Patents by Inventor Karen Daniel
Karen Daniel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11904123Abstract: Intravesical drug delivery devices are provided which may include an elongated body formed of a matrix system of a drug dispersed in a silicone, wherein the elongated body has a first end, an opposed second end, and an intermediate portion between the first and second ends, and wherein the silicone of the matrix system is cured to bias the elongated body in a coiled retention shape, such that the device is elastically deformable between a relatively straightened shape suited for insertion of the device through a urethra and into the urinary bladder of a patient and the coiled retention shape which is suited to retain the device within the urinary bladder.Type: GrantFiled: August 10, 2020Date of Patent: February 20, 2024Assignee: TARIS Biomedical LLCInventors: Heejin Lee, Karen Daniel
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Publication number: 20220347091Abstract: Drug delivery devices and methods are provided for administering gemcitabine to a patient in need of treatment of bladder cancer by intravesically administering gemcitabine into the bladder of the patient to achieve a sustained concentration of the gemcitabine in urine in the bladder sufficient to produce a therapeutically effective concentration of the gemcitabine in the tissues of the bladder. In embodiments, the local administration into the patient's bladder is at a mean average amount of from 1 mg/day to about 300 mg/day of the gemcitabine (FBE).Type: ApplicationFiled: July 7, 2022Publication date: November 3, 2022Inventors: Dennis Giesing, Heejin Lee, Karen Daniel
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Publication number: 20220211987Abstract: Implantable drug delivery devices include a housing having a closed drug reservoir lumen bounded by a first wall structure and a hydrophilic second wall structure, and a drug contained in the drug reservoir lumen, wherein the first wall structure is impermeable to the drug and the second wall structure is permeable to the drug. Methods of providing controlled release of drug to a patient include deploying a drug delivery device in the patient releasing a drug from the drug reservoir lumen via diffusion through the second wall structure.Type: ApplicationFiled: March 25, 2022Publication date: July 7, 2022Inventors: Heejin Lee, Karen Daniel, Matthew Sansone
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Publication number: 20220117886Abstract: Drug delivery devices and methods are provided for administering gemcitabine to a patient in need of treatment of bladder cancer by intravesically administering gemcitabine into the bladder of the patient to achieve a sustained concentration of the gemcitabine in urine in the bladder sufficient to produce a therapeutically effective concentration of the gemcitabine in the tissues of the bladder. In embodiments, the local administration into the patient's bladder is at a mean average amount of from 1 mg/day to about 300 mg/day of the gemcitabine (FBE).Type: ApplicationFiled: December 23, 2021Publication date: April 21, 2022Inventors: Dennis Giesing, Heejin Lee, Karen Daniel
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Patent number: 11285304Abstract: Implantable drug delivery devices include a housing having a closed drug reservoir lumen bounded by a first wall structure and a hydrophilic second wall structure, and a drug contained in the drug reservoir lumen, wherein the first wall structure is impermeable to the drug and the second wall structure is permeable to the drug. Methods of providing controlled release of drug to a patient include deploying a drug delivery device in the patient releasing a drug from the drug reservoir lumen via diffusion through the second wall structure.Type: GrantFiled: May 7, 2019Date of Patent: March 29, 2022Assignee: TARIS Biomedical LLCInventors: Heejin Lee, Karen Daniel, Matthew Sansone
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Publication number: 20210401741Abstract: Implantable devices and methods for delivery of lidocaine or other drugs to a patient are provided. In one embodiment, the device includes a first drug portion which has a first drug housing which contains a first drug formulation in a solid form which includes a pharmaceutically acceptable salt of lidocaine; and a second drug portion which includes a second drug housing which contains a second drug formulation which includes lidocaine base. In another embodiment, the device includes a drug reservoir component which has an elastic tube having at least one lumen bounded by a porous sidewall having an open-cell structure, a closed-cell structure, or a combination thereof; and a drug formulation contained within the at least one lumen, wherein the device is deformable between a low-profile deployment shape and a relatively expanded retention shape.Type: ApplicationFiled: September 9, 2021Publication date: December 30, 2021Inventors: Heejin Lee, Michael J. Cima, Karen Daniel, Cheryl Larrivee-Elkins
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Publication number: 20210386978Abstract: Drug delivery devices and systems, are provided for delivery of a drug into the upper urinary tract of patients in need thereof. The drug delivery devices (100) may be deployed directly into the renal pelvis via a patient's ureter, bladder, and urethra, and the drug delivery devices can be wholly retained therein for local continuous, controlled release of a drug over an extended period.Type: ApplicationFiled: November 8, 2019Publication date: December 16, 2021Inventors: Emily Abbate, Karen Daniel, John Caulkins, Hong Linh HO DUC, Erik Greenaway
