Patents by Inventor Karel Six

Karel Six has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of coating stents
    Patent number: 7622145
    Abstract: Processes for coating implantable medical devices that improve the stability of therapeutic agents contained within the coating.
    Type: Grant
    Filed: July 26, 2005
    Date of Patent: November 24, 2009
    Assignee: Cordis Corporation
    Inventors: Eugena A. Akerman, Dirk Cleeren, Gerard Llanos, Cynthia A. Maryanoff, Georgios Papandreou, William Rion, Karel Six, Thomas L. Todd
  • SOLVENT FREE AMORPHOUS RAPAMYCIN
    Publication number: 20080227982
    Abstract: An improved process for coating implantable medical devices utilizes a number of techniques for improving the stability of therapeutic agents contained within the coating. The stability of the therapeutic agents may be improved by creating substantially solvent-free, amorphous forms of the therapeutic agents.
    Type: Application
    Filed: May 27, 2008
    Publication date: September 18, 2008
    Inventors: Cynthia A. Maryanoff, Karel Six, Roger Vandecruys
  • Solid dispersions comprising two different polymer matrixes
    Patent number: 7407670
    Abstract: Present invention provides solid dispersions comprising a poorly soluble bioactive compound dispersed in a polymer matrix characterized in that the polymer matrix comprises more than one polymer. Said solid dispersions effectively stabilize the dispersed compound while stimulating the solubilisation of the compound in an aquaeous environment.
    Type: Grant
    Filed: July 1, 2003
    Date of Patent: August 5, 2008
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Karel Six, Geert Verreck, Jozef Peeters, Marcus Eli Brewster, Guy Van Den Mooter
  • Solvent free amorphous rapamycin
    Patent number: 7393952
    Abstract: An improved process for coating implantable medical devices utilizes a number of techniques for improving the stability of therapeutic agents contained within the coating. The stability of the therapeutic agents may be improved by creating substantially solvent-free, amorphous forms of the therapeutic agents.
    Type: Grant
    Filed: August 24, 2005
    Date of Patent: July 1, 2008
    Assignee: Cordis Corporation
    Inventors: Cynthia A. Maryanoff, Karel Six, Roger Vandecruys
  • Solvent free amorphous rapamycin
    Publication number: 20060128739
    Abstract: An improved process for coating implantable medical devices utilizes a number of techniques for improving the stability of therapeutic agents contained within the coating. The stability of the therapeutic agents may be improved by creating substantially solvent-free, amorphous forms of the therapeutic agents.
    Type: Application
    Filed: August 24, 2005
    Publication date: June 15, 2006
    Inventors: Cynthia Maryanoff, Karel Six, Roger Vandecruys
  • Solid dispersions comprising two different polymer matrixes
    Publication number: 20060062809
    Abstract: Present invention provides solid dispersions comprising a poorly soluble bioactive compound dispersed in a polymer matrix characterized in that the polymer matrix comprises more than one polymer. Said solid dispersions effectively stabilize the dispersed compound while stimulating the solubilisation of the compound in an aquaeous environment.
    Type: Application
    Filed: July 1, 2003
    Publication date: March 23, 2006
    Inventors: Karel Six, Geert Verreck, Jozef Peeters, Marcus Brewster, Guy Van Den Mooter
  • Method of coating stents
    Publication number: 20060024426
    Abstract: Processes for coating implantable medical devices that improve the stability of therapeutic agents contained within the coating.
    Type: Application
    Filed: July 26, 2005
    Publication date: February 2, 2006
    Inventors: Eugena Akerman, Dirk Cleeren, Gerard Llanos, Cynthia Maryanoff, Georgios Papandreou, William Rion, Karel Six, Thomas Todd