Patents by Inventor Kaptan Singh

Kaptan Singh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of baricitinib and an intermediate thereof
    Patent number: 10526350
    Abstract: The present invention provides processes for the preparation of baricitinib of Formula I and an intermediate of Formula V. The present invention also provides the use of the intermediate of Formula V for the preparation of baricitinib.
    Type: Grant
    Filed: February 2, 2016
    Date of Patent: January 7, 2020
    Assignee: Sun Pharmaceutical Industries Limited
    Inventors: Md Abul Kalam Azad, Gyanendra Pandey, Kaptan Singh, Mohan Prasad
  • PROCESS FOR THE PREPARATION OF BARICITINIB AND AN INTERMEDIATE THEREOF
    Publication number: 20190100538
    Abstract: The present invention provides processes for the preparation of baricitinib of Formula I and an intermediate of Formula V. The present invention also provides the use of the intermediate of Formula V for the preparation of baricitinib.
    Type: Application
    Filed: February 2, 2016
    Publication date: April 4, 2019
    Inventors: Md Abul Kalam AZAD, Gyanendra PANDEY, Kaptan SINGH, Mohan PRASAD
  • Crystalline form of afatinib dimaleate
    Patent number: 10011591
    Abstract: The present invention provides a crystalline Form I of afatinib dimaleate, its process for preparation and pharmaceutical composition thereof, and its use in the treatment of metastatic non-small cell lung cancer.
    Type: Grant
    Filed: October 1, 2015
    Date of Patent: July 3, 2018
    Assignee: Sun Pharmaceutical Industries Limited
    Inventors: Shravan Kumar Singh, Shyam Sunder Verma, Kaptan Singh, Mohan Prasad
  • Crystalline form of baricitinib
    Patent number: 9938283
    Abstract: The present invention provides a crystalline form of baricitinib characterized by an XRPD pattern substantially as depicted in FIG. 1, a process for its preparation, a pharmaceutical composition comprising it, and its use for the treatment of JAK-associated diseases.
    Type: Grant
    Filed: April 29, 2015
    Date of Patent: April 10, 2018
    Assignee: Sun Pharmaceutical Industries Limited
    Inventors: Gyanendra Pandey, Javeena, Kaptan Singh, Mohan Prasad
  • Process for the preparation of baricitinib and an intermediate thereof
    Patent number: 9873706
    Abstract: The present invention provides a process for the preparation of baricitinib and an intermediate thereof. The present invention provides a convenient, economical, and industrially advantageous two-step process for the preparation of [4-(IH-pyrazol-4-yl)-7Hpyrrolo[2,3-d] pyrimidin-7-yl]methyl pivalate of Formula (II). The process of the present invention involves the use of an alkali or alkaline earth metal hydroxide, carbonate, or bicarbonate as a base for reacting 4-chloro-7H-pyrrolo[2,3-d]pyrimidine of Formula (III) with chloromethyl pivalate of Formula (IV), and the use of an unprotected pyrazole borolane of Formula (VIII) for the conversion of (4-chloro-7H-pyrrolo[2,3-d] pyrimidin-7-yl)methyl 2,2-dimethylpropanoate of Formula V into [4-(1H-pyrazol-4-yl)-7Hpyrrolo[2,3-d]pyrimidin-7-yl]methyl pivalate of Formula (II). The process of the present invention provides [4-(1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]methyl pivalate of Formula (I) in high yield.
    Type: Grant
    Filed: December 4, 2015
    Date of Patent: January 23, 2018
    Assignee: Sun Pharmaceutical Industries Limited
    Inventors: Md Abul Kalam Azad, Gyanendra Pandey, Kaptan Singh, Mohan Prasad
  • PROCESS FOR THE PREPARATION OF BARICITINIB AND AN INTERMEDIATE THEREOF
    Publication number: 20170327507
    Abstract: The present invention provides a process for the preparation of baricitinib and an intermediate thereof. The present invention provides a convenient, economical, and industrially advantageous two-step process for the preparation of [4-(IH-pyrazol-4-yl)-7Hpyrrolo[2,3-d] pyrimidin-7-yl]methyl pivalate of Formula (II). The process of the present invention involves the use of an alkali or alkaline earth metal hydroxide, carbonate, or bicarbonate as a base for reacting 4-chloro-7H-pyrrolo[2,3-d]pyrimidine of Formula (III) with chloromethyl pivalate of Formula (IV), and the use of an unprotected pyrazole borolane of Formula (VIII) for the conversion of (4-chloro-7H-pyrrolo[2,3-d] pynmidin-7-yl)methyl 2,2-dimethylpropanoate of Formula V into [4-(1H-pyrazol-4-yl)-7Hpyrrolo[2,3-d]pyrimidin-7-yl]methyl pivalate of Formula (II). The process of the present invention provides [4-(1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]methyl pivalate of Formula (I) in high yield.
