Patents by Inventor Karel KNEZ

Karel KNEZ has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Monitoring DNA amplification
    Patent number: 10421990
    Abstract: A method and kits are provided for nucleic acid quantification and discrimination using surface plasmon resonance (SPR). The method provided is able to significantly enhance the detection limit and multiplex the discrimination assay using the melting properties of the target DNA on top of standard PCR reaction. By using the heating and cooling cycles of the polymerase chain reaction (PCR) or Ligation chain reaction (LCR), DNA is melted and hybridized onto the SPR sensor surface together with a nanoparticle label. Thus, during every cycle of DNA amplification, the quantity and type of target DNA can be monitored.
    Type: Grant
    Filed: November 12, 2014
    Date of Patent: September 24, 2019
    Assignee: FOX BIOSYSTEMS NV
    Inventors: Jeroen Lammertyn, Karel Knez, Filip Delport
  • MONITORING DNA AMPLIFICATION
    Publication number: 20160298178
    Abstract: A method and kits are provided for nucleic acid quantification and discrimination using surface plasmon resonance (SPR). The method provided is able to significantly enhance the detection limit and multiplex the discrimination assay using the melting properties of the target DNA on top of standard PCR reaction. By using the heating and cooling cycles of the polymerase chain reaction (PCR) or Ligation chain reaction (LCR), DNA is melted and hybridized onto the SPR sensor surface together with a nanoparticle label. Thus, during every cycle of DNA amplification, the quantity and type of target DNA can be monitored.
    Type: Application
    Filed: November 12, 2014
    Publication date: October 13, 2016
    Inventors: Jeroen LAMMERTYN, Karel KNEZ, Filip DELPORT