Abstract: This invention relates to a novel class of acidic amino acid/dicarboxylic acid derivatives (sulfonic acid/sulfate derivatives of naturally occurring amino acids and their amides) useful as inhibitors of osteoclastogenesis. The invention also provides methods of using the novel class of acidic amino acid/dicarboxylic acid derivatives of the general formula ZOC—(CRR)m—COOH, wherein: m=2, 3 or 4; Z is OH or NH2; one R in the compound is from the group consisting of SO3H, OSO3H, CH2—SO3H, CH2—OSO3H, and NHSO3H, and the remaining Rs are H or NH2, for inhibition of osteoclastogenesis.

Abstract: The present invention is related to compounds having general formula Z-OC (CRn1Rn2)—CO-Z wherein Z=OH or NH2 and n1=n2=1 to 8, useful for modulation of immune response by inducing differentiation of dendritic cells consisting novel class of amino acid derivatives (sulfonic acid/sulfate derivatives of naturally occurring amino acids, and their amides) of the general formula ZOC—CR3R4—CR2(NHR1)—COOH, ZOC—CR5R6—CR3R4—CR1(NHR2)—COOH, ZOC—CR7R8—CR5R6—CR3R4—CR1N2)—COOH wherein Z=OH or NH2; R1 to R8 denotes H, SO3H, or OSO3H. In addition, the dicarboxylic acids and their amides ZOC—(CH2)n—CR1R2—COOH, where Z=OH or NH2; and n=1, 2, 3. The groups R1/R2=H/SO3H or OSO3H or CH2—SO3H or CH2—OSO3H and vice versa. The factors also contain different divalent metal cations such as Mg, Ca and Zn.