Abstract: In various examples, techniques for determining perception zones for object detection are described. For instance, a system may use a dynamic model associated with an ego-machine, a dynamic model associated with an object, and one or more possible interactions between the ego-machine and the object to determine a perception zone. The system may then perform one or more processes using the perception zone. For instance, if the system is validating a perception system of the ego-machine, the system may determine whether a detection error associated with the object is a safety-critical error based on whether the object is located within the perception zone. Additionally, if the system is executing within the ego-machine, the system may determine whether the object is a safety-critical object based on whether the object is located within the perception zone.

Abstract: An implantable medical device is provided. The core includes a core polymer matrix within which is dispersed a therapeutic agent comprising one or more aromatase inhibitors. The core polymer matrix contains an ethylene vinyl acetate copolymer. The ethylene vinyl acetate copolymer has a melting temperature of from about 40° C. to about 120° C. as determined in accordance with ASTM D3418-15.

Abstract: An intravaginal ring device is provided. The core includes a core polymer matrix within which is dispersed a therapeutic agent comprising one or more aromatase inhibitors. The core polymer matrix contains an ethylene vinyl acetate copolymer. The ethylene vinyl acetate copolymer has a vinyl acetate content of from about 10 wt. % to about 60 wt. % and/or a melting temperature of from about 40° C. to about 120° C. as determined in accordance with ASTM D3418-15.

Abstract: An implantable medical device is provided. The core includes a core polymer matrix within which is dispersed a therapeutic agent comprising one or more bisphosphonates. The core polymer matrix contains an ethylene vinyl acetate copolymer. The ethylene vinyl acetate copolymer has a vinyl acetate content of from about 10 wt. % to about 60 wt. % and/or a melting temperature of from about 40° C. to about 120° C. as determined in accordance with ASTM D3418-15.

Abstract: The invention provides therapeutic antibodies and methods for treatment of diseases associated with diseases associated with aggregation of ?-synuclein, e.g., in the brain of a subject. Such methods provide administration of therapeutic antibodies to elicit a beneficial immunogenic response against aggregation of ?-synuclein. The methods are particularly useful for prophylactic and therapeutic treatment of diseases associated with the formation of Lewy bodies, e.g., Parkinson's disease.

Abstract: The invention provides therapeutic antibodies and methods for treatment of diseases associated with diseases associated with aggregation of ?-synuclein, e.g., in the brain of a subject. Such methods provide administration of therapeutic antibodies to elicit a beneficial immunogenic response against aggregation of ?-synuclein. The methods are particularly useful for prophylactic and therapeutic treatment of diseases associated with the formation of Lewy bodies, e.g., Parkinson's disease.

Abstract: The invention provides therapeutic antibodies and methods for treatment of diseases associated with diseases associated with aggregation of ?-synuclein, e.g., in the brain of a subject. Such methods provide administration of therapeutic antibodies to elicit a beneficial immunogenic response against aggregation of ?-synuclein. The methods are particularly useful for prophylactic and therapeutic treatment of diseases associated with the formation of Lewy bodies, e.g., Parkinson's disease.

Abstract: The present disclosure provides a method of treating diseases, conditions or disorders associated with fibrosis in a mammal using inhibitors of the Jun N-terminal kinase (JNK) pathway. The present disclosure in particular provides methods of treating diseases, conditions or disorders associated with fibrosis using a specific class of small molecule JNK inhibitors.

Abstract: A single-used matrix sampling device for the single-used, disposable or autoclavble packed-bed bioreactor is provided herein. The present invention includes a tube means and a matrix collecting means. The matrix collecting means configured for collecting the cell culture matrix includes a receptacle and a pulling means connected to the receptacle or the matrix collecting means could be scoop-like in configuration; the tube means is configured for preventing the matrix collecting means from being contaminated while mechanically or pneumatically sampling; and the tube means could be sealed to enclose the sampled matrix collecting means after sampling. A single-used matrix sampling method for a single-used, disposable or autoclavble packed-bed bioreactor is also provided. The present invention could be utilized to aseptically collect the cell culture matrix from the packed-bed bioreactor without requiring to face the risks of contamination.

Abstract: A water floor broom having a spray head that defines an elongated manifold liquid flow passageway communicating with a plurality of liquid spray nozzles, a handle fixed to said body defining a liquid flow passageway communicating with said spray head, and a power washer coupled to said handle for directing pressurized liquid via said handle to said spray head for discharge from the spray nozzles for cleaning a floor surface. The spray head has a light weight, rigid plastic construction that can be operated with lesser quantities of cleaning liquids, and a squeegee blade secured rewardly of the spray head for simultaneously scraping and cleaning water from the floor surface directed onto the floor surface by the spray head for minimizing or eliminating subsequent cleanup.

Abstract: A water floor broom having a spray head that defines an elongated manifold liquid flow passageway communicating with a plurality of liquid spray nozzles, a handle fixed to said body defining a liquid flow passageway communicating with said spray head, and a power washer coupled to said handle for directing pressurized liquid via said handle to said spray head for discharge from the spray nozzles for cleaning a floor surface. The spray head has a light weight, rigid plastic construction that can be operated with lesser quantities of cleaning liquids, and a squeegee blade secured rearwardly of the spray head for simultaneously scraping and cleaning water from the floor surface directed onto the floor surface by the spray head for minimizing or eliminating subsequent cleanup.