Patents by Inventor Karen Chiang

Karen Chiang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Rapamycin resistant cells
    Patent number: 11987804
    Abstract: The present application relates to, inter alia, compositions including proteins for expression in host cells to render them resistant to rapamycin. The application further relates to methods of using the proteins, cells, and compositions disclosed therein for modulating cell signaling and for selective expansion of cells.
    Type: Grant
    Filed: April 25, 2019
    Date of Patent: May 21, 2024
    Assignee: Seattle Children's Hospital
    Inventors: Andrew M. Scharenberg, David J. Rawlings, Karen Sommer, Samuel West, Yuchi Chiang Honaker, Ryo Takeuchi
  • EXPRESSION OF FOXP3 IN EDITED CD34+ CELLS
    Publication number: 20240117352
    Abstract: Aspects of the invention described herein concern the incorporation of a FOXP3 cDNA (e.g., full-length human codon-optimized cDNA) into a FOXP3 gene or a non-FOXP3 locus so as to provide constitutive or regulated FOXP3 expression in a primary human CD34+ cells or cells derived from edited CD34+ cells. In some embodiments, guide RNA sequences that are directed to FOXP3, AAVS1, or other candidate loci are used for CRISPR/Cas9-mediated gene regulation, and gene delivery cassettes for HDR based gene-modification are provided.
    Type: Application
    Filed: June 16, 2023
    Publication date: April 11, 2024
    Inventors: David J. Rawlings, Iram F. Khan, Yuchi Chiang Honaker, Swati Singh, Karen Sommer, Andrew M. Scharenberg
  • MODULATING THE LEVEL OF COMPONENTS WITHIN PLANTS
    Publication number: 20170349908
    Abstract: Materials and methods for identifying lignin regulatory region-regulatory protein associations are disclosed. Materials and methods for modulating lignin accumulation are also disclosed. In addition, methods and materials for modulating (e.g., increasing or decreasing) the level of a component (e.g., protein, oil, lignin, carbon, a carotenoid, or a triterpenoid) in plants are disclosed.
    Type: Application
    Filed: April 27, 2017
    Publication date: December 7, 2017
    Inventors: Steven Craig Bobzin, Nestor Apuya, Karen Chiang, Elena Doukhanina, Kenneth Feldmann, Boris Jankowski, Emilio Margolles-Clark, Daniel Mumenthaler, Jack Okamuro, Joon-Hyun Park, Amr Saad Ragab, Joel Cruz Rarang, Richard Schneeberger, Jennifer E. Van Fleet, Ke Zhang
  • Modulating the level of components within plants
    Patent number: 9758790
    Abstract: Materials and Methods for identifying lignin regulatory region-regulatory protein associations are disclosed. Materials and methods for modulating lignin accumulation are also disclosed. In addition, methods and materials for modulating (e.g., increasing or decreasing) the level of a component (e.g., protein, oil, lignin, carbon, a carotenoid, or a triterpenoid) in plants are disclosed.
    Type: Grant
    Filed: August 13, 2012
    Date of Patent: September 12, 2017
    Assignee: Ceres, Inc.
    Inventors: Steven Craig Bobzin, Nestor Apuya, Karen Chiang, Elena Doukhanina, Kenneth Feldmann, Boris Jankowski, Daniel Mumenthaler, Joon-Hyun Park, Amr Saad Ragab, Joel Cruz Rarang, Richard Schneeberger, Jennifer E. Van Fleet, Ke Zhang
  • MODULATING THE LEVEL OF COMPONENTS WITHIN PLANTS
    Publication number: 20130212735
    Abstract: Materials and Methods for identifying lignin regulatory region-regulatory protein associations are disclosed. Materials and methods for modulating lignin accumulation are also disclosed. In addition, methods and materials for modulating (e.g., increasing or decreasing) the level of a component (e.g., protein, oil, lignin, carbon, a carotenoid, or a triterpenoid) in plants are disclosed.
    Type: Application
    Filed: August 13, 2012
    Publication date: August 15, 2013
    Inventors: Steven Craig Bobzin, Nestor Apuya, Karen Chiang, Elena Doukhanina, Kenneth Feldmann, Boris Jankowski, Emilio Margolles-Clark, Daniel Mumenthaler, Jack Okamuro, Joon-Hyun Park, Amr Saad Ragab, Joel Cruz Rarang, Richard Schneeberger, Jennifer E. Van Fleet, Ke Zhang
  • MODULATING PLANT CAROTENOID LEVELS
    Publication number: 20110113508
    Abstract: Methods and materials for modulating (e.g., increasing or decreasing) carotenoid levels in plants are disclosed. For example, nucleic acids encoding carotenoid-modulating polypeptides are disclosed as well as methods for using such nucleic acids to transform plant cells. Also disclosed are plants having increased carotenoid levels and plant products produced from plants having increased carotenoid levels.
    Type: Application
    Filed: August 20, 2007
    Publication date: May 12, 2011
    Applicant: CERES, INC.
    Inventors: Steven Craig Bobzin, Joon-Hyun Park, Boris Jankowski, Karen Chiang, Amr Saad Ragab