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Patent number: 11135161Abstract: Implantable devices and methods for delivery of lidocaine or other drugs to a patient are provided. In one embodiment, the device includes a first drug portion which has a first drug housing which contains a first drug formulation in a solid form which includes a pharmaceutically acceptable salt of lidocaine; and a second drug portion which includes a second drug housing which contains a second drug formulation which includes lidocaine base. In another embodiment, the device includes a drug reservoir component which has an elastic tube having at least one lumen bounded by a porous sidewall having an open-cell structure, a closed-cell structure, or a combination thereof; and a drug formulation contained within the at least one lumen, wherein the device is deformable between a low-profile deployment shape and a relatively expanded retention shape.Type: GrantFiled: November 17, 2017Date of Patent: October 5, 2021Assignee: TARIS BIOMEDICAL LLPInventors: Heejin Lee, Michael J. Cima, Karen Daniel, Cheryl Larrivee-Elkins
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Publication number: 20210146013Abstract: Drug delivery devices are provided in which much of a drug payload within the device remains within an area proximal to a wall of the device through which the drug must pass for release of the drug from the device into a patient. In one case, the device may include a drug reservoir portion which has a drug reservoir lumen bounded by a reservoir wall having an inner surface; a drug located in the drug reservoir lumen; and a core region which does not comprise the drug, wherein the drug is disposed between the inner surface of the reservoir wall and the core region. The device may be elastically deformable between a first shape suited for insertion through a lumen into a body cavity of the patient and a second shape suited to retain the device within the body cavity.Type: ApplicationFiled: January 26, 2021Publication date: May 20, 2021Inventors: Heejin LEE, Karen DANIEL, Cheryl LARRIVEE-ELKINS, Vikas AGARWAL, Hong Linh HO DUC
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Patent number: 10933170Abstract: Drug delivery devices are provided in which much of a drug payload within the device remains within an area proximal to a wall of the device through which the drug must pass for release of the drug from the device into a patient. In one case, the device may include a drug reservoir portion which has a drug reservoir lumen bounded by a reservoir wall having an inner surface; a drug located in the drug reservoir lumen; and a core region which does not comprise the drug, wherein the drug is disposed between the inner surface of the reservoir wall and the core region. The device may be elastically deformable between a first shape suited for insertion through a lumen into a body cavity of the patient and a second shape suited to retain the device within the body cavity.Type: GrantFiled: May 12, 2015Date of Patent: March 2, 2021Assignee: TARIS Biomedical LLCInventors: Heejin Lee, Karen Daniel, Cheryl Larrivee-Elkins, Vikas Agarwal, Hong Linh Ho Duc
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Publication number: 20200368508Abstract: Intravesical drug delivery devices are provided which may include an elongated body formed of a matrix system of a drug dispersed in a silicone, wherein the elongated body has a first end, an opposed second end, and an intermediate portion between the first and second ends, and wherein the silicone of the matrix system is cured to bias the elongated body in a coiled retention shape, such that the device is elastically deformable between a relatively straightened shape suited for insertion of the device through a urethra and into the urinary bladder of a patient and the coiled retention shape which is suited to retain the device within the urinary bladder.Type: ApplicationFiled: August 10, 2020Publication date: November 26, 2020Inventors: Heejin Lee, Karen Daniel
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Publication number: 20200368509Abstract: Intravesical drug delivery devices are provided which may include an elongated body formed of a matrix system of a drug dispersed in a silicone, wherein the elongated body has a first end, an opposed second end, and an intermediate portion between the first and second ends, and wherein the silicone of the matrix system is cured to bias the elongated body in a coiled retention shape, such that the device is elastically deformable between a relatively straightened shape suited for insertion of the device through a urethra and into the urinary bladder of a patient and the coiled retention shape which is suited to retain the device within the urinary bladder.Type: ApplicationFiled: August 10, 2020Publication date: November 26, 2020Inventors: Heejin Lee, Karen Daniel
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Publication number: 20200360574Abstract: Implantable drug delivery devices include a housing defining a reservoir, a first unit within the reservoir, and a second unit within the reservoir. The first unit contains a drug and the second unit contains a functional agent that facilitates release of the drug. Intravesical drug delivery devices include a housing portion containing a drug formulation and a housing portion containing an excipient, and are configured to release the drug according to a first release profile and the excipient according to a second release profile. Methods include inserting any of these devices into a patient and releasing drug from the device.Type: ApplicationFiled: August 3, 2020Publication date: November 19, 2020Inventors: Heejin LEE, Karen DANIEL, Matthew SANSONE
