Abstract: Described herein are methods of identifying a plurality of polynucleotides, as well as detecting presence, absence, or abundance of a plurality of taxa in a sample. Also provided are systems for performing methods of the disclosure.

Abstract: The present disclosure provides methods and systems for prioritizing phenotype-causing genomic variants. The methods include using variant prioritization analyses and in combination with biomedical ontologies using a sophisticated re-ranking methodology to re-rank these variants based on phenotype information. The methods can be useful in any genomics study and diagnostics; for example, rare and common disease gene discovery, tumor growth mutation detection, drug responder studies, metabolic studies, personalized medicine, agricultural analysis, and centennial analysis.

Abstract: Described herein are methods of identifying a plurality of polynucleotides, as well as detecting presence, absence, or abundance of a plurality of taxa in a sample. Also provided are systems for performing methods of the disclosure.

Abstract: The present disclosure provides methods and systems for reprioritizing a first set of strings based on at least a node annotation to generate a second set of strings. One or more graphical representations comprising machine readable data in annotated nodes may be used to score a first set of strings. To score a first set of strings based on one or more node annotations, a seed node may be selected based on a node annotation corresponding to the first set of strings and a first value may be assigned to the seed node. Information may be propagated from a seed node to neighboring nodes and second values may be assigned to neighboring nodes. A score may be generated from at least a first value and a second value.

Abstract: Described herein are methods of identifying a plurality of polynucleotides, as well as detecting presence, absence, or abundance of a plurality of taxa in a sample. Also provided are systems for performing methods of the disclosure.

Abstract: The present disclosure provides methods and systems for prioritizing phenotype-causing genomic variants. The methods include using variant prioritization analyses and in combination with biomedical ontologies using a sophisticated re-ranking methodology to re-rank these variants based on phenotype information. The methods can be useful in any genomics study and diagnostics; for example, rare and common disease gene discovery, tumor growth mutation detection, drug responder studies, metabolic studies, personalized medicine, agricultural analysis, and centennial analysis.