Patents by Inventor Karen Engel
Karen Engel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10961221Abstract: The present application relates to novel substituted piperidinyltetrahydroquinolines, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of diabetic microangiopathies, diabetic ulcers on the extremities, in particular for promoting wound healing of diabetic foot ulcers, diabetic heart failure, diabetic coronary microvascular heart disorders, peripheral and cardial vascular disorders, thromboembolic disorders and ischaemias, peripheral circulatory disturbances, Raynaud's phenomenon, CREST syndrome, microcirculatory disturbances, intermittent claudication, and peripheral and autonomous neuropathies.Type: GrantFiled: December 19, 2017Date of Patent: March 30, 2021Assignee: BAYER PHARMA AKTIENGESELLSCHAFTInventors: Eva Maria Becker-Pelster, Philipp Buchgraber, Anja Buchmüller, Karen Engel, Volker Geiss, Andreas Göller, Herbert Himmel, Raimund Kast, Andreas Knorr, Dieter Lang, Gorden Redlich, Carsten Schmeck, Hanna Tinel, Frank Wunder
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Patent number: 10323020Abstract: The present application relates to novel substituted piperidinyltetrahydroquinolines, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of diabetic microangiopathies, diabetic ulcers on the extremities, in particular for promoting wound healing of diabetic foot ulcers, diabetic heart failure, diabetic coronary microvascular heart disorders, peripheral and cardial vascular disorders, thromboembolic disorders and ischaemias, peripheral circulatory disturbances, Raynaud's phenomenon, CREST syndrome, microcirculatory disturbances, intermittent claudication, and peripheral and autonomous neuropathies.Type: GrantFiled: December 19, 2017Date of Patent: June 18, 2019Assignee: BAYER PHARMA AKTIENGESELLSCHAFTInventors: Eva Maria Becker-Pelster, Philipp Buchgraber, Anja Buchmüller, Karen Engel, Volker Geiss, Andreas Göller, Herbert Himmel, Raimund Kast, Andreas Knorr, Dieter Lang, Gorden Redlich, Carsten Schmeck, Hanna Tinel, Frank Wunder
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Publication number: 20180141931Abstract: The present application relates to novel substituted piperidinyltetrahydroquinolines, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of diabetic microangiopathies, diabetic ulcers on the extremities, in particular for promoting wound healing of diabetic foot ulcers, diabetic heart failure, diabetic coronary microvascular heart disorders, peripheral and cardial vascular disorders, thromboembolic disorders and ischaemias, peripheral circulatory disturbances, Raynaud's phenomenon, CREST syndrome, microcirculatory disturbances, intermittent claudication, and peripheral and autonomous neuropathies.Type: ApplicationFiled: December 19, 2017Publication date: May 24, 2018Inventors: Eva Maria BECKER-PELSTER, Philipp BUCHGRABER, Anja BUCHMÜLLER, Karen ENGEL, Volker GEISS, Andreas GÖLLER, Herbert HIMMEL, Raimund KAST, Andreas KNORR, Dieter LANG, Gorden REDLICH, Carsten SCHMECK, Hanna TINEL, Frank WUNDER
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Publication number: 20180141930Abstract: The present application relates to novel substituted piperidinyltetrahydroquinolines, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of diabetic microangiopathies, diabetic ulcers on the extremities, in particular for promoting wound healing of diabetic foot ulcers, diabetic heart failure, diabetic coronary microvascular heart disorders, peripheral and cardial vascular disorders, thromboembolic disorders and ischaemias, peripheral circulatory disturbances, Raynaud's phenomenon, CREST syndrome, microcirculatory disturbances, intermittent claudication, and peripheral and autonomous neuropathies.Type: ApplicationFiled: December 19, 2017Publication date: May 24, 2018Inventors: Eva Maria Becker-Pelster, Philipp Buchgraber, Anja Buchmüller, Karen Engel, Volker Geiss, Andreas Göller, Herbert Himmel, Raimund Kast, Andreas Knorr, Dieter Lang, Gorden Redlich, Carsten Schmeck, Hanna Tinel, Frank Wunder
