Patents by Inventor Karen Christman

Karen Christman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240090552
    Abstract: Beverages with improved particle suspension properties are disclose, along with methods of making the same. The beverages include a low-acyl gellan gum and insoluble particles. The low-acyl gellan gum undergoes a gel transition that provides adequate gelation to maintain the particles in suspension. The low-acyl gellan gum undergoes the gel transition below a threshold above which the particles and/or a gelled portion of the gum would rise to the top of the beverage via bubbles moving upward through the beverage.
    Type: Application
    Filed: October 14, 2020
    Publication date: March 21, 2024
    Inventors: CAITLIN WERTZ, ABBY CHRISTMAN, KAREN BRIMMER, LIANGJI XU, JAMES BUCHHEIT
  • Patent number: 11786635
    Abstract: Described herein are compositions comprising decellularized extracellular matrix derived from skeletal muscle or other suitable tissue, and therapeutic uses thereof. Methods for treating, repairing or regenerating defective, diseased, damage, ischemic, ulcer cells, tissues or organs in a subject preferably a human, with diseases associated with muscular degeneration, using a decellularized extracellular matrix of the invention are provided. Methods of preparing culture surfaces and culturing cells with absorbed decellularized extracellular matrix are provided.
    Type: Grant
    Filed: June 6, 2022
    Date of Patent: October 17, 2023
    Assignee: The Regents of the University of California
    Inventors: Karen Christman, Marianna Alperin, Pamela Duran
  • Publication number: 20230027018
    Abstract: Methods and hydrogels for preventing or reducing cellular adhesion and protein adsorption to a tissue (e.g. cardiac tissue) are disclosed. The hydrogels generally include at least three component polymers, a first polymer including an aminooxy group, a second polymer including a reactive oxo group, that are cross-linked by oxime bonds and a third polymer including a catechol group, that causes better retention on the cardiac tissue. The hydrogels are suitable for binding to and coating a tissue or cell. The hydrogels operate to reduce cellular adhesions and protein adsorption to the tissue or cell.
    Type: Application
    Filed: August 5, 2022
    Publication date: January 26, 2023
    Inventors: Karen Christman, Masaki Fujita, Michael Madani
  • Publication number: 20220296776
    Abstract: Described herein are compositions comprising decellularized extracellular matrix derived from skeletal muscle or other suitable tissue, and therapeutic uses thereof. Methods for treating, repairing or regenerating defective, diseased, damage, ischemic, ulcer cells, tissues or organs in a subject preferably a human, with diseases associated with muscular degeneration, using a decellularized extracellular matrix of the invention are provided. Methods of preparing culture surfaces and culturing cells with absorbed decellularized extracellular matrix are provided.
    Type: Application
    Filed: June 6, 2022
    Publication date: September 22, 2022
    Inventors: Karen Christman, Marianna Alperin, Pamela Duran
  • Patent number: 11440992
    Abstract: Methods and hydrogels for preventing or reducing cellular adhesion and protein adsorption to a tissue (e.g. cardiac tissue) are disclosed. The hydrogels generally include at least three component polymers, a first polymer including an aminooxy group, a second polymer including a reactive oxo group, that are cross-linked by oxime bonds and a third polymer including a catechol group, that causes better retention on the cardiac tissue. The hydrogels are suitable for binding to and coating a tissue or cell. The hydrogels operate to reduce cellular adhesions and protein adsorption to the tissue or cell.
    Type: Grant
    Filed: March 27, 2018
    Date of Patent: September 13, 2022
    Assignee: The Regents of the University of California
    Inventors: Karen Christman, Masaki Fujita, Michael Madani
  • Patent number: 11376346
    Abstract: Described herein are compositions comprising decellularized extracellular matrix derived from skeletal muscle or other suitable tissue, and therapeutic uses thereof. Methods for treating, repairing or regenerating defective, diseased, damage, ischemic, ulcer cells, tissues or organs in a subject preferably a human, with diseases associated with muscular degeneration, using a decellularized extracellular matrix of the invention are provided. Methods of preparing culture surfaces and culturing cells with absorbed decellularized extracellular matrix are provided.
