Abstract: An apparatus capable of producing a laminated microcapsule sheet through transferring with high productivity of a drug solution of high viscosity accurately as much as a given weight while avoiding run-off from an enteric layer. There is provided an apparatus comprising edible film holding means (1) for holding an edible film (4); solution transfer printing means (2) equipped with multiple needles (22) for transfer printing of a solution containing any of materials; and a pallet (3) for applying of the solution containing any of materials to the solution transfer printing means (2).

Abstract: Self-dissolving needle-like or filamentous shape percutaneously absorbable preparations, by which inherently poorly absorbable drugs into the body through the skin is efficiently administered. The preparations are made of at least one material selected from the group consisting of proteins, polysaccharides, polyvinyl alcohols, carboxyvinyl polymers and sodium polyacrylic acids. An active substance contained therein is released in a sustained-release fashion (1) by forming a water-insoluble layer on its surface, (2) by holding the active substance in porous materials, or (3) by imparting a long-acting characteristic to the active substance. The present invention also provides a sheet-like carrier for holding the preparations on at least one of the sides thereof, and a piece of equipment for holding the preparations so as to facilitate the administration of them.

Abstract: An oral formulation for gastrointestinal drug delivery which comprises an adhesion site-controlling layer for attaching the formulation to the selected site in the digestive tract, a drug-carrying layer for containing a drug and an adhesive and a protecting layer for protecting the drug in the drug-carrying layer, wherein the drug-carrying layer exists between the protecting layer and the adhesion site-controlling layer, and the adhesion site-controlling layer may attach to the protecting layer. The formulation can improve bioavailability of drugs which have low bioavailability.

Abstract: The battery assembly system 100 includes a battery assembly including a plurality of storage batteries C1 to Cn connected in series, a voltage detector 3 for detecting respectively voltages generated in the storage batteries, a current detector 4 for detecting a current flowing in the plurality of storage batteries, a state-of-charge (SOC) calculator 2 for calculating the state of charge (SOC) of the storage batteries, respectively, based on the voltages detected respectively by the voltage detectors 3 and the current detected by the current detector 4, and a charging/discharging unit 1 for charging or discharging at least one of the plurality of storage batteries so as to equalize the SOC of the storage batteries calculated respectively by the SOC calculator 2.

Abstract: The battery assembly system 100 includes a battery assembly including a plurality of storage batteries C1 to Cn connected in series, a voltage detector 3 for detecting respectively voltages generated in the storage batteries, a current detector 4 for detecting a current flowing in the plurality of storage batteries, a state-of-charge (SOC) calculator 2 for calculating the state of charge (SOC) of the storage batteries, respectively, based on the voltages detected respectively by the voltage detectors 3 and the current detected by the current detector 4, and a charging/discharging unit 1 for charging or discharging at least one of the plurality of storage batteries so as to equalize the SOC of the storage batteries calculated respectively by the SOC calculator 2.

Abstract: The battery assembly system 100 includes a battery assembly including a plurality of storage batteries C1 to Cn connected in series, a voltage detector 3 for detecting respectively voltages generated in the storage batteries, a current detector 4 for detecting a current flowing in the plurality of storage batteries, a state-of-charge (SOC) calculator 2 for calculating the state of charge (SOC) of the storage batteries, respectively, based on the voltages detected respectively by the voltage detectors 3 and the current detected by the current detector 4, and a charging/discharging unit 1 for charging or discharging at least one of the plurality of storage batteries so as to equalize the SOC of the storage batteries calculated respectively by the SOC calculator 2.

Abstract: By blending glycyrrhizin with an ester mixture comprising a C6-18 fatty acid glycerol ester with a C6-18 fatty acid macrogol ester, glycyrrhizin can be efficiently absorbed via mucosae, in particular, digestive mucosae to achieve a therapeutically effective plasma glycyrrhizin concentration.

Abstract: The purpose of the present invention is to provide micro- or mili-capsules and film preparations having not only sustained-release function but also targeting and adhesive functions with approximately 100% loading efficiency of the objective substance. The present invention provides a parenteral preparation having three layers structure of; basement layer composed of polymer; carrying layer that contains objective substances selected from drugs, aroma chemicals, mosquito propellant, dyes, cells or antigens; and surface layer, and in which the carrying layer is sandwiched between the basement layer and the surface layer.

Abstract: The battery assembly system 100 includes a battery assembly including a plurality of storage batteries C1 to Cn connected in series, a voltage detector 3 for detecting respectively voltages generated in the storage batteries, a current detector 4 for detecting a current flowing in the plurality of storage batteries, a state-of-charge (SOC) calculator 2 for calculating the state of charge (SOC) of the storage batteries, respectively, based on the voltages detected respectively by the voltage detectors 3 and the current detected by the current detector 4, and a charging/discharging unit 1 for charging or discharging at least one of the plurality of storage batteries so as to equalize the SOC of the storage batteries calculated respectively by the SOC calculator 2.

Abstract: The invention provides oral controlled-release preparations suitable to deliver drugs to different sites of gastrointestinal tract and suitable to control the release rate of drugs. As a first function, targeting of drugs to the lower part of the small intestine or colon is possible with two technologies. One is a time-controlled release system comprising adjusting the balance of the tolerability and thickness of a water-insoluble material membrane and the amount of a swellable substance. The other one is an intestinal pressure controlled-release system comprising adjusting the thickness of a water-insoluble material membrane. As a second function, by adjusting pore number, pore size and the amount of gel-forming substance, a sustained-release preparation of extremely water-soluble, hydrophilic, low-molecular weight drug is possible.

Abstract: An enteric formulation for a proteinous drug which protects it from enzymatic degradation and promotes its uptake by the intestinal tract when administered orally, comprises either a solid mass of an intimate mixture of the drug, a nontoxic nonionic surfactant, and an enteric material, or a solid mass of an intimate mixture of the drug with the nonionic surfactant covered by a discrete enteric coating.