Patents by Inventor Kaoru Hazeki

Kaoru Hazeki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Screening method for a substance that binds to an intracellular region of TLR4
    Patent number: 8329420
    Abstract: The present invention provides a method of screening for a drug for the prophylaxis or treatment of at least one disease selected from the group consisting of cardiac disease, autoimmune disease, inflammatory disease, central nervous system disease, infectious disease, sepsis, severe sepsis and septic shock, which includes selecting a substance that binds to an intracellular region of TLR4, and inhibits signal transduction from said molecule, and a kit for this method, which contains (1) a cell that expresses wild-type TLR4 and (2) a cell that expresses a mutant TLR4, and which can detect a signal from TLR4 with expression of a reporter gene as an index.
    Type: Grant
    Filed: March 29, 2007
    Date of Patent: December 11, 2012
    Assignees: Hiroshima University, Takeda Pharmaceutical Company Limited
    Inventors: Osamu Hazeki, Kaoru Hazeki, Masayuki Ii, Naoko Matsunaga
  • Screening Method
    Publication number: 20090317833
    Abstract: The present invention provides a method of screening for a drug for the prophylaxis or treatment of at least one disease selected from the group consisting of cardiac disease, autoimmune disease, inflammatory disease, central nervous system disease, infectious disease, sepsis, severe sepsis and septic shock, which includes selecting a substance that binds to an intracellular region of TLR4, and inhibits signal transduction from said molecule, and a kit for this method, which contains (1) a cell that expresses wild-type TLR4 and (2) a cell that expresses a mutant TLR4, and which can detect a signal from TLR4 with expression of a reporter gene as an index.
    Type: Application
    Filed: March 29, 2007
    Publication date: December 24, 2009
    Inventors: Osamu Hazeki, Kaoru Hazeki, Masayuki Ii, Naoko Matsunaga