Patents by Inventor Kaoru Takegawa

Kaoru Takegawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Host, transformant and method for producing the transformant and method for producing O-glycosylated heterologous protein
    Patent number: 8663948
    Abstract: The object is to provide a transformant which can produce a heterologous protein having a structurally controlled O-linked sugar chain having an O-Man-Gal disaccharide structure, a method for producing the transformant by using Schizosaccharomyces pombe as the host, and provide a host for producing the transformant and a method for producing an O-glycosylated heterologous protein. An Schizosaccharomyces pombe host having no omh1 gene or an inactivated omh1 gene in its chromosomes for producing an O-glycosylated heterologous protein having an O-linked sugar chain having an O-Man-Gal disaccharide structure by expression of the heterologous protein by a genetic engineering technique and subsequent glycosylation of the expressed heterologous protein. A transformant from the host, a method for producing the transformant and a method for producing an O-glycosylated heterologous protein by using the transformant.
    Type: Grant
    Filed: March 31, 2011
    Date of Patent: March 4, 2014
    Assignee: Asahi Glass Company, Limited
    Inventors: Kaoru Takegawa, Hideki Tohda, Chihiro Hama
  • Host, transformant and method for producing the transformant and method for producing O-glycosylated heterologous protein
    Patent number: 8318454
    Abstract: The object is to provide a transformant which can produce a heterologous protein having a structurally controlled O-linked sugar chain having an O-Man-Gal disaccharide structure, a method for producing the transformant by using Schizosaccharomyces pombe as the host, and provide a host for producing the transformant and a method for producing an O-glycosylated heterologous protein. An Schizosaccharomyces pombe host having no omh1 gene or an inactivated omh1 gene in its chromosomes for producing an O-glycosylated heterologous protein having an O-linked sugar chain having an O-Man-Gal disaccharide structure by expression of the heterologous protein by a genetic engineering technique and subsequent glycosylation of the expressed heterologous protein. A transformant from the host, a method for producing the transformant and a method for producing an O-glycosylated heterologous protein by using the transformant.
    Type: Grant
    Filed: March 31, 2011
    Date of Patent: November 27, 2012
    Assignee: Asahi Glass Company, Limited
    Inventors: Kaoru Takegawa, Yuko Hama, Chihiro Hama, legal representative, Hideki Tohda
  • HOST, TRANSFORMANT AND METHOD FOR PRODUCING THE TRANSFORMANT AND METHOD FOR PRODUCING O-GLYCOSYLATED HETEROLOGOUS PROTEIN
    Publication number: 20110287481
    Abstract: The object is to provide a transformant which can produce a heterologous protein having a structurally controlled O-linked sugar chain having an O-Man-Gal disaccharide structure, a method for producing the transformant by using Schizosaccharomyces pombe as the host, and provide a host for producing the transformant and a method for producing an O-glycosylated heterologous protein. An Schizosaccharomyces pombe host having no omh1 gene or an inactivated omh1 gene in its chromosomes for producing an O-glycosylated heterologous protein having an O-linked sugar chain having an O-Man-Gal disaccharide structure by expression of the heterologous protein by a genetic engineering technique and subsequent glycosylation of the expressed heterologous protein. A transformant from the host, a method for producing the transformant and a method for producing an O-glycosylated heterologous protein by using the transformant.
    Type: Application
    Filed: March 31, 2011
    Publication date: November 24, 2011
    Applicant: ASAHI GLASS COMPANY, LIMITED
    Inventors: Kaoru TAKEGAWA, Yuko Hama, Chihiro Hama, Hideki Tohda
  • Gene encoding endo-.beta.-N-acetylglucosaminidase A
    Patent number: 5985637
    Abstract: An isolated DNA having a sequence encoding a polypeptide possessing endo-.beta.-N-acetylglucosaminidase A activity or functionally equivalent variants thereof; and a method for producing a polypeptide possessing endo-.beta.-N-acetylglucosaminidase A activity or functionally equivalent variants thereof using the isolated DNA by recombinant DNA technology.
    Type: Grant
    Filed: November 19, 1997
    Date of Patent: November 16, 1999
    Assignee: Takara Shuzo Co., Ltd.
    Inventors: Kaoru Takegawa, Shojiro Iwahara
  • Process for producing carbohydrate or glycoconjugate
    Patent number: 5955324
    Abstract: To provide a process for producing a carbohydrate or a glycoconjugate without forming any hydrolytic product of the remodeled sugar chain.A process for producing a carbohydrate or a glycoconjugate by a remodeling reaction in the presence of a glycosidase which performs the remodeling reaction in an aqueous medium containing a water-soluble ketone and/or dioxane. Examples of the glycosidase include endoglycosidases such as Endo-A. Examples of the ketone include acetone.
    Type: Grant
    Filed: August 19, 1997
    Date of Patent: September 21, 1999
    Assignee: Takara Shuzo Co., Ltd.
    Inventors: Jian Qiang Fan, Yuan Chuan Lee, Kaoru Takegawa, Shojiro Iwahara, Akihiro Kondo, Ikunoshin Kato