Abstract: Citrus amanatsudaidai peel extract, which was used as a starting materials was purified over various kinds of column chromatography (activated carbon, Amberlite IR-120B [H.sup.+ ], cellulose, Sephadex G25 and HPLC) to isolate a peptide as a white powder. This peptide is a water-soluble neutral substance and shows positive reactions to ninhydrin and sodium nitroprusside and negative reactions to anisaldehyde, phenolsulfuric acid and Dragendorff reagent. Amino acids constituting the peptide of the present invention contain aspartic acid and oxylysine in large amounts. Hair growers containing the peptide of the present invention were successful in promoting 150% proliferation of rabbit hair papilla cells when applied in a concentration of 1.4 .mu.g/ml.

Abstract: Bioactive substances K93-0711 I-1 and I-2 having inhibitory action on IL-6 activity, are produced by culturing a microorganism belonging to the genus Streptomyces in a medium, whereby the bioactive substances K93-0711 I-1 and I-2 accumulate in the medium. These bioactive substances K93-0711 I-1 and I-2 are then isolated therefrom. The substances are effective for treatment of IL-6-involving diseases such as cancer cachexia, multiple myeloma and rheumatoid arthritis.

Abstract: Antibiotic 82-85-8A, or a pharmacologically acceptable non-toxic salt thereof, having the following physicochemical properties:(1) Elementary analysis: C.sub.31 H.sub.47 N.sub.8 O.sub.10 Cl (determined by high resolution mass spectrometry)(2) Molecular weight: 726.5 (determined by field desorption mass spectrometry and calculated from elementary analysis)(3) Melting point: 162.degree.-167.degree. C. (partially immersed at 160.degree. C., completely melted at 167.degree. C., no browning)(4) Specific rotation: [.alpha.].sub.D.sup.20 =-56.degree. (c=0.24, methanol)(5) Ultraviolet absorption spectrum (in methanol): shown in FIG. 1(6) Infrared absorption spectrum (KBr): shown in FIG. 2(7) Solubility:soluble: chloroform, dichloromethane, ethyl acetate, methanol, ethanol,slightly soluble: acetone,insoluble: hexane, water;(8) Color reaction:Positive: iodine, sulfuric acid, Dragendorf reactionNegative: ninhydrin, ferric chloride(9) Nature: weakly basic substance.

Abstract: A novel antibiotic, awamycin, and its production. Awamycin is active against gram positive bacteria and exhibits growth inhibitory activity against Erhlich ascites and Sarcoma 180 cells. Some of the identifying characteristics of awamycin include a molecular weight of 744.+-.1 (mass spectrum analysis), an elementary analysis of 59.16% C, 6.48% H and 1.88% N; a melting point of 158.degree. C.; an optical rotation of [.alpha.].sub.D 24=+836.degree.. Awamycin is an acidic substance, which provides an orange colored powder, and is poorly soluble in water.

Abstract: Antibiotic 81-484 of the following physico-chemical properties:(1) elementary analysis: C.sub.33 H.sub.48 O.sub.7 (high resolution mass spectrum);(2) molecular weight: 556 [Field desorption (FD) mass spectrum];(3) melting point: not clear (oily at 10.degree.-100.degree. C.);(4) specific rotation: [.alpha.].sub.D.sup.20 =-151.degree. (c=0.1, methanol);(5) ultraviolet absorption spectrum: shown in FIG. 1 (in methanol);(6) infrared absorption spectrum: shown in FIG. 2 (KBr tablet);(7) solubility: insoluble in hexane and water, soluble in diethyl ether, methanol, ethanol, dichloromethane, chloroform, ethyl acetate, butyl acetate, acetone and benzene;(8) nuclear magnetic resonance spectrum: shown in FIG. 3 (CDCl.sub.3, TMS);(9) nature: acidic substance;(10) color reaction:negative for ninhydrin, anthrone-H.sub.2 SO.sub.

Abstract: A new acidic polysaccharide is isolated from a culture of cells of the algae Chlorella pyrenoidosa. The process for producing this polysaccharide is also disclosed. This substance exhibits antitumor activity and antiviral activity and induces the production of interferon.

Abstract: A novel proteinous substance KUP-PC, which is produced by culturing proteinous substance KUD-PC producing organisms belonging to the genus Streptosporangium. KUD-PC increases the antitumor activity of the anti-tumor substance, sporamycin.

Abstract: This invention relates to the antibiotic stubomycin and process for producing same by culturing streptomyces sp KG - 2245 FERM-P No.

Abstract: A novel antibiotic sporamycin has both anti-transplanted tumor and antibacterial activity and is produced by culturing a microorganism of the genus Streptosporangium, particularly Streptosporangium pseudovulgare PO-357 FERM-P No. 3571, ATCC No. 31308.

Abstract: The present invention relates to a new antibiotic designated as OS-3256-B. OS-3256-B exhibits excellent inhibitory activities against animal tumors such as leukemia L-1210, Sarcoma-180 and Hela cells and gram-positive bacteria and is classified into the diazocompounds group. However, chromatographic analysis, Rf value and other experimental data reveal that OS-3256-B is a new compound of the type of azaamino acid derivatives. The present invention also provides a process for producing OS-3256-B by fermentation, in which OS-3256-B is produced by culturing a microorganism belonging to Streptomyces candidus var. azaticus in a culture medium conventionally used for culturing Streptomyces strain microorganisms.