Publication number: 20240287079
Abstract: A 6-aminopyrazolopyrimidine compound, or a pharmaceutically acceptable salt thereof, having NLRP3 inflammasome inhibitory activity, a pharmaceutical composition comprising the same, and their medical use, etc., are provided. A compound of Formula [IA]: or a pharmaceutically acceptable salt thereof, wherein a partial structure: is a structure of the following formula: etc. wherein R4 is hydrogen or C1-4 alkyl, in which the alkyl may be optionally substituted with hydroxy or cyano, Ring group CyA is a group of the following formula: etc. wherein R6 and R7 are, each independently, hydrogen, hydroxy, cyano, C1-6 alkyl, etc., R8 and R9 are, each independently, hydrogen, C1-4 alkyl, or C1-4 haloalkyl, R10 is hydrogen, cyano, C1-6 alkyl, etc.), R1 is hydrogen or C1-4 alkyl, R2A and R3A are, each independently, hydrogen, C1-6 alkyl etc.
Type:
Application
Filed:
August 30, 2022
Publication date:
August 29, 2024
Inventors:
Yusuke Ohba, Kaoru Adachi, Tatsuya Nishimaru, Kentaro Sakurai, Yosuke Ogoshi, Shimpei Sato