Patents by Inventor Karen Dorfman

Karen Dorfman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Gene-targeted non-human mammal with human FAD presenilin mutation and generational offspring
    Publication number: 20040154047
    Abstract: The present invention provides a gene-targeted, non-human mammal having a gene encoding a mutant protein product of a mutated FAD presenilin-1 (PS-1) gene, a human FAD Swedish mutation, and a humanized A&bgr; mutation, and generational offspring thereof and a gene-targeted, non-human mammal having a gene encoding a mutant protein product of a mutated FAD PS-1 gene and a human Swedish APP695 mutation, and generational offspring thereof, as well as methods of identifying compounds useful in treating Alzheimer's disease, and to methods of treating Alzheimer's disease.
    Type: Application
    Filed: March 10, 2004
    Publication date: August 5, 2004
    Applicant: Cephalon, Inc.
    Inventors: Richard W. Scott, Andrew G. Reaume, Karen Dorfman
  • Gene-targeted non-human mammal with human fad presenilin mutation and generational offspring
    Patent number: 6734336
    Abstract: The present invention provides a gene-targeted, non-human mammal having a gene encoding a mutant protein product of a mutated FAD presenilin-1 (PS-1) gene, a human FAD Swedish mutation, and a humanized A&bgr; mutation, and generational offspring thereof and a gene-targeted, non-human mammal having a gene encoding a mutant protein product of a mutated FAD PS-1 gene and a human Swedish APP695 mutation, and generational offspring thereof, as well as methods of identifying compounds useful in treating Alzheimer's disease, and to methods of treating Alzheimer's disease.
    Type: Grant
    Filed: July 20, 2000
    Date of Patent: May 11, 2004
    Assignee: Cephalon, Inc.
    Inventors: Richard W. Scott, Andrew G. Reaume, Karen Dorfman
  • Gene-targeted non-human mammal with a human fad presenilin mutation and generational offspring
    Patent number: 6284944
    Abstract: This invention discloses a gene-targeted non-human mammal and generational offspring with respect to the gene encoding a mutant protein product of a mutated presenilin 1 gene (PS-1); more specifically, a gene-targeted mouse with respect to the gene sequence encoding the mutant protein product of PS-1 which has been mutated to contain the human P264L mutation. Methods for screening chemical compounds using such mammals are also disclosed.
    Type: Grant
    Filed: March 10, 1998
    Date of Patent: September 4, 2001
    Assignee: Cephalon, Inc,
    Inventors: Richard W. Scott, Andrew G. Reaume, Karen Dorfman