Abstract: A bispecific antibody including a first domain which specifically binds to a mutant calreticulin protein and a second domain which specifically binds to a CD3 antigen. A pharmaceutical composition including the bispecific antibody or a functional fragment thereof. A diagnostic method for a myeloproliferative neoplasm, including detecting a polypeptide in a biological sample with the bispecific antibody.

Abstract: A film-forming composition for skin, including components (A) and (B): (A) a powder, and (B) a fiber having an average fiber diameter of 0.1 ?m or more and 7 ?m or less and an aspect ratio (average fiber length/average fiber diameter) of 20 or more and 300 or less in an amount of 0.1 mass % or more and 10 mass % or less relative to the whole film-forming composition. A mass ratio of the component (B) to the component (A), (B/A), is 0.02 or more and 0.4 or less.

Abstract: A film-forming composition for skin, including components (A) and (B): (A) a silicone-based film-forming agent; and (B) a fiber having an average fiber diameter of 0.1 ?m or more and 7 ?m or less in an amount of 0.05 mass % or more and 2 mass % or less relative to the whole film-forming composition. A mass ratio of the component (B) to the component (A), (B/A), is 0.05 or more and 1 or less.

Abstract: A method for forming a coating on a skin surface using a nanofiber sheet, the method including: (1) applying to the skin a sheet transparentizing agent containing 2 mass % or more of one or more oil agent; and (2) transferring a white nanofiber sheet mainly composed of a water-insoluble polymer to the skin after (1), where the transferred white nanofiber sheet becomes transparent and the coating is a transparent coating through which the skin is visible.

Abstract: Provided is a composition containing fine fibers for forming a coating film. The composition has excellent spreadability and provides a coating film with excellent uniformity by application to a skin. A composition for forming a coating film comprising the following components (a) and (b): (a) a fiber at 0.5 mass % or more and 10 mass % or less based on the total composition for forming a coating film. The fiber has an average fiber diameter of 0.1 ?m or more and 7 ?m or less and an aspect ratio [(average fiber length)/(average fiber diameter)] of 8 or more and 300 or less; and (b) a volatile component at 15 mass % or more and 90 mass % or less based on the total composition for forming a coating film. The [(average fiber diameter)2/(fiber content)] (?m2/mass %) of the composition is 0.005 or more and 7 or less, and the total content of the component (a) and the component (b) is 97 mass % or less.

Abstract: Provided is a composition for forming a coating film containing fine fibers, imparting an excellent durability to an obtained coating film. A composition for forming a coating film comprises the following components (a) and (b): (a) one or more oil agents selected from the group consisting of ester oil, ether oil, hydrocarbon oil and higher alcohol; and (b) a fiber, at 0.5 mass or more and 10 mass % or less based on the total composition for forming a coating film, the fiber having an average fiber diameter of 0.1 ?m or more and 7 ?m or less. [(average fiber diameter)2/(fiber content)] (?m2/mass %) in the composition is 0.005 or more and 7 or less, and the mass ratio of the component (b) to the component (a), (b/a), is 0.005 or more and 5 or less.

Abstract: To provide a method for forming a transparent coating that is highly adherent to the skin and through which the skin is visible. A method for forming a coating on a skin surface using a nanofiber sheet, the method comprising: (1) Step (1) of applying to the skin a sheet transparentizing agent comprising 2 mass or more of one or more oil agents; and (2) Step (2) of transferring a white nanofiber sheet mainly composed of a water-insoluble polymer to the skin after Step (1).