Patents by Inventor Karel Marie Joseph Brands

Karel Marie Joseph Brands has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS OF CXCR4 INHIBITORS AND METHODS OF PREPARATION AND USE
    Publication number: 20240058322
    Abstract: The present invention provides compositions and methods of use for treating, preventing, or ameliorating a disease, disorder, or condition associated with a chemokine receptor such as CXCR4.
    Type: Application
    Filed: May 4, 2023
    Publication date: February 22, 2024
    Inventor: Karel Marie Joseph BRANDS
  • Compositions of CXCR4 inhibitors and methods of preparation and use
    Patent number: 11672793
    Abstract: The present invention provides compositions and methods of use for treating, preventing, or ameliorating a disease, disorder, or condition associated with a chemokine receptor such as CXCR4.
    Type: Grant
    Filed: June 25, 2021
    Date of Patent: June 13, 2023
    Assignee: X4 Pharmaceuticals, Inc.
    Inventor: Karel Marie Joseph Brands
  • COMPOSITIONS OF CXCR4 INHIBITORS AND METHODS OF PREPARATION AND USE
    Publication number: 20220008410
    Abstract: The present invention provides compositions and methods of use for treating, preventing, or ameliorating a disease, disorder, or condition associated with a chemokine receptor such as CXCR4.
    Type: Application
    Filed: June 25, 2021
    Publication date: January 13, 2022
    Inventor: Karel Marie Joseph Brands
  • Compositions of CXCR4 inhibitors and methods of preparation and use
    Patent number: 11045461
    Abstract: The present invention provides compositions and methods of use for treating, preventing, or ameliorating a disease, disorder, or condition associated with a chemokine receptor such as CXCR4.
    Type: Grant
    Filed: December 5, 2019
    Date of Patent: June 29, 2021
    Assignee: X4 PHARMACEUTICALS, INC.
    Inventor: Karel Marie Joseph Brands
  • CRYSTALLINE SUBSTITUTED CYCLOHEXYL PYRAZOLO[1,5-A]PYRIMIDINYL CARBOXAMIDE COMPOUND AND THERAPEUTIC USES THEREOF
    Publication number: 20200339587
    Abstract: The invention provides crystalline 5,7-dimethyl-N-((1S*,4S)-4-(pentyloxy)cyclohexyl) pyrazolo[1,5-a]pyrimidine-3-carboxamide, compositions containing the crystalline compound, methods for making the crystalline compound, medical kits, and methods for using the crystalline compound and compositions to treat a medical disorder, e.g., Gaucher disease, Parkinson's disease, Lewy body disease, dementia, or multiple system atrophy, in a patient.
    Type: Application
    Filed: December 21, 2018
    Publication date: October 29, 2020
    Inventors: Renato T. Skerlj, Karel Marie Joseph Brands
  • COMPOSITIONS OF CXCR4 INHIBITORS AND METHODS OF PREPARATION AND USE
    Publication number: 20200253953
    Abstract: The present invention provides compositions and methods of use for treating, preventing, or ameliorating a disease, disorder, or condition associated with a chemokine receptor such as CXCR4.
    Type: Application
    Filed: December 5, 2019
    Publication date: August 13, 2020
    Inventor: Karel Marie Joseph Brands
  • Compositions of CXCR4 inhibitors and methods of preparation and use
    Patent number: 10548889
    Abstract: The present invention provides compositions and methods of use for treating, preventing, or ameliorating a disease, disorder, or condition associated with a chemokine receptor such as CXCR4.
    Type: Grant
    Filed: December 11, 2018
    Date of Patent: February 4, 2020
    Assignee: X4 PHARMACEUTICALS, INC.
    Inventor: Karel Marie Joseph Brands
  • Process for the preparation of bicyclo[3.1.0]hexanols
    Patent number: 7834222
    Abstract: A process for the preparation of a the formula (I): which process comprises the intramolecular cyclopropanation of an epoxide of me formula (II); in the presence of 0.05 to 0.75 equivalents of a secondary amine base and at least one equivalent of an alkyl lithium base, wherein R R1, R2 and R3 are each hydrogen or C1-4 alkyl or R1 and R2 are linked to form- a C3-7 cycloaUcyl or C3-7 cycloalkenyl ring.
    Type: Grant
    Filed: August 1, 2006
    Date of Patent: November 16, 2010
    Assignee: Merck Sharp & Dohme Ltd.
    Inventors: Matthew Bio, Karel Marie Joseph Brands, Edward Cleator
  • Process for the Preparation of Bicyclo[3.1.0]Hexanols
    Publication number: 20100099923
    Abstract: A process for the preparation of a the formula (I): which process comprises the intramolecular cyclopropanation of an epoxide of me formula (II); in the presence of 0.05 to 0.75 equivalents of a secondary amine base and at least one equivalent of an alkyl lithium base, wherein R R1, R2 and R3 are each hydrogen or C1-4 alkyl or R1 and R2 are linked to form- a C3-7 cycloaUcyl or C3-7 cycloalkenyl ring.
    Type: Application
    Filed: August 1, 2006
    Publication date: April 22, 2010
    Inventors: Matthew Bio, Karel Marie Joseph Brands, Edward Cleator
  • Stereoselective synthesis of a 4,4-disubstituted cyclohexanepropanoic acid
    Patent number: 7411088
    Abstract: There is provided stereoselective route to a compound of formula I: wherein R represents H or an alkali metal, Ar1 represents 4-chlorophenyl and Ar2 represents 2,5-difluorophenyl.
    Type: Grant
    Filed: February 16, 2005
    Date of Patent: August 12, 2008
    Assignees: Merck & Co., Inc., Merck Sharp & Dohme Ltd.
    Inventors: Karel Marie Joseph Brands, Sarah Elizabeth Brewer, Antony John Davies, Ulf H. Dolling, Deborah Camille Hammond, David Ross Lieberman, Jeremy Peter Scott
  • ? v integrin receptor antagonists
    Patent number: 7288655
    Abstract: The present invention relates to the synthesis of intermediates for the preparation of compounds of formula (A): wherein n is 2 or 3 and various salt forms of these compounds.
    Type: Grant
    Filed: March 4, 2004
    Date of Patent: October 30, 2007
    Assignees: Merck & Co., Inc., Merck Sharp & Dohme Ltd.
    Inventors: Brian Christopher Bishop, Karel Marie Joseph Brands, Ian Frank Cottrell, Cameron John Cowden, Antony John Davies, Stephen Philip Keen, David Ross Lieberman, Gavin William Stewart
  • Synthesis of cyclohexanone derivatives
    Patent number: 7276637
    Abstract: A novel process for preparing cyclohexanone derivatives of formula (I) is described. The products are useful as gamma secretase inhibitors, or as intermediates in the synthesis of other gamma secretase inhibitors.
    Type: Grant
    Filed: July 30, 2003
    Date of Patent: October 2, 2007
    Assignees: Merck Sharp & Dohme Limited, Merck & Co., Inc.
    Inventors: Karel Marie Joseph Brands, Antony John Davies, Paul Joseph Oakley, Jeremy Peter Scott, Duncan Edward Shaw, Martin Richard Teall