Abstract: The present invention provides, inter alia, methods for treating or preventing a disorder in a subject exposed to an agent that antagonizes the serotonin reuptake transporter (SERT), such as an SSRI, in utero or by consumption by the subject of breast milk from the subject's mother, by administering a 5-HT4 receptor antagonist, for example, to the subject's mother.

Abstract: The present invention provides, inter alia, methods for treating or ameliorating the effects of a disease associated with altered serotonin transporter molecule (SERT) activity in a subject in need thereof. The methods include administering to the subject an effective amount of a 5-HT4 agonist or a pharmaceutically acceptable salt thereof. Pharmaceutical compositions and kits for the same are also provided. The present invention additionally provides methods for treating or ameliorating the effects of elevated serotonin transporter molecule activity in the gastrointestinal tract of a subject in need thereof and a gastrointestinal abnormality associated with autism spectrum disorder in a subject in need thereof.

Abstract: This invention relates to tryptophan hydroxylase inhibitors, compositions comprising them, and methods of their use for the treatment, management and/or prevention of necrotizing enterocolitis.