Patents by Inventor Karel Konvicka

Karel Konvicka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SYSTEMS AND METHODS FOR DETERMINING COPY NUMBER VARIATION
    Publication number: 20190362810
    Abstract: A method of identifying a copy number variations reads includes mapping reads to a reference genome, computing coverage for a plurality of tiles, and normalizing the coverage for a tile based on a coverage mode across the plurality of tiles. The method further includes determining a score for the plurality of tiles being in a plurality of ploidy states, determining a maximum score path across the tiles and through the ploidy states, and providing a copy number determination based on the maximum score path.
    Type: Application
    Filed: June 12, 2019
    Publication date: November 28, 2019
    Inventors: Karel Konvicka, James Veitch
  • METHODS, SYSTEMS AND PROCESSES OF DE NOVO ASSEMBLY OF SEQUENCING READS
    Publication number: 20190244678
    Abstract: Provided herein are novel methods, systems and processes of mapping and assembling sequence reads. Also provided herein are methods, systems and processes of identifying the presence or absence of a genetic variation in a genome of a subject.
    Type: Application
    Filed: October 9, 2015
    Publication date: August 8, 2019
    Inventors: Karel KONVICKA, Kevin JACOBS
  • Systems and Methods for Determining Copy Number Variation
    Publication number: 20140256571
    Abstract: A method of identifying a copy number variations reads includes mapping reads to a reference genome, computing coverage for a plurality of tiles, and normalizing the coverage for a tile based on a coverage mode across the plurality of tiles. The method further includes determining a score for the plurality of tiles being in a plurality of ploidy states, determining a maximum score path across the tiles and through the ploidy states, and providing a copy number determination based on the maximum score path.
    Type: Application
    Filed: March 5, 2014
    Publication date: September 11, 2014
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventor: Karel Konvicka
  • Markers for addiction
    Patent number: 8080371
    Abstract: Correlations between polymorphisms and addiction are provided. Methods of diagnosing, prognosing, and treating addiction are provided. Systems and kits for diagnosis, prognosis and treatment of addiction are provided. Methods of identifying addiction modulators are also described.
    Type: Grant
    Filed: March 1, 2007
    Date of Patent: December 20, 2011
    Assignee: The Washington University
    Inventors: Dennis Ballinger, Karel Konvicka, Laura Jean Bierut, John Rice, Frank Scott Saccone, Anthony L. Hinrichs, Alison M. Goate, Jen Wang
  • MARKERS FOR ADDICTION
    Publication number: 20070258898
    Abstract: Correlations between polymorphisms and addiction are provided. Methods of diagnosing, prognosing, and treating addiction are provided. Systems and kits for diagnosis, prognosis and treatment of addiction are provided. Methods of identifying addiction modulators are also described.
    Type: Application
    Filed: March 1, 2007
    Publication date: November 8, 2007
    Inventors: Dennis Ballinger, Karel Konvicka, Laura Bierut, John Rice, Frank Saccone, Anthony Hinrichs, Alison Goate, Jen Wang
  • Genetic basis of Alzheimer's disease and diagnosis and treatment thereof
    Publication number: 20060228728
    Abstract: A collection of polymorphic sites having resistance or susceptibility to Alzheimer's disease is provided. The sites are useful in methods of diagnosing and treating Alzheimer's disease and related conditions.
    Type: Application
    Filed: January 31, 2006
    Publication date: October 12, 2006
    Applicant: Perlegen Sciences, Inc.
    Inventors: David Cox, Dennis Ballinger, Erica Beilharz, Karel Konvicka, Laura Stuve
  • Apparatus and methods for analyzing and characterizing nucleic acid sequences
    Publication number: 20050019787
    Abstract: Computer-implemented methods, data processing apparatus and computer program codes for characterizing an interrogation position, such as a SNP position, in a nucleic acid sequence are provided herein. Computer-implemented methods involving various statistical analyses are provided for characterizing an interrogation position as being associated with a phenotypic trait of interest.
    Type: Application
    Filed: January 30, 2004
    Publication date: January 27, 2005
    Applicant: Perlegen Sciences, Inc., a Delaware Corporation
    Inventors: Anthony Berno, Karel Konvicka, David Hinds, Nila Patil, Naiping Shen, David Stern, John Sheehan
  • Analysis methods for individual genotyping
    Publication number: 20040210400
    Abstract: A method and data processing apparatus for determining the genotype of at least one individual from a genetic marker using at least one measure of the amount of an allele of the genetic marker that the individual are described. The method assigns the measure of the amount of an allele to a group, a genotype is then assigned to the group and the individual is determined to have the genotype assigned to the group.
    Type: Application
    Filed: February 24, 2004
    Publication date: October 21, 2004
    Applicant: Perlegen Sciences, Inc.
    Inventor: Karel Konvicka