Abstract: According to one embodiment, a platooning operation system organizes a platoon by making a plurality of vehicles cooperate. The platooning operation system includes an application acceptance processor and a platoon organization processor. The application acceptance processor accepts an application of a vehicle for admission to the platoon. The platoon organization processor which selects a platoon to which the vehicle is to be admitted or determines possibility of admission of the vehicle to the platoon, based on at least one of information on a driver driving the vehicle and information on the vehicle.

Abstract: A straddled vehicle, including a cross member connecting right and left seat frames, a seat above the cross member and right and left seat frames, left and right side covers, a rear fender, an intake passage formed below the seat, between the left and right side covers and above the rear fender, an air cleaner located in a front part of the intake passage, left and right inlet ports located in a rear part of the intake passage, first and second fastening portions respectively fastening the right and left side cover to the right and left seat frames or to the rear fender. In a rear view of the vehicle, the cross member is convex upward and does not overlap the right or left inlet port, and the first and second fastening portions are located outside the intake passage, or are located inside the intake passage but does not overlap the right or left inlet port.

Abstract: A straddled vehicle, including a cross member connecting right and left seat frames, a seat above the cross member and right and left seat frames, left and right side covers, a rear fender, an intake passage formed below the seat, between the left and right side covers and above the rear fender, an air cleaner located in a front part of the intake passage, left and right inlet ports located in a rear part of the intake passage, first and second fastening portions respectively fastening the right and left side cover to the right and left seat frames or to the rear fender. In a rear view of the vehicle, the cross member is convex upward and does not overlap the right or left inlet port, and the first and second fastening portions are located outside the intake passage, or are located inside the intake passage but does not overlap the right or left inlet port.

Abstract: On the basis of a cathepsin S inhibitory effect, an excellent agent for treating or preventing autoimmune disease, allergic disease, graft rejection of an organ, bone marrow or tissue, systemic lupus erythematosus, or the like is provided. It was found that a nitrogen-containing bicyclic heterocyclic compound has an excellent cathepsin S inhibitory effect, thereby completing the invention. The compound of the present invention has an cathepsin S inhibitory effect, and can be used as an agent for preventing and/or treating autoimmune disease, allergic disease, graft rejection of an organ, bone marrow or tissue, systemic lupus erythematosus, or the like.

Abstract: On the basis of a cathepsin S inhibitory effect, an excellent agent for treating or preventing autoimmune disease, allergic disease, graft rejection of an organ, bone marrow or tissue, systemic lupus erythematosus, or the like is provided. It was found that a nitrogen-containing bicyclic heterocyclic compound has an excellent cathepsin S inhibitory effect, thereby completing the invention. The compound of the present invention has an cathepsin S inhibitory effect, and can be used as an agent for preventing and/or treating autoimmune disease, allergic disease, graft rejection of an organ, bone marrow or tissue, systemic lupus erythematosus, or the like.

Abstract: [Problem] On the basis of a cathepsin S inhibitory effect, an excellent agent for treating or preventing autoimmune disease, allergic disease, graft rejection of an organ, bone marrow or tissue, systemic lupus erythematosus, or the like is provided. [Means for Solution] It was found that a nitrogen-containing bicyclic heterocyclic compound has the excellent cathepsin S inhibitory effect, thereby completing the invention. The compound of the present invention has the cathepsin S inhibitory effect, and can be used as an agent for preventing and/or treating autoimmune disease, allergic disease, graft rejection of an organ, bone marrow or tissue, systemic lupus erythematosus, or the like.

Abstract: [Problem] On the basis of a cathepsin S inhibitory effect, an excellent agent for treating or preventing autoimmune disease, allergic disease, graft rejection of an organ, bone marrow or tissue, systemic lupus erythematosus, or the like is provided. [Means for Solution] It was found that a nitrogen-containing bicyclic heterocyclic compound has the excellent cathepsin S inhibitory effect, thereby completing the invention. The compound of the present invention has the cathepsin S inhibitory effect, and can be used as an agent for preventing and/or treating autoimmune disease, allergic disease, graft rejection of an organ, bone marrow or tissue, systemic lupus erythematosus, or the like.