    Type: Application
    Filed: December 4, 2015
    Publication date: November 16, 2017
    Inventors: Md Abul Kalam AZAD, Gyanendra PANDEY, Kaptan SINGH, Mohan PRASAD
  • Process for the preparation of 4-dimethylaminocrotonic acid
    Patent number: 9758471
    Abstract: The present invention provides a process for the preparation of 4-dimethylaminocrotonic acid of Formula (II) or its salts, which is used as an intermediate for the preparation of afatinib or its salts.
    Type: Grant
    Filed: June 2, 2015
    Date of Patent: September 12, 2017
    Assignee: Sun Pharmaceutical Industries Limited
    Inventors: Shyam Sunder Verma, Shravan Kumar Singh, Kaptan Singh, Mohan Prasad
  • CRYSTALLINE FORM OF AFATINIB DIMALEATE
    Publication number: 20170240533
    Abstract: The present invention provides a crystalline Form I of afatinib dimaleate, its process for preparation and pharmaceutical composition thereof, and its use in the treatment of metastatic non-small cell lung cancer.
    Type: Application
    Filed: October 1, 2015
    Publication date: August 24, 2017
    Applicant: Sun Pharmaceutical Industries Limited
    Inventors: Shravan Kumar SINGH, Shyam Sunder VERMA, Kaptan SINGH, Mohan PRASAD
  • CRYSTALLINE FORM OF BARICITINIB
    Publication number: 20170204097
    Abstract: The present invention provides a crystalline form of baricitinib characterized by an XRPD pattern substantially as depicted in FIG. 1, a process for its preparation, a pharmaceutical composition comprising it, and its use for the treatment of JAK-associated diseases.
    Type: Application
    Filed: April 29, 2015
    Publication date: July 20, 2017
    Inventors: Gyanendra PANDEY, Javeena ., Kaptan SINGH, Mohan PRASAD
  • AMORPHOUS FORM OF BARICITINIB
    Publication number: 20170129895
    Abstract: The present invention provides an amorphous form of baricitinib, processes for its preparation, a pharmaceutical composition comprising it, and its use for the treatment of JAK-associated diseases.
    Type: Application
    Filed: March 11, 2015
    Publication date: May 11, 2017
    Inventors: Gyanendra PANDEY, Javeena ., Mohan PRASAD, Kaptan SINGH, Mohan PRASAD
  • PROCESS FOR THE PREPARATION OF 4-DIMETHYLAMINOCROTONIC ACID
    Publication number: 20170107172
    Abstract: The present invention provides a process for the preparation of 4-dimethylaminocrotonic acid of Formula (II) or its salts, which is used as an intermediate for the preparation of afatinib or its salts.
    Type: Application
    Filed: June 2, 2015
    Publication date: April 20, 2017
    Applicant: SUN PHARMACEUTICAL INDUSTRIES LIMITED
    Inventors: Shyam Sunder VERMA, Shravan Kumar SINGH, Kaptan SINGH, Mohan PRASAD
  • Process for the preparation of fosamprenavir calcium
    Patent number: 9085592
    Abstract: The present invention relates to process for the preparation of fosamprenavir calcium.