    Type: Grant
    Filed: May 16, 2018
    Date of Patent: July 5, 2022
    Assignee: The Regents of the University of California
    Inventors: Karen Christman, Marianna Alperin, Pamela Duran
  • Publication number: 20210379245
    Abstract: Compositions and methods for their manufacture and use are provided comprising a soluble extracellular matrix fraction for intravascular delivery which forms a gel or coating in situ for treatment of myocardial infarction and ischemia in a variety of tissues and endothelial injury/dysfunction.
    Type: Application
    Filed: October 25, 2019
    Publication date: December 9, 2021
    Inventors: Karen Christman, Martin Spang, Gregory Grover
  • Publication number: 20210260134
    Abstract: Described herein are compositions comprising decellularized cardiac extracellular matrix and therapeutic uses thereof. Methods for treating, repairing or regenerating defective, diseased, damaged or ischemic cells, tissues or organs in a subject, preferably a human, using a decellularized cardiac extracellular matrix of the invention are provided. Methods of preparing cardiomyocyte culture surfaces and culturing cells with absorbed decellularized cardiac extracellular matrix are provided.
    Type: Application
    Filed: December 28, 2020
    Publication date: August 26, 2021
    Inventors: Karen Christman, Jennifer Singelyn, Jessica DeQuach
  • Publication number: 20200276360
    Abstract: Provided herein are methods and compositions for cardiac therapy. Such compositions include extracellular-matrix (ECM)-based products that can be used to support tissue repair. The compositions can be used for various purposes. In some cases, they can be introduced into a subject in order to preserve and/or repair damaged heart tissue.
    Type: Application
    Filed: October 4, 2019
    Publication date: September 3, 2020
    Applicant: The Regents of the University of California
    Inventors: Karen CHRISTMAN, Jennifer SINGELYN, Jessica DEQUACH
  • Publication number: 20200197567
    Abstract: Described herein are compositions comprising decellularized extracellular matrix derived from skeletal muscle or other suitable tissue, and therapeutic uses thereof. Methods for treating, repairing or regenerating defective, diseased, damage, ischemic, ulcer cells, tissues or organs in a subject preferably a human, with diseases associated with muscular degeneration, using a decellularized extracellular matrix of the invention are provided. Methods of preparing culture surfaces and culturing cells with absorbed decellularized extracellular matrix are provided.
    Type: Application
    Filed: May 16, 2018
    Publication date: June 25, 2020
    Inventors: Karen Christman, Samuel Ward, Marianna Alperin, Pamela Duran
  • Patent number: 10611880
    Abstract: Methods and hydrogels for preventing or reducing cellular adhesion and protein adsorption to a tissue (e.g. cardiac tissue) are disclosed. The hydrogels generally include at least two component polymers, a first polymer including an aminooxy group and a second polymer including a reactive oxo group, that are cross-linked by oxime bonds. The hydrogels are suitable for binding to and coating a tissue or cell. The hydrogels operate to reduce cellular adhesions and protein adsorption to the tissue or cell.
    Type: Grant
    Filed: December 9, 2015
    Date of Patent: April 7, 2020
    Assignee: The Regents of the University of California
    Inventors: Karen Christman, Gregory Grover, Michael Madani, Masaki Fujita
  • Publication number: 20200102422
    Abstract: Methods and hydrogels for preventing or reducing cellular adhesion and protein adsorption to a tissue (e.g. cardiac tissue) are disclosed. The hydrogels generally include at least three component polymers, a first polymer including an aminooxy group, a second polymer including a reactive oxo group, that are cross-linked by oxime bonds and a third polymer including a catechol group, that causes better retention on the cardiac tissue. The hydrogels are suitable for binding to and coating a tissue or cell. The hydrogels operate to reduce cellular adhesions and protein adsorption to the tissue or cell.
    Type: Application
    Filed: March 27, 2018
    Publication date: April 2, 2020
    Inventors: Karen Christman, Masaki Fujita, Michael Madani
  • Patent number: 10456501
    Abstract: Provided herein are methods and compositions for cardiac therapy. Such compositions include extracellular-matrix (ECM)-based products that can be used to support tissue repair. The compositions can be used for various purposes. In some cases, they can be introduced into a subject in order to preserve and/or repair damaged heart tissue.
    Type: Grant
    Filed: September 18, 2017
    Date of Patent: October 29, 2019
    Assignee: Ventrix, Inc.
