Patents by Inventor Karel R. Schubert

Karel R. Schubert has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Trypsin inhibitors with insecticidal properties obtained from Pentaclethra macroloba
    Patent number: 6525175
    Abstract: Compositions and methods for controlling pests, particularly insect pests, are provided. The compositions comprise proteins isolated from plants of the genus Pentaclethra which exhibit trypsin inhibiting activity. Nucleotide sequences encoding the proteins are also provided. Such sequences find use in transforming organisms for control of pests.
    Type: Grant
    Filed: May 28, 1999
    Date of Patent: February 25, 2003
    Assignees: Pioneer Hi-Bred International, Inc., Board of Regents for the University of Oklahoma
    Inventors: Ruzhu Chen, Karel R. Schubert, Thomas H. Czapla
  • Trypsin inhibitors with insecticidal properties obtained from Pentaclethra macroloba
    Patent number: 6384302
    Abstract: Compositions and methods for controlling pests, particularly insect pests, are provided. The compositions comprise proteins isolated from plants of the genus Pentaclethra which exhibit trypsin inhibiting activity. Nucleotide sequences encoding the proteins are also provided. Such sequences find use in transforming organisms for control of pests.
    Type: Grant
    Filed: May 28, 1999
    Date of Patent: May 7, 2002
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventors: Ruzhu Chen, Karel R. Schubert, Thomas H. Czapla
  • Proteins having insecticidal activities and method of use
    Patent number: 6339144
    Abstract: Compositions and methods for controlling pests, particularly insect pests, are provided. The compositions comprise proteins isolated from plants of the genus Pentaclethra. Nucleotide sequences encoding the proteins are also provided. Such sequences find use in transforming organisms for control of pests.
    Type: Grant
    Filed: April 13, 1999
    Date of Patent: January 15, 2002
    Assignees: Board of Regents for University of Oklahoma, Pioneer Hi-Bred International, Inc.
    Inventors: Amy L. Cigan, Thomas Czapla, Patricia Lynne Fallis, Terry Meyer, Scott A. Mundell, Brian T. Sabus, Karel R. Schubert
  • Protein having insecticidal activities and method of use
    Patent number: 6057491
    Abstract: Compositions and methods for controlling pests, particularly insect pests, are provided. The compositions comprise proteins isolated from plants of the genus Pentaclethra. Nucleotide sequences encoding the proteins are also provided. Such sequences find use in transforming organisms for control of pests.
    Type: Grant
    Filed: May 8, 1998
    Date of Patent: May 2, 2000
    Assignees: Borad of Regents for University of Oklahoma, Pioneer Hi-Bred International, Inc.
    Inventors: Amy L. Cigan, Thomas Czapla, Patricia Lynne Fallis, Terry Meyer, Scott A. Mundell, Brian T. Sabus, Karel R. Schubert
  • Trypsin inhibitors with insecticidal properties obtained from pentaclethra macroloba
    Patent number: 5981722
    Abstract: Compositions and methods for controlling pests, particularly insect pests, are provided. The compositions comprise proteins isolated from plants of the genus Pentaclethra which exhibit trypsin inhibiting activity. Nucleotide sequences encoding the proteins are also provided. Such sequences find use in transforming organisms for control of pests.
    Type: Grant
    Filed: September 26, 1997
    Date of Patent: November 9, 1999
    Assignee: Board of Regents for The University of Oklahoma
    Inventors: Ruzhu Chen, Karel R. Schubert, Thomas H. Czapla
  • Pentaclethra macroloba derived substances having insecticide, agglutination and aminopeptidase inhibition activity
    Patent number: 5756661
    Abstract: The invention comprises a leucine aminopeptidase inhibitor (LAPI) having hemagglutination activity which is extracted from the seeds of Pentaclethra macroloba. The crude extract was found to comprise an active species having a molecular weight in the range 1.5-60 kilodaltons and further comprises an amino acid containing component, a fluorescent component and sugars. The basic unit of the active species contains approximately the following type and number of amino acid residues averaged over a plurality of separations and analyses: 3 aspartate, 3 threonine, 4.5 serine, 3.75 glutamic, 6.5 glycine, 3.5 alanine, 2.25 valine, 1.25 isoleucine, 2 leucine, 0.75 tyrosine, 1.25 phenylalanine, 5.25 lysine, 0.75 histidine, 2.25 arginine and 0.625 proline, and forms multimers, adduct, conjugate and similar species between by itself or with proteinaceous, fluorescent and sugar substance which may also be present. The active substance(s) act as an insecticide and have been found to increase insect mortality in bioassays.
    Type: Grant
    Filed: November 15, 1996
    Date of Patent: May 26, 1998
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventors: Karel R. Schubert, Ulrich Reimann-Philipp, Thomas H. Czapla, Harold B. Rathburn
  • Pentaclethera macroloba protein having insecticidal properties
    Patent number: 5672680
    Abstract: The invention comprises purified trypsin inhibitors extracted from the seeds of Pentaclethra macroloba. The crude extract was found to comprise two molecular weight ranges of 38-35 and 6-9 kDa which contain the active compounds. Within each molecular weight range, the trypsin inhibitors were found to exist in two isoforms. The lower molecular weight inhibitor exhibits surprising stability and activity after heating in aqueous solution at approximately 100.degree. C. for 30 minutes.
    Type: Grant
    Filed: November 20, 1995
    Date of Patent: September 30, 1997
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventors: Harold B. Rathburn, Thomas H. Czapla, Karel R. Schubert