Patents by Inventor Karen Bulock

Karen Bulock has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modulation of endogenous AICAR levels for the treatment of diabetes and obesity
    Publication number: 20070015720
    Abstract: The invention relates to methods for treating type 2 diabetes, obesity, metabolic syndrome and conditions associated with these by administering an AICAR-monophosphate (AICAR-MP) enhancing agent that increases endogenous AICAR-MP levels in a cell. Inhibition of AICAR-formyltransferase activity (AICARFT) in a cell that regulates metabolic activity (such as fat, liver, muscle, pancreatic beta or certain brain cells) increases AICAR-monophosphate levels which in turn results in activation of the AMP-kinase (AMPK) pathway, and all of the downstream functions mediated by AMPK including increased fatty acid oxidation, enhanced glucose transport and decreased fatty acid synthesis.
    Type: Application
    Filed: February 3, 2006
    Publication date: January 18, 2007
    Applicant: CytRx Corporation
    Inventors: Karen Bulock, Mark Tepper, John Zhang, Roustem Nabioullin