Patents by Inventor Karen F. Deutsch
Karen F. Deutsch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5690908Abstract: Treated apatite particles are disclosed for enhancing medical diagnostic imaging such as magnetic resonance imaging ("MRI"), magnetic resonance spectroscopy ("MRS"), magnetic resonance spectroscopy imaging ("MRSI"), X-ray diagnostic imaging, and ultrasound imaging. Novel coating and manufacturing techniques are disclosed to control particle size and particle aggregation resulting in compositions for organ specific imaging of the liver, spleen, gastrointestinal tract, or tissue disease states is obtained. Depending on the diagnostic imaging technique, apatite particles are treated to be paramagnetic, radiopaque, or echogenic. The apatite particles may also be fluorinated to form stable fluoroapatite compositions useful for .sup.19 F imaging.Type: GrantFiled: November 13, 1995Date of Patent: November 25, 1997Assignee: Mallinckrodt Medical, Inc.Inventors: Edward A. Deutsch, Karen F. Deutsch, William P. Cacheris, William H. Ralston, David H. White, Dennis L. Nosco, Robert G. Wolfangel, Janet Braddock Wilking, Linda Meeh, Steven R. Woulfe
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Patent number: 5609850Abstract: Treated apatite particles are disclosed for enhancing radical diagnostic imaging such as magnetic resonance imaging ("MRI"), magnetic resonance spectroscopy ("MRS"), magnetic resonance spectroscopy imaging ("MRSI"), X-ray diagnostic imaging, and ultrasound imaging. Novel coating and manufacturing techniques are disclosed to control particle size and particle aggregation resulting in compositions for organ specific imaging of the liver, spleen, gastrointestinal tract, or tissue disease states is obtained. Depending on the diagnostic imaging technique, apatite particles are treated to be paramagnetic, radiopaque, or echogenic. The apatite particles may also be fluorinated to form stable fluoroapatite compositions useful for .sup.19 F imaging.Type: GrantFiled: August 22, 1995Date of Patent: March 11, 1997Assignee: Mallinckrodt Medical, Inc.Inventors: Edward A. Deutsch, Karen F. Deutsch, William P. Cacheris, William H. Ralston, David H. White, Dennis L. Nosco, Robert G. Wolfangel, Janet B. Wilking, Linda Meeh, Steven R. Woulfe
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Patent number: 5595724Abstract: Treated calcium/oxyanion-containing particles are disclosed for enhancing medical diagnostic imaging such as magnetic resonance imaging ("MRI"), magnetic resonance spectroscopy ("MRS"), magnetic resonance spectroscopy imaging ("MRSI"), X-ray diagnostic imaging, and ultrasound imaging. Novel coating and manufacturing techniques are disclosed to control particle size and particle aggregation resulting in compositions for organ specific imaging of the liver, spleen, or tissue disease states is obtained. Depending on the diagnostic imaging technique, calcium/oxyanion-containing particles are treated to be paramagnetic, radiopaque, or echogenic. Also disclosed are diagnostic compositions and methods of performing medical diagnostic procedures which involve administering to a warm-blooded animal a diagnostically effective amount of the above-described particles and then performing the medical diagnostic procedure.Type: GrantFiled: January 13, 1995Date of Patent: January 21, 1997Inventors: Edward A. Deutsch, Karen F. Deutsch, Dennis L. Nosco, William H. Ralston, David H. White, Janet B. Wilking, Robert G. Wolfangel, Steven R. Woulfe, William P. Cacheris, Linda Meeh
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Patent number: 5560901Abstract: The present invention provides radiation synovectomy compositions for treating inflamed synovium containing a radionuclide complex bound to a hydroxyapatite-like matrix as the radiolabelled synovectomy agent in a sufficient amount to provide satisfactory synovectomy of the inflamed synovium together with a pharmaceutically acceptable vehicle, the radionuclide being a beta emitter that will substantially ablate the inflamed synovium, but not significantly damage underlying articular cartilage, the radionuclide complex being substantially kinetically stable, and if said radionuclide or radionuclide complex leaks from said joint it will be excreted from the body, the agent having a particle size such that there is essentially little or no leakage of the radionuclide complex from the joint after administration.Type: GrantFiled: March 21, 1994Date of Patent: October 1, 1996Assignee: Mallinckrodt Medical, Inc.Inventors: James W. Brodack, Edward A. Deutsch, Karen F. Deutsch, Dennis L. Nosco
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Patent number: 5468465Abstract: Treated apatite particles are disclosed for enhancing medical diagnostic imaging such as magnetic resonance imaging ("MRI"), magnetic resonance spectroscopy ("MRS"), magnetic resonance spectroscopy imaging (37 MRSI"), X-ray diagnostic imaging, and ultrasound imaging. Novel coating and manufacturing techniques are disclosed to control particle size and particle aggregation resulting in compositions for organ specific imaging of the liver, spleen, gastrointestinal tract, or tissue disease states is obtained. Depending on the diagnostic imaging technique, apatite particles are treated to be paramagnetic, radiopaque, or echogenic. The apatite particles may also be fluorinated to form stable fluoroapatite compositions useful for .sup.19 F imaging.Type: GrantFiled: July 6, 1994Date of Patent: November 21, 1995Assignee: Mallinckrodt Medical, Inc.Inventors: Edward A. Deutsch, Karