Patents by Inventor Karen A. Selz

Karen A. Selz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Algorithmic design of peptides for binding and/or modulation of the functions of receptors and/or other proteins
    Patent number: 7228238
    Abstract: Methods of synthesizing a peptide or peptide-like molecule to a polypeptide or protein target based on mode-matching each member of a set of peptide constituents of the peptide or peptide-like molecule to peptide constituents of the target polypeptide or protein target.
    Type: Grant
    Filed: February 11, 2004
    Date of Patent: June 5, 2007
    Assignee: Cielo Institute, Inc.
    Inventors: Arnold J. Mandell, Karen A. Selz, Michael F. Shlesinger
  • Algorithmic design of peptides for binding and/or modulation of the functions of receptors and/or other proteins
    Publication number: 20050119454
    Abstract: Methods of synthesizing a peptide or peptide-like molecule to a polypeptide or protein target based on mode-matching each member of a set of peptide constituents of the peptide or peptide-like molecule to peptide constituents of the target polypeptide or protein target for treatment of neurological diseases.
    Type: Application
    Filed: April 2, 2004
    Publication date: June 2, 2005
    Applicant: The Cielo Institute, Inc.
    Inventors: Arnold Mandell, Karen Selz, Michael Shlesinger
  • Algorithmic design of peptides for binding and/or modulation of the functions of receptors and/or other proteins
    Patent number: 6865492
    Abstract: Methods of synthesizing a peptide or peptide-like molecule to a polypeptide or protein target based on mode-matching each member of a set of peptide constituents of the peptide or peptide-like molecule to peptide constituents of the target polypeptide or protein target. Methods are also provided for synthesizing retro-inverso peptides to the mode-matched peptide.
    Type: Grant
    Filed: January 23, 2001
    Date of Patent: March 8, 2005
    Assignee: The Cielo Institute, Inc.
    Inventors: Arnold J. Mandell, Karen A. Selz, Michael F. Shlesinger
  • Algorithmic design of peptides for binding and/or modulation of the functions of receptors and/or other proteins
    Publication number: 20050027457
    Abstract: Methods of synthesizing a peptide or peptide-like molecule to a polypeptide or protein target based on mode-matching each member of a set of peptide constituents of the peptide or peptide-like molecule to peptide constituents of the target polypeptide or protein target.
    Type: Application
    Filed: February 11, 2004
    Publication date: February 3, 2005
    Inventors: Arnold Mandell, Karen Selz, Michael Shlesinger
  • Algorithmic design of peptides for binding and/or modulation of the functions of receptors and/or other proteins
    Publication number: 20030176656
    Abstract: Methods of synthesizing a peptide or peptide-like molecule to a polypeptide or protein target based on mode-matching each member of a set of peptide constituents of the peptide or peptide-like molecule to peptide constituents of the target polypeptide or protein target.
    Type: Application
    Filed: February 26, 2003
    Publication date: September 18, 2003
    Inventors: Arnold J. Mandell, Karen A. Selz, Michael F. Shlesinger
  • Algorithmic design of peptides for binding and/or modulation of the functions of receptors and/or other proteins
    Patent number: 6560542
    Abstract: Methods of synthesizing a peptide or peptide-like molecule to a polypeptide or protein target based on mode-matching each member of a set of peptide constituents of the peptide or peptide-like molecule to peptide constituents of the target polypeptide or protein target.
    Type: Grant
    Filed: January 24, 2000
    Date of Patent: May 6, 2003
    Assignee: The Cielo Institute
    Inventors: Arnold J. Mandell, Karen A. Selz, Michael F. Shlesinger
  • Algorithmic design of peptides for binding and/or modulation of the functions of receptors and/or other proteins
    Publication number: 20020009756
    Abstract: Methods of designing protein-targeted peptides or peptide analogues whose sequences are derived from the target protein sequences, using target protein sequence, analytically derived templates, and relevant distributions of amino acids for weighted random assignments to those templates. The templates are derived from eigenvectors of the autocovariance matrices of the physicochemically-transformed amino acid sequence of the target proteins; wavelet subsequence templates derived from wavelet transformations of the physicochemically-transformed amino acid sequence of the target proteins; and/or non-overlapping redundant subsequence templates computed from the physicochemically-transformed target protein amino acid sequence. The protein targets include cell receptors; transporters; enzymes; chaperonins; antibodies; surface proteins of infectious agents; and any protein involved in protein-protein interactions. The peptides are designed to bind to and/or otherwise modulate the function of the target protein.
    Type: Application
    Filed: January 23, 2001
    Publication date: January 24, 2002
    Inventors: Arnold J. Mandell, Karen A. Selz, Michael F. Shlesinger