Patents by Inventor Kaoru OKAMURA
Kaoru OKAMURA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11919987Abstract: The present invention provides a (meth)acryloyl compound suitable to prepare a medical material having beneficial hydrophilicity and sufficient strength; and a method for preparing the compound. A compound represented by the following formula (1): wherein R1 is a hydrogen atom or a methyl group, R2 is a monovalent hydrocarbon group having 1 to 6 carbon atoms, R3 is a hydrogen atom or a methyl group and, L is a divalent hydrocarbon group having 2 to 10 carbon atoms and optionally having an ether bond.Type: GrantFiled: August 22, 2019Date of Patent: March 5, 2024Assignee: Shin-Etsu Chemical Co., Ltd.Inventor: Kaoru Okamura
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Patent number: 11859055Abstract: The purpose of the present invention is to provide a polysiloxane monomer which gives an ophthalmic device with excellent wettability and a method for preparing the same. The present invention provides a compound represented by the following formula (1): wherein R1 is a hydrogen atom or a methyl group, L1 is a single bond or a divalent hydrocarbon group which has 1 to 6 carbon atoms and may have at least one selected from an ether bond, an ester bond, and a urethane bond, Z is a monovalent organic group which has 1 to 10 carbon atoms and has a quaternary ammonium group or an amphoteric ion group, A is a linear or branched organo(poly)siloxanyl group having 1 to 100 siloxane units, L2 is a linear, branched or cyclic, divalent or trivalent hydrocarbon group which has 2 to 10 carbon atoms and may have an ether bond, and L3 is a divalent or trivalent hydrocarbon group having one carbon atom, provided that and when L3 is trivalent, then L2 is also trivalent, and L3 and L2 together form a ring.Type: GrantFiled: May 31, 2019Date of Patent: January 2, 2024Assignee: Shin-Etsu Chemical Co., Ltd.Inventor: Kaoru Okamura
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Publication number: 20220332863Abstract: A purpose of the present invention is to provide a siloxane suitable for preparing a medical material and a method for preparing the compound. The present invention provides a siloxane represented by the formula (1), wherein R1 is a hydrogen atom or a methyl group, R2 is a monovalent hydrocarbon group having 1 to 6 carbon atoms, L is a divalent hydrocarbon group which has 2 to 10 carbon atoms and may have one or more ether bonds, and A is a (poly)siloxane group represented by the formula (2) or (3), wherein n is an integer of 1 to 100, a is an integer of 0 to 10, b is an integer of 0 to 10, and c is an integer of 0 to 10, provided that a+b+c is 2 or more, and R is, independently of each other, a monovalent hydrocarbon group having 1 to 10 carbon atoms. The present invention further provides a method for preparing the siloxane, a polymer comprising recurring units derived from the siloxane, and a medical material, particularly an ophthalmic device, comprising the aforesaid polymer.Type: ApplicationFiled: May 26, 2020Publication date: October 20, 2022Inventor: Kaoru Okamura
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Patent number: 11180614Abstract: A compound represented by the formula (1) is described, which has a linear polysiloxane structure at the end, a polymerizable group at the other end, and a polyether group or a hydrophilic group as a side chain bounded to a linking group which is represented by -(L1)a-CH-L2- in the formula (1) and exists between the polysiloxane structure and the terminal polymerizable group. The compound has excellent compatibility with a hydrophilic monomer, and the surface wettability of hydrogel obtained from the compound as a monomer is improved. Methods are also described for preparing the polysiloxane monomer compound, a polymer having a repeating unit derived from the polymerization at the (meth)acryl group of the polysiloxane monomer compound, and an ophthalmic device containing the polymer.Type: GrantFiled: March 30, 2018Date of Patent: November 23, 2021Assignee: SHIN-ETSU CHEMICAL CO., LTD.Inventor: Kaoru Okamura
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Publication number: 20210324123Abstract: The present invention provides a (meth)acryloyl compound suitable to prepare a medical material having beneficial hydrophilicity and sufficient strength; and a method for preparing the compound. A compound represented by the following formula (1): wherein R1 is a hydrogen atom or a methyl group, R2 is a monovalent hydrocarbon group having 1 to 6 carbon atoms, R3 is a hydrogen atom or a methyl group and, L is a divalent hydrocarbon group having 2 to 10 carbon atoms and optionally having an ether bond.Type: ApplicationFiled: August 22, 2019Publication date: October 21, 2021Inventor: Kaoru Okamura
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Publication number: 20210238363Abstract: The purpose of the present invention is to provide a polysiloxane monomer which gives an ophthalmic device with excellent wettability and a method for preparing the same. The present invention provides a compound represented by the following formula (1): wherein R1 is a hydrogen atom or a methyl group, L1 is a single bond or a divalent hydrocarbon group which has 1 to 6 carbon atoms and may have at least one selected from an ether bond, an ester bond, and a urethane bond, Z is a monovalent organic group which has 1 to 10 carbon atoms and has a quaternary ammonium group or an amphoteric ion group, A is a linear or branched organo(poly)siloxanyl group having 1 to 100 siloxane units, L2 is a linear, branched or cyclic, divalent or trivalent hydrocarbon group which has 2 to 10 carbon atoms and may have an ether bond, and L3 is a divalent or trivalent hydrocarbon group having one carbon atom, provided that and when L3 is trivalent, then L2 is also trivalent, and L3 and L2 together form a ring.Type: ApplicationFiled: May 31, 2019Publication date: August 5, 2021Inventor: Kaoru Okamura