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Patent number: 9944621Abstract: The present application relates to novel substituted piperidinyltetrahydroquinolines, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of diabetic microangiopathies, diabetic ulcers on the extremities, in particular for promoting wound healing of diabetic foot ulcers, diabetic heart failure, diabetic coronary microvascular heart disorders, peripheral and cardial vascular disorders, thromboembolic disorders and ischaemias, peripheral circulatory disturbances, Raynaud's phenomenon, CREST syndrome, microcirculatory disturbances, intermittent claudication, and peripheral and autonomous neuropathies.Type: GrantFiled: December 16, 2014Date of Patent: April 17, 2018Assignee: BAYER PHARMA AKTIENGESELLSCHAFTInventors: Eva Maria Becker-Pelster, Philipp Buchgraber, Anja Buchmüller, Karen Engel, Volker Geiss, Andreas Göller, Herbert Himmel, Raimund Kast, Andreas Knorr, Dieter Lang, Gorden Redlich, Carsten Schmeck, Hanna Tinel, Frank Wunder
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Patent number: 9624199Abstract: The invention relates to novel substituted bipiperidinyl derivatives, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of diabetic microangiopathies, diabetic ulcers on the extremities, in particular for promoting wound healing of diabetic foot ulcers, diabetic heart failure, diabetic coronary microvascular heart disorders, peripheral and cardial vascular disorders, thromboembolic disorders and ischaemias, peripheral circulatory disturbances, Raynaud's phenomenon, CREST syndrome, microcirculatory disturbances, intermittent claudication, and peripheral and autonomous neuropathies.Type: GrantFiled: December 16, 2014Date of Patent: April 18, 2017Assignee: Bayer Pharma AktiengesellschaftInventors: Eva Maria Becker-Pelster, Philipp Buchgraber, Anja Buchmüller, Karen Engel, Andreas Göller, Herbert Himmel, Raimund Kast, Joerg Keldenich, Carsten Schmeck, Hanna Tinel, Frank Wunder
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Patent number: 9624198Abstract: The present application relates to novel substituted piperidinyltetrahydroquinolines, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of diabetic microangiopathies, diabetic ulcers on the extremities, in particular for promoting wound healing of diabetic foot ulcers, diabetic heart failure, diabetic coronary microvascular heart disorders, peripheral and cardial vascular disorders, thromboembolic disorders and ischaemias, peripheral circulatory disturbances, Raynaud's phenomenon, CREST syndrome, microcirculatory disturbances, intermittent claudication, and peripheral and autonomous neuropathies.Type: GrantFiled: December 16, 2014Date of Patent: April 18, 2017Assignee: Bayer Pharma AktiengesellschaftInventors: Eva Maria Becker-Pelster, Philipp Buchgraber, Anja Buchmüller, Karen Engel, Volker Geiss, Andreas Göller, Herbert Himmel, Raimund Kast, Andreas Knorr, Dieter Lang, Gorden Redlich, Carsten Schmeck, Hanna Tinel, Frank Wunder
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Patent number: 9493472Abstract: The invention relates to substituted benzoxazoles and to processes for their preparation and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of cardiovascular disorders, preferably of thrombotic or thromboembolic disorders.Type: GrantFiled: May 30, 2014Date of Patent: November 15, 2016Assignee: Bayer Pharma AktiengesellschaftInventors: Swen Allerheiligen, Anja Buchmüller, Karen Engel, Christoph Gerdes, Kersten Matthias Gericke, Michael Gerisch, Stefan Heitmeier, Alexander Hillisch, Tom Kinzel, Philip Lienau, Bernd Riedl, Susanne Röhrig, Martina Victoria Schmidt, Julia Strassburger, Adrian Tersteegen
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Publication number: 20160318901Abstract: The present application relates to novel substituted piperidinyltetrahydroquinolines, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of diabetic microangiopathies, diabetic ulcers on the extremities, in particular for promoting wound healing of diabetic foot ulcers, diabetic heart failure, diabetic coronary microvascular heart disorders, peripheral and cardial vascular disorders, thromboembolic disorders and ischaemias, peripheral circulatory disturbances, Raynaud's phenomenon, CREST syndrome, microcirculatory disturbances, intermittent claudication, and peripheral and autonomous neuropathies.Type: ApplicationFiled: December 16, 2014Publication date: November 3, 2016Applicant: Bayer Pharma AktiengesellschaftInventors: Eva Maria BECKER-PELSTER, Philipp BUCHGRABER, Anja BUCHMÜLLER, Karen ENGEL, Volker GEISS, Andreas GÖLLER, Herbert HIMMEL, Raimund KAST, Andreas KNORR, Dieter LANG, Gorden REDLICH, Carsten SCHMECK, Hanna TINEL, Frank WUNDER