    Inventors: Karen Christman, Jennifer Singelyn, Jessica Dequach
  • Patent number: 10251977
    Abstract: Described herein are compositions comprising decellularized extracellular matrix derived from skeletal muscle or other suitable tissue, and therapeutic uses thereof. Methods for treating, repairing or regenerating defective, diseased, damage, ischemic, ulcer cells, tissues or organs in a subject preferably a human, with diseases, such as PAD and CLI, using a decellularized extracellular matrix of the invention are provided. Methods of preparing culture surfaces and culturing cells with absorbed decellularized extracellular matrix are provided.
    Type: Grant
    Filed: October 19, 2016
    Date of Patent: April 9, 2019
    Assignee: The Regents of the University of California
    Inventors: Karen Christman, Jessica DeQuach
  • Publication number: 20180071432
    Abstract: Provided herein are methods and compositions for cardiac therapy. Such compositions include extracellular-matrix (ECM)-based products that can be used to support tissue repair. The compositions can be used for various purposes. In some cases, they can be introduced into a subject in order to preserve and/or repair damaged heart tissue.
    Type: Application
    Filed: September 18, 2017
    Publication date: March 15, 2018
    Inventors: Karen CHRISTMAN, Jennifer SINGELYN, Jessica DEQUACH, Adam KINSEY
  • Publication number: 20170362380
    Abstract: Methods and hydrogels for preventing or reducing cellular adhesion and protein adsorption to a tissue (e.g. cardiac tissue) are disclosed. The hydrogels generally include at least two component polymers, a first polymer including an aminooxy group and a second polymer including a reactive oxo group, that are cross-linked by oxime bonds. The hydrogels are suitable for binding to and coating a tissue or cell. The hydrogels operate to reduce cellular adhesions and protein adsorption to the tissue or cell.
    Type: Application
    Filed: December 9, 2015
    Publication date: December 21, 2017
    Inventors: Karen Christman, Gregory Grover, Michael Madani, Masaki Fujita
  • Patent number: 9789224
    Abstract: Provided herein are methods and compositions for cardiac therapy. Such compositions include extracellular-matrix (ECM)-based products that can be used to support tissue repair. The compositions can be used for various purposes. In some cases, they can be introduced into a subject in order to preserve and/or repair damaged heart tissue.
    Type: Grant
    Filed: August 24, 2011
    Date of Patent: October 17, 2017
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Karen Christman, Jennifer Singelyn, Jessica Dequach
  • Publication number: 20170087275
    Abstract: Described herein are compositions comprising decellularized extracellular matrix derived from skeletal muscle or other suitable tissue, and therapeutic uses thereof. Methods for treating, repairing or regenerating defective, diseased, damage, ischemic, ulcer cells, tissues or organs in a subject preferably a human, with diseases, such as PAD and CLI, using a decellularized extracellular matrix of the invention are provided. Methods of preparing culture surfaces and culturing cells with absorbed decellularized extracellular matrix are provided.
    Type: Application
    Filed: October 19, 2016
    Publication date: March 30, 2017
    Inventors: Karen Christman, Jessica DeQuach
  • Patent number: 9592256
    Abstract: Described herein are compositions comprising decellularized extracellular matrix derived from skeletal muscle or other suitable tissue, and therapeutic uses thereof. Methods for treating, repairing or regenerating defective, diseased, damage, ischemic, ulcer cells, tissues or organs in a subject preferably a human, with diseases, such as PAD and CLI, using a decellularized extracellular matrix of the invention are provided. Methods of preparing culture surfaces and culturing cells with absorbed decellularized extracellular matrix are provided.
    Type: Grant
    Filed: February 28, 2014
    Date of Patent: March 14, 2017
    Assignee: The Regents of the University of California
    Inventors: Karen Christman, Jessica DeQuach
  • Patent number: 9534007
    Abstract: A composition and method for treating excess cyanide and hydrogen sulfide comprising administering a cobinamide. Further a method for determining extent of binding by an agent to an extracellular matrix.
    Type: Grant
    Filed: December 23, 2013
    Date of Patent: January 3, 2017
    Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE AIR FORCE
    Inventors: Gerry Boss, Adriano Chan, Matthew Brenner, Sari Brenner-Mahon, Vikhyat S. Bebarta, Jingjing Jiang, Karen Christman, Jean Wang Wassenaar