Patents by Inventor Kareem Ebeid

Kareem Ebeid has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • UNIVERSAL NON-VIRAL GENE DELIVERY SYSTEM WITH ENHANCED STABILITY
    Publication number: 20260077063
    Abstract: The present disclosure provides, for instance, polymer-lipid hybrid nanoparticle compositions and methods of making and using them. The polymer-lipid hybrid nanoparticle may comprise, for example, poly(lactic-co-glycolic) acid (PLGA), polyethylenimine (PEI), and D-Lin-MC3-DMA (MC3). The polymer-lipid hybrid nanoparticle can be used to deliver, for example, nucleic acids and small molecules, cells.
    Type: Application
    Filed: September 18, 2025
    Publication date: March 19, 2026
    Inventors: Tejal Desai, Kareem Ebeid, Brendan Knittle, Aliasger Salem
  • COMPOSITIONS AND METHODS FOR TREATING CANCER
    Publication number: 20240082238
    Abstract: The invention provides methods, compositions, and kits that are useful for treating cancer (e.g., endometrial cancer).
    Type: Application
    Filed: August 18, 2022
    Publication date: March 14, 2024
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Aliasger K. Salem, Kareem Ebeid, Youssef Wahib Naguib Ibrahim, Sanjib Saha, Emad I. Wafa, Suhaila Alhaj-Suliman
  • CATIONIC NANOPARTICLE ADJUVANTS
    Publication number: 20230293678
    Abstract: A cationic nanoparticle formed of a biodegradable or biocompatible synthetic polymer and a dendrimer having a diameter of about 125 nm to 1000 nm, and methods of using the nanoparticle, e.g., for delivery of an immunogen, are provided.
    Type: Application
    Filed: August 20, 2021
    Publication date: September 21, 2023
    Inventors: Aliasger K. Salem, Sean M. Geary, Kareem Ebeid, Emad I. Wafa, Rasheid Smith
  • NANOPARTICLES COMPRISING QUINONE W METHIDES AND COMPOSITIONS FOR USE
    Publication number: 20220241214
    Abstract: A nanoparticle comprising one or more quinonemethide triterpenoids or one or more inhibitors of metadherin, and methods of using the nanoparticles, are provided.
    Type: Application
    Filed: June 19, 2020
    Publication date: August 4, 2022
    Inventors: Aliasger K. Salem, Kimberly Leslie, Xiangbing Meng, Jianling Bi, Kareem Ebeid, Sudartip Areecheewakul
  • SYNTHETICALLY LETHAL NANOPARTICLES FOR TREATMENT OF CANCERS
    Publication number: 20220110882
    Abstract: Disclosed are nanoparticle compositions and methods for treating cancer in a subject in need thereof. The nanoparticle compositions and methods may be utilized to treat cancers in a subject that are characterized by susceptibility to synthetic lethality via administering a combination of agents that induce synthetic lethality.
    Type: Application
    Filed: November 17, 2021
    Publication date: April 14, 2022
    Inventors: Aliasger K. Salem, Kristina Thiel, Kimberly Leslie, Kareem Ebeid
  • SYNTHETICALLY LETHAL NANOPARTICLES FOR TREATMENT OF CANCERS
    Publication number: 20200390717
    Abstract: Disclosed are nanoparticle compositions and methods for treating cancer in a subject in need thereof. The nanoparticle compositions and methods may be utilized to treat cancers in a subject that are characterized by susceptibility to synthetic lethality via administering a combination of agents that induce synthetic lethality.
    Type: Application
    Filed: November 20, 2018
    Publication date: December 17, 2020
    Inventors: Aliasger K. Salem, Kristina Thiel, Kimberly Leslie, Kareem Ebeid