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Publication number: 20200353131Abstract: Implantable drug delivery devices include a housing defining a reservoir, a first unit within the reservoir, and a second unit within the reservoir. The first unit contains a drug and the second unit contains a functional agent that facilitates release of the drug. Intravesical drug delivery devices include a housing portion containing a drug formulation and a housing portion containing an excipient, and are configured to release the drug according to a first release profile and the excipient according to a second release profile. Methods include inserting any of these devices into a patient and releasing drug from the device.Type: ApplicationFiled: July 23, 2020Publication date: November 12, 2020Inventors: Heejin LEE, Karen DANIEL, Matthew SANSONE
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Patent number: 10737078Abstract: Intravesical drug delivery devices are provided which may include an elongated body formed of a matrix system of a drug dispersed in a silicone, wherein the elongated body has a first end, an opposed second end, and an intermediate portion between the first and second ends, and wherein the silicone of the matrix system is cured to bias the elongated body in a coiled retention shape, such that the device is elastically deformable between a relatively straightened shape suited for insertion of the device through a urethra and into the urinary bladder of a patient and the coiled retention shape which is suited to retain the device within the urinary bladder.Type: GrantFiled: June 26, 2015Date of Patent: August 11, 2020Assignee: TARIS Biomedical LLCInventors: Heejin Lee, Karen Daniel
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Patent number: 10729823Abstract: Implantable drug delivery devices include a housing defining a reservoir, a first unit within the reservoir, and a second unit within the reservoir. The first unit contains a drug and the second unit contains a functional agent that facilitates release of the drug. Intravesical drug delivery devices include a housing portion containing a drug formulation and a housing portion containing an excipient, and are configured to release the drug according to a first release profile and the excipient according to a second release profile. Methods include inserting any of these devices into a patient and releasing drug from the device.Type: GrantFiled: August 19, 2014Date of Patent: August 4, 2020Assignee: TARIS Biomedical LLCInventors: Heejin Lee, Karen Daniel, Matthew Sansone
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Publication number: 20190329011Abstract: Implantable drug delivery devices include a housing having a closed drug reservoir lumen bounded by a first wall structure and a hydrophilic second wall structure, and a drug contained in the drug reservoir lumen, wherein the first wall structure is impermeable to the drug and the second wall structure is permeable to the drug. Methods of providing controlled release of drug to a patient include deploying a drug delivery device in the patient releasing a drug from the drug reservoir lumen via diffusion through the second wall structure.Type: ApplicationFiled: May 7, 2019Publication date: October 31, 2019Inventors: Heejin Lee, Karen Daniel, Matthew Sansone
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Patent number: 10315019Abstract: Implantable drug delivery devices include a housing having a closed drug reservoir lumen bounded by a first wall structure and a hydrophilic second wall structure, and a drug contained in the drug reservoir lumen, wherein the first wall structure is impermeable to the drug and the second wall structure is permeable to the drug. Methods of providing controlled release of drug to a patient include deploying a drug delivery device in the patient releasing a drug from the drug reservoir lumen via diffusion through the second wall structure.Type: GrantFiled: March 17, 2014Date of Patent: June 11, 2019Assignee: TARIS BIOMEDICAL LLCInventors: Heejin Lee, Karen Daniel, Matthew Sansone
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Patent number: 10286199Abstract: Implantable drug delivery devices include a housing having a closed drug reservoir lumen bounded by a first wall structure and a hydrophilic second wall structure, and a drug contained in the drug reservoir lumen, wherein the first wall structure is impermeable to the drug and the second wall structure is permeable to the drug. Methods of providing controlled release of drug to a patient include deploying a drug delivery device in the patient releasing a drug from the drug reservoir lumen via diffusion through the second wall structure.Type: GrantFiled: August 8, 2016Date of Patent: May 14, 2019Assignee: TARIS BIOMEDICAL LLCInventors: Heejin Lee, Karen Daniel, Matthew Sansone
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Patent number: 10137287Abstract: A drug delivery device is provided. In an embodiment, the device includes a device body having an elongated drug reservoir lumen, a drug positioned in the drug reservoir lumen, and at least one end plug positioned at an end of the device body, for example inserted in an end of the drug reservoir lumen. The end plug may include an aperture therethough, and the drug delivery device may be configured to release the drug from the drug reservoir lumen through the aperture.Type: GrantFiled: March 5, 2014Date of Patent: November 27, 2018Assignee: TARIS Biomedical LLCInventors: Matthew Sansone, Karen Daniel, Grace Kim, Heejin Lee