    Type: Grant
    Filed: September 16, 2010
    Date of Patent: July 21, 2015
    Assignee: RANBAXY LABORATORIES LIMITED
    Inventors: Satish Manohar Bhoge, Prakash Kshirsagar, Santosh Richhariya, Kaptan Singh
  • PROCESS FOR THE PREPARATION OF AZILSARTAN MEDOXOMIL OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF
    Publication number: 20150011774
    Abstract: The present invention relates to a process for the preparation of azilsartan medoxomil or pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: January 30, 2013
    Publication date: January 8, 2015
    Inventors: Md Abul Kalam Azad, Prakash Bhimaji Kshirsagar, Shravan Kumar Singh, Anand Prakash Tiwari, Kaptan Singh, Mohan Prasad, Sudershan Kumar Arora
  • Process for stereoselective synthesis of 5-fluoro-1-(2R,5S)-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine
    Patent number: 8748604
    Abstract: The present invention provides an improved process for stereoselective preparation of 5-fluoro-1-(2R,5S)-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: February 25, 2011
    Date of Patent: June 10, 2014
    Assignee: Ranbaxy Laboratories Limited
    Inventors: Prakash Bhimaji Kshirsagar, Satish Manohar Bhoge, Santosh Richhariya, Kaptan Singh
  • PROCESS FOR STEREOSELECTIVE SYNTHESIS OF 5-FLUORO-1-(2R,5S)-[2-(HYDROXYMETHYL)-1,3-OXATHIOLAN-5-YL]CYTOSINE
    Publication number: 20130072681
    Abstract: The present invention provides an improved process for stereoselective preparation of 5-fluoro-1-(2R,5S)-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine and pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: February 25, 2011
    Publication date: March 21, 2013
    Applicant: RANBAXY LABORATORIES LIMITED
    Inventors: Prakash Bhimaji Kshirsagar, Satish Manohar Bhoge, Santosh Richhariya, Kaptan Singh
  • PROCESSES FOR THE PREPARATION OF FORM I AND FORM II OF PALONOSETRON HYDROCHLORIDE
    Publication number: 20120267533
    Abstract: The present invention relates to processes for the preparation of Form I and Form II of palonosetron hydrochloride. The present invention further relates to a method of determining the polymorphic forms of palonosetron hydrochloride using Fourier-Transform Infra-red (FTIR) method.
    Type: Application
    Filed: June 30, 2010
    Publication date: October 25, 2012
    Applicant: RANBAXY LABORATORIES LIMITED
    Inventors: Gyanendra Pandey, Kaptan Singh, Surender Dhingra, Mohan Prasad, Tippasandra G. Chandrashekhar, Somenath Ganguly, Rita Santhakumar
  • PROCESS FOR THE PREPARATION OF FOSAMPRENAVIR CALCIUM
    Publication number: 20120220786
    Abstract: The present invention relates to process for the preparation of fosamprenavir calcium.
    Type: Application
    Filed: September 16, 2010
    Publication date: August 30, 2012
    Applicant: RANBAXY LABORATORIES LIMITED
    Inventors: Satish Manohar Bhoge, Prakash Kshirsagar, Santosh Richhariya, Kaptan Singh
  • CRYSTALLINE FORM OF FOSAMPRENAVIR CALCIUM
    Publication number: 20120208787
    Abstract: The present invention relates to a crystalline form of fosamprenavir calcium. The crystalline form of the present invention is designated as Form II of fosamprenavir calcium. The present invention also relates to a process for the preparation of crystalline Form II of fosamprenavir calcium. The present invention further relates to a pharmaceutical composition comprising crystalline Form II of fosamprenavir calcium. The present invention relates further to a method of treating a HIV infection using crystalline Form II of fosamprenariv calium.
    Type: Application
    Filed: June 29, 2010
    Publication date: August 16, 2012
    Applicant: RANBAXY LABORATORIES LIMITED
    Inventors: Satish Manohar Bhoge, Prakash Kshirsagar, Santosh Richhariya, Kaptan Singh
  • AMORPHOUS FOSAMPRENAVIR CALCIUM
    Publication number: 20120135965
    Abstract: The present invention relates to amorphous Fosamprenavir calcium and processes for its preparation, a pharmaceutical composition comprising it and a method for treating a HIV infection therewith.
    Type: Application
    Filed: May 20, 2010
    Publication date: May 31, 2012
    Applicant: RANBAXY LABORATORIES LIMITED
    Inventors: Satish Manohar Bhoge, Prakash Kshirsagar, Santosh Richhariya, Anshul Agrawal, Kaptan Singh
  • CRYSTALLINE FORMS OF ATORVASTATIN MAGNESIUM
    Publication number: 20090306173
    Abstract: The present invention relates to crystalline forms of Atorvastatin magnesium and processes for their preparation. The crystalline forms of the present invention are designated as form X, form Y, form Z and form P of atorvastatin magnesium. The present invention further relates to pharmaceutical compositions comprising form X, form Y, form Z and form P of atorvastatin magnesium and method of using the crystalline forms.
    Type: Application
    Filed: June 2, 2009
    Publication date: December 10, 2009
    Inventors: Vipin TYAGI, Wajid Sajjad Jafri, Sanjay Kumar, Saridi Madhava Dileep Kumar, Swargam Sathyanarayana, Kaptan Singh, Mohan Prasad