, 2006Publication date: October 5, 2006Inventors: Neema Kulkarni, Kanji Meghpara