Patents by Inventor Kareem Rashid Rumah

Kareem Rashid Rumah has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods to protect against and treat multiple sclerosis
    Patent number: 9758573
    Abstract: The invention provides epsilon toxin (ETX) produced by Clostridium perfringens type B or type D as a causative toxin for human multiple sclerosis (MS). The invention further identifies ETX binding receptor MAL for ETX mediated cell death and other toxin-logical activities in MS. Methods and compositions to prevent humans from multiple sclerosis (MS) and/or treating MS by directly or indirectly interfering with epsilon toxin (ETX), its binding receptor (e.g., MAL), or ETX-receptor interactions so as to inhibit or suppress downstream ETX mediated receptor signaling activities are provided. Also provided are various methods to detect, diagnose, monitor, assess multiple sclerosis (MS) by determining an expression level of ETX gene or its encoding protein in human patient suspected for and/or at risk for multiple sclerosis (MS).
    Type: Grant
    Filed: August 14, 2015
    Date of Patent: September 12, 2017
    Assignees: Cornell University, The Rockefeller University
    Inventors: Timothy Vartanian, Kareem Rashid Rumah, Vincent A. Fischetti
  • Methods to Protect Against and Treat Multiple Sclerosis
    Publication number: 20160017022
    Abstract: The invention provides epsilon toxin (ETX) produced by Clostridium perfringens type B or type D as a causative toxin for human multiple sclerosis (MS). The invention further identifies ETX binding receptor MAL for ETX mediated cell death and other toxin-logical activities in MS. Methods and compositions to prevent humans from multiple sclerosis (MS) and/or treating MS by directly or indirectly interfering with epsilon toxin (ETX), its binding receptor (e.g., MAL), or ETX-receptor interactions so as to inhibit or suppress downstream ETX mediated receptor signaling activities are provided. Also provided are various methods to detect, diagnose, monitor, assess multiple sclerosis (MS) by determining an expression level of ETX gene or its encoding protein in human patient suspected for and/or at risk for multiple sclerosis (MS).
    Type: Application
    Filed: August 14, 2015
    Publication date: January 21, 2016
    Inventors: Timothy Vartanian, Kareem Rashid Rumah, Vincent A. Fischetti