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Publication number: 20210122769Abstract: An object of the present invention is to provide a monomer having a polysiloxane structure and capable of providing a polymer having sufficient compatibility and hydrolysis resistance while having high oxygen permeability useful for an ophthalmic device, and a method for producing the monomer. The present invention provides a compound represented by the formula (1) which has a radical-polymerizable group at one terminal, one to three alkylsiloxy groups having a hydrophilic and bulky group represented by formula (3-A) or formula (3-B), and has a divalent hydrocarbon group L which has 2 to 20 carbon atoms and may contain one or more selected from an ether bond and a urethane bond, a part of hydrogen atoms bonded to the carbon atoms may be substituted with a hydroxyl group.Type: ApplicationFiled: July 20, 2018Publication date: April 29, 2021Applicant: SHIN-ETSU CHEMICAL CO., LTD.Inventor: Kaoru OKAMURA
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Patent number: 10920075Abstract: A polymerizable monomer compound is disclosed, which can produce a polymer having advantageous transparency and high oxygen permeability for use as an ophthalmic device, while exhibiting sufficient resistance to hydrolysis. A silicone compound of the following formula (1) is described: where the residue R1R2R3Si— has a steric parameter value of ?1.00 or less, the parameter indicating the steric bulkiness of the unsubstituted hydrocarbon groups bonded to the silicon atom, and in a case where at least one of R1, R2 and R3 is a substituted hydrocarbon group, the steric parameter value of the residue in which each of the functional group and halogen atom bonded to the carbon atom of the substituted hydrocarbon group is supposed to be substituted with a hydrogen atom is ?1.00 or less. Methods for producing the monomer compound, and methods for preparing the silicone compound are also described.Type: GrantFiled: April 17, 2017Date of Patent: February 16, 2021Assignee: SHIN-ETSU CHEMICAL CO., LTD.Inventor: Kaoru Okamura
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Publication number: 20200362067Abstract: Provided is a highly pure siloxane compound having a glycerol (meth)acrylate, wherein the siloxane compound is obtained by subjecting a carboxylic acid and an epoxy-modified siloxane compound having a bulky substituent on silicon atoms in a polysiloxane to an addition reaction to suppress side reactions derived from generated hydroxyl groups or side reactions between the carboxylic acid and the siloxane moiety. Furthermore, a siloxane compound containing a bulky substituent group-terminated glycerol (meth)acrylate is used as a monomer to thereby provide a copolymer which has excellent solubility in solvents such as acetone compared to (co)polymers obtained using SiGMA as a monomer.Type: ApplicationFiled: November 9, 2018Publication date: November 19, 2020Applicant: Shin-Etsu Chemical Co., Ltd.Inventor: Kaoru OKAMURA
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Publication number: 20200231608Abstract: An object of the present invention is to provide a monomer having a polysiloxane structure and capable of providing a polymer having sufficient compatibility and hydrolysis resistance while having high oxygen permeability useful for an ophthalmic device, and a method for producing the monomer. The present invention provides a siloxane compound represented by the formula (1) which has a radical-polymerizable group at one terminal and an alkyl group having 1 to 10 carbon atoms at the other terminal, and has a divalent hydrocarbon group L which has 2 to 20 carbon atoms and may contain one or more selected from an ether bond and a urethane bond, wherein a part of hydrogen atoms bonded to the carbon atoms may be substituted with a hydroxyl group. The siloxane compound further has a hydrophilic group represented by formula (3) bonded to a silicon atom in the siloxane chain.Type: ApplicationFiled: July 20, 2018Publication date: July 23, 2020Applicant: SHIN-ETSU CHEMICAL CO., LTD.Inventor: Kaoru OKAMURA
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Publication number: 20200148831Abstract: [Problems to be Solved] The present invention provides a polysiloxane monomer which gives an ophthalmic device with excellent wettability and a method for preparing the same. [Means to Solve the Problems] The present invention provides a compound represented by the formula (1) which has a linear polysiloxane structure at the end, a polymerizable group at the other end, and a polyether group or a hydrophilic group as a side chain bounded to a linking group which is represented by -(L1)a-CH-L2- in the formula (1) and exists between the polysiloxane structure and the terminal polymerizable group. The compound has excellent compatibility with a hydrophilic monomer, and the surface wettability of hydrogel obtained from the compound as a monomer is improved.Type: ApplicationFiled: March 30, 2018Publication date: May 14, 2020Applicant: SHIN-ETSU CHEMICAL CO., LTD.Inventor: Kaoru OKAMURA
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Publication number: 20190136059Abstract: One object of the invention is to provide a polymerizable monomer compound having a predetermined number of silicon atoms, which can give a polymer having advantageous transparency and high oxygen permeability for use as an ophthalmic device, while exhibiting sufficient resistance to hydrolysis. Another object of the invention is to provide a method for producing such a monomer compound.Type: ApplicationFiled: April 17, 2017Publication date: May 9, 2019Applicant: SHIN-ETSU CHEMICAL CO., LTD.Inventor: Kaoru OKAMURA
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Publication number: 20180362716Abstract: [Problem] The present invention aims to prove an organopolysiloxane compound that has different functional groups at terminals of the polysiloxane and that has a sufficient siloxane content, and a method for producing the same. The present invention also provides a polysiloxane compound having a terminal amino group and another terminal functional group, and a method for producing the same. [Solution] The present invention provides a silicone compound represented by general formula (I) and having different functional groups at terminals. The silicone compound has, at one terminal of the diorganopolysiloxane (i.e., A-terminus in general formula (I)), a functional group that is unreactive with an organometallic compound, a functional group that is radically polymerizable or a functional group that is reactive with an organometallic compound (a first organic functional group) or an atom, and, at the other terminal (i.e.Type: ApplicationFiled: October 21, 2016Publication date: December 20, 2018Applicant: SHIN-ETSU CHEMICAL CO., LTD.Inventor: Kaoru OKAMURA