Patents by Inventor Karel Wiesner

Karel Wiesner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel isomers of bufalin and resibufogenin and their preparation
    Patent number: 4380624
    Abstract: This invention relates to novel isomers of naturally occurring cardiotonic compounds, specifically novel isobufalins and novel isoresibufogenins. This invention also relates to a novel method of preparing the novel isomers.
    Type: Grant
    Filed: July 31, 1981
    Date of Patent: April 19, 1983
    Assignee: Advance Biofactures Corp.
    Inventors: Karel Wiesner, Thomas Y. R. Tsai
  • Organometallic reagents and their use in the synthesis of cardenolides and isocardenolides
    Patent number: 4331802
    Abstract: A method for synthesizing a cardenolide or isocardenolide by subjecting an .alpha.,.beta.-unsaturated steroidal 17-ketone to a double bond shift and hydrogenation to produce a (C/D cisoid) ketone which is treated with an organometallic reagent to yield a tertiary alcohol and the acidifying said alcohol to produce said cardenolide or isocardenolide is shown. The invention also relates to organometallic reagents particularly useful in such method.
    Type: Grant
    Filed: October 1, 1980
    Date of Patent: May 25, 1982
    Assignee: Advance Biofactures Corporation
    Inventors: Karel Wiesner, Rinaldo Marini-Bettolo, Connie S. J. Tsai, Thomas Y. R. Tsai
  • Synthesis of furyl intermediates, and cardenolides and their isomers prepared therefrom
    Patent number: 4259240
    Abstract: The invention relates to furyl intermediates and the preparation thereof, said intermediates being particularly useful in the preparation of synthetic cardenolides and their isomers. The process provides for the reaction of an unsaturated steroidal 17 ketone with a .beta.-furyl compound to produce an allylic alcohol which is subjected to acetylation and allylic rearrangement. The resulting material is then hydrogenated to produce the furyl intermediate. Cardenolides are formed therefrom by oxidation of the furyl intermediates.
    Type: Grant
    Filed: September 28, 1979
    Date of Patent: March 31, 1981
    Assignee: Advance Biofactures Corporation
    Inventors: Karel Wiesner, Thomas Y. R. Tsai