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Publication number: 20160318866Abstract: The invention relates to novel substituted bipiperidinyl derivatives, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of diabetic microangiopathies, diabetic ulcers on the extremities, in particular for promoting wound healing of diabetic foot ulcers, diabetic heart failure, diabetic coronary microvascular heart disorders, peripheral and cardiac vascular disorders, thromboembolic disorders and ischaemias, peripheral circulatory disturbances, Raynaud's phenomenon, CREST syndrome, microcirculatory disturbances, intermittent claudication, and peripheral and autonomous neuropathies.Type: ApplicationFiled: December 16, 2014Publication date: November 3, 2016Applicant: Bayer Pharma AktiengesellschaftInventors: Eva Maria BECKER-PELSTER, Philipp BUCHGRABER, Anja BUCHMÜLLER, Karen ENGEL, Mark Jean GNOTH, Herbert HIMMEL, Raimund KAST, Joerg KELDENICH, Jürgen KLAR, Andreas KNORR, Dieter LANG, Niels LINDNER, Carsten SCHMECK, Rudolf SCHOHE-LOOP, Hanna TINEL, Hubert TRÜBEL, Frank WUNDER
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Publication number: 20160304492Abstract: The invention relates to novel substituted bipiperidinyl derivatives, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of diabetic microangiopathies, diabetic ulcers on the extremities, in particular for promoting wound healing of diabetic foot ulcers, diabetic heart failure, diabetic coronary microvascular heart disorders, peripheral and cardial vascular disorders, thromboembolic disorders and ischaemias, peripheral circulatory disturbances, Raynaud's phenomenon, CREST syndrome, microcirculatory disturbances, intermittent claudication, and peripheral and autonomous neuropathies.Type: ApplicationFiled: December 16, 2014Publication date: October 20, 2016Applicant: Bayer Pharma AktiengesellschaftInventors: Eva Maria BECKER-PELSTER, Philipp BUCHGRABER, Anja BUCHMÜLLER, Karen ENGEL, Andreas GÖLLER, Herbert HIMMEL, Raimund KAST, Joerg KELDENICH, Carsten SCHMECK, Hanna TINEL, Frank WUNDER
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Publication number: 20160304491Abstract: The present application relates to novel substituted piperidinyltetrahydroquinolines, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of diabetic microangiopathies, diabetic ulcers on the extremities, in particular for promoting wound healing of diabetic foot ulcers, diabetic heart failure, diabetic coronary microvascular heart disorders, peripheral and cardial vascular disorders, thromboembolic disorders and ischaemias, peripheral circulatory disturbances, Raynaud's phenomenon, CREST syndrome, microcirculatory disturbances, intermittent claudication, and peripheral and autonomous neuropathies.Type: ApplicationFiled: December 16, 2014Publication date: October 20, 2016Applicant: Bayer Pharma AktiengesellschaftInventors: Eva Maria BECKER-PELSTER, Philipp BUCHGRABER, Anja BUCHMÜLLER, Karen ENGEL, Volker GEISS, Andreas GÖLLER, Herbert HIMMEL, Raimund KAST, Andreas KNORR, Dieter LANG, Gorden REDLICH, Carsten SCHMECK, Hanna TINEL, Frank WUNDER
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Patent number: 9422263Abstract: The present invention relates to novel fluoro-substituted 3,5-dicyano-4-(1H-indazol-5-yl)-2,6-dimethyl-1,4-dihydropyridine derivatives having protein tyrosine kinase inhibitory activity, to a process for the manufacture thereof and to the use thereof for the treatment of c-Met-mediated diseases or c-Met-mediated conditions, particularly cancer and other proliferative disorders.Type: GrantFiled: October 1, 2010Date of Patent: August 23, 2016Assignee: BAYER PHARMA AKTIENGESELLSCHAFTInventors: Martin Michels, Markus Follmann, Alexandros Vakalopoulos, Katja Zimmermann, Nicole Teusch, Mario Lobell, Donald Bierer, Karen Engel, Maria Kissel
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Publication number: 20160137647Abstract: The invention relates to substituted benzoxazoles and to processes for their preparation and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of cardiovascular disorders, preferably of thrombotic or thromboembolic disorders.Type: ApplicationFiled: May 30, 2014Publication date: May 19, 2016Inventors: Swen ALLERHEILlGEN, Anja BUCHMÜLLER, Karen ENGEL, Christoph GERDES, Kersten Matthias GERICKE, Michael GERISCH, Stefan HEITMEIER, Alexander HILLlSCH, Tom KINZEL, Philip LIENAU, Bernd RIEDL, Susanne RÖHRIG, Martina Victoria SCHMIDT, Julia STRASSBURGER, Adrian TERSTEEGEN
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Publication number: 20160108027Abstract: The invention relates to substituted benzoxazoles and to processes for their preparation and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of cardiovascular disorders, preferably of thrombotic or thromboembolic disorders.Type: ApplicationFiled: May 30, 2014Publication date: April 21, 2016Inventors: Swen ALLERHEILlGEN, Anja BUCHMÜLLER, Karen ENGEL, Christoph GERDES, Kersten Matthias GERICKE, Michael GERISCH, Stefan HEITMEIER, Alexander HILLlSCH, Tom KINZEL, Philip LIENAU, Bernd RIEDL, Susanne RÖHRIG, Martina Victoria SCHMIDT, Julia STRASSBURGER, Adrian TERSTEEGEN
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Publication number: 20160108039Abstract: The invention relates to substituted triazolopyridines and to processes for their preparation and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of cardiovascular disorders, preferably of thrombotic or thromboembolic disorders.Type: ApplicationFiled: June 2, 2014Publication date: April 21, 2016Inventors: Swen ALLERHEILlGEN, Anja BUCHMÜLLER, Karen ENGEL, Christoph GERDES, Kersten Matthias GERICKE, Michael GERISCH, Stefan HEITMEIER, Alexander HILLlSCH, Tom KINZEL, Philip LIENAU, Bernd RIEDL, Susanne RÖHRIG, Martina Victoria SCHMIDT, Julia STRASSBURGER, Adrian TERSTEEGEN
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Patent number: 9018234Abstract: The present invention relates to novel, fluoro-substituted 2-aryl-3,5-dicyano-4-(1H-indazol-5-yl)-6-methyl-1,4-dihydropyridine derivatives having protein tyrosine kinase inhibitory activity, to a process for the manufacture thereof and to the use thereof for the treatment of c-Met-mediated diseases or c-Met-mediated conditions, particularly Cancer and other proliferative disorders.Type: GrantFiled: November 8, 2010Date of Patent: April 28, 2015Assignee: Bayer Intellectual Property GmbHInventors: Alexandros Vakalopoulos, Martin Michels, Katja Zimmermann, Nicole Teusch, Mario Lobell, Karen Engel
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Patent number: 8642595Abstract: This invention relates to novel annellated 4-(indazolyl)-1,4-dihydropyridine derivatives having protein tyrosine kinase inhibitory activity, to a process for the manufacture thereof and to the use thereof for the treatment of c-Met-mediated diseases or c-Met-mediated conditions, particularly cancer and other proliferative disorders.Type: GrantFiled: May 29, 2009Date of Patent: February 4, 2014Assignee: Bayer Intellectual Property GmbHInventors: Martin Michels, Markus Follmann, Alexandros Vakalopoulos, Katja Zimmermann, Nicole Teusch, Karen Engel
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Patent number: 8551989Abstract: This invention relates to novel 4-(indazolyl)-1,4-dihydropyridine of the following formula (I) derivatives having protein tyrosine kinase inhibitory activity, to a process for the manufacture thereof and to the use thereof for the treatment of c-Met-mediated diseases or c-Met-mediated conditions, particularly cancer and other proliferative disorders.Type: GrantFiled: May 29, 2009Date of Patent: October 8, 2013Assignee: Bayer Intellectual Property GmbHInventors: Martin Michels, Markus Follmann, Alexandros Vakalopoulos, Katja Zimmermann, Nicole Teusch, Karen Engel
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Publication number: 20130005773Abstract: The present invention relates to novel, fluoro-substituted 2-aryl-3,5-dicyano-4-(1H-indazol-5-yl)-6-methyl-1,4-dihydropyridine derivatives having protein tyrosine kinase inhibitory activity, to a process for the manufacture thereof and to the use thereof for the treatment of c-Met-mediated diseases or c-Met-mediated conditions, particularly Cancer and other proliferative disorders.Type: ApplicationFiled: November 8, 2010Publication date: January 3, 2013Applicant: BAYER INTELLECTUAL PROPERTY GMBHInventors: Alexandros Vakalopoulos, Martin Michels, Katja Zimmermann, Nicole Teusch, Mario Lobell, Karen Engel