Patents by Inventor Karen A. Linder

Karen A. Linder has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Rhenium and technetium complexes containing a hypoxia-localizing moiety
    Patent number: 6958141
    Abstract: Novel methods, processes and metal complexes attached to a hypoxia-localizing moiety comprising a metal, preferably radionuclide of rhenium or technetium; a hypoxia-localizing moiety; and, a complexing ligand, wherein said ligand and said radionuclide combined have cell membrane permeabilities greater than that of sucrose, are disclosed.
    Type: Grant
    Filed: December 19, 2003
    Date of Patent: October 25, 2005
    Assignee: Bracco International B.V.
    Inventors: Karen Linder, Adrian D. Nunn, David P. Nowotnik, Kondareddiar Ramalingam, Richard J. DiRocco, William L. Rumsey, John P. Pirro
  • KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
    Publication number: 20050100963
    Abstract: The present invention provides polypeptides, peptide dimer, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a KD<1 ?M), and dimer and multimeric constructs comprising these polypeptides.
    Type: Application
    Filed: September 11, 2003
    Publication date: May 12, 2005
    Applicants: Dyax Corporation
    Inventors: Aaron Sato, Daniel Sexton, Daniel Dransfield, Robert Ladner, Christophe Arbogast, Philippe Bussat, Hong Fan, Sudha Khurana, Karen Linder, Edmund Marinelli, Palaniappa Nanjappan, Adrian Nunn, Radhakrishna Pillai, Sibylle Pochon, Kondareddiar Ramalingam, Ajay Shrivastava, Bo Song, Rolf Swenson, Mathew Von Wronski
  • Radiopharmaceutical formulations
    Publication number: 20050074402
    Abstract: A method is described for inhibiting the degradation of a diagnostic or radiotherapeutic radiopharmaceutical, especially radiolabeled compounds containing reducible moieties, by including oxidants either as a part of the composition for the preparation of such radiopharmaceuticals, or by adding an oxidant to such compositions immediately after the preparation of such radiopharmaceuticals.
    Type: Application
    Filed: October 19, 2001
    Publication date: April 7, 2005
    Inventors: Aldo Cagnolini, Karen Linder, Edmund Marinelli
  • Multivalent constructs for therapeutic and diagnostic applications
    Publication number: 20050027105
    Abstract: The invention provides compositions and methods for therapeutic and diagnostic applications.
    Type: Application
    Filed: September 11, 2003
    Publication date: February 3, 2005
    Inventors: Christophe Arbogast, Philippe Bussat, Hong Fan, Karen Linder, Edmund Marinelli, Palaniappa Nanjappan, Adrian Nunn, Radhakrishna Pillai, Sibylle Pochon, Kondareddiar Ramalingam, Ajay Shrivastava, Bo Song, Rolf Swenson, Mathew Von Wronski, Aaron Sato, Sharon Walker, Daniel Dransfield
  • Rhenium and technetium complexes containing a hypoxia-localizing moiety
    Publication number: 20040191174
    Abstract: Novel methods, processes and metal complexes attached to a hypoxia-localizing moiety comprising
    Type: Application
    Filed: December 19, 2003
    Publication date: September 30, 2004
    Inventors: Karen Linder, Adrian D. Nunn, David P. Nowotnik, Kondareddiar Ramalingam, Richard J. DiRocco, William L. Rumsey, John P. Pirro
  • Rhenium and technetium complexes containing a hypoxia-localizing moiety
    Patent number: 6699458
    Abstract: Novel methods, processes and metal complexes attached to a hypoxia-localizing moiety comprising a metal, preferably radionuclide of rhenium or technetium; a hypoxia-localizing moiety; and, a complexing ligand, wherein said ligand and said radionuclide combined have cell membrane permeabilities greater than that of sucrose, are disclosed.
    Type: Grant
    Filed: November 16, 2001
    Date of Patent: March 2, 2004
    Assignee: Bracco International B.V.
    Inventors: Karen Linder, Adrian D. Nunn, David P. Nowotnik, Kondareddiar Ramalingam, Richard J. DiRocco, William L. Rumsey, John P. Pirro
  • RHENIUM AND TECHNETIUM COMPLEXES CONTAINING A HYPOXIA-LOCALIZING MOIETY
    Publication number: 20040010127
    Abstract: Novel methods, processes and metal complexes attached to a hypoxia-localizing moiety comprising
    Type: Application
    Filed: November 16, 2001
    Publication date: January 15, 2004
    Inventors: Karen Linder, Adrian D. Nunn, David P. Nowotnik, Kondareddiar Ramalingam, Richard J. DiRocco, William L. Rumsey, John P. Pirro
  • Compounds for targeting endothelial cells, compositions containing the same and methods for their use
    Publication number: 20020147136
    Abstract: The present invention provides compounds for targeting endothelial cells, tumor cells or other cells that express the NP-1 receptor, compositions containing the same and methods for their use. Additionally, the present invention includes diagnostic, therapeutic and radiotherapeutic compositions useful for visualization, therapy or radiotherapy.
    Type: Application
    Filed: June 4, 2001
    Publication date: October 10, 2002
    Inventors: Mathew A. Von Wronski, Edmund R. Marinelli, Adrian D. Nunn, Radhakrishna Pillai, Kondareddiar Ramalingam, Michael F. Tweedle, Karen Linder, Palaniappa Nanjappan, Natarajan Raju
  • Rhenium and technetium complexes containing a hypoxia-localizing moiety
    Publication number: 20020054853
    Abstract: Novel methods, processes and metal complexes attached to a hypoxia-localizing moiety comprising
    Type: Application
    Filed: February 5, 2001
    Publication date: May 9, 2002
    Inventors: Karen Linder, Adrian D. Nunn, David P. Nowotnik, Kondareddiar Ramalingam, Richard J. DiRocco, William L. Rumsey, John P. Pirro
  • Rhenium and technetium complexes containing a hypoxia-localizing moiety
    Patent number: 6359120
    Abstract: Novel methods, processes and metal complexes attached to a hypoxia-localizing moiety comprising a metal, preferably radionuclide of rhenium or technetium; a hypoxia-localizing moiety; and, a complexing ligand, wherein said ligand and said radionuclide combined have cell membrane permeabilities greater than that of sucrose, are disclosed.
    Type: Grant
    Filed: February 5, 2001
    Date of Patent: March 19, 2002
    Assignee: Bracco International B.V.
    Inventors: Karen Linder, Adrian D. Nunn, David P. Nowotnik, Kondareddiar Ramalingam, Richard J. DiRocco, William L. Rumsey, John P. Pirro
  • Rhenium and technetium complexes containing a hypoxia-localizing moiety
    Patent number: 6184361
    Abstract: Novel methods, processes and metal complexes attached to a hypoxia-localizing moiety comprising a metal, preferably radionuclide of rhenium or technetium; a hypoxia-localizing moiety; and, a complexing ligand, wherein said ligand and said radionuclide combined have cell membrane permeabilities greater than that of sucrose, are disclosed.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: February 6, 2001
    Assignee: Bracco International B.V.
    Inventors: Karen Linder, Adrian D. Nunn, David P. Nowotnik, Kondareddiar Ramalingam, Richard J. DiRocco, William L. Rumsey, John P. Pirro
  • Rhenium and technetium complexes containing a hypoxia localizing moiety
    Patent number: 5808091
    Abstract: Novel methods, processes and metal complexes attached to a hypoxia-localizing moiety comnprisinga metal, preferably radionuclide of rhenium or technetium;a hypoxia-localizing moiety; and,a complexing ligand, wherein said ligand and said radionuclide combined have cell membrane permeabilities greater than that of sucrose, are disclosed.
    Type: Grant
    Filed: April 3, 1995
    Date of Patent: September 15, 1998
    Assignee: Bracco International B.V.
    Inventors: Karen Linder, Adrian D. Nunn, David P. Nowotnik, Kondareddiar Ramalingam, Richard J. DiRocco, William L. Rumsey, John P. Pirro
  • Diagnostic imaging methods using rhenium and technetium complexes containing a hypoxia-localizing moiety
    Patent number: 5688487
    Abstract: Novel methods, processes and metal complexes attached to a hypoxia-localizing moiety comprisinga metal, preferably radionuclide of rhenium or technetium;a hypoxia-localizing moiety; and,a complexing ligand, wherein said ligand and said radionuclide combined have cell membrane permeabilities greater than that of sucrose, are disclosed.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: November 18, 1997
    Assignee: Bracco International B.V.
    Inventors: Karen Linder, Adrian D. Nunn, David P. Nowotnik, Kondareddiar Ramalingam, Richard J. DiRocco, William L. Rumsey, John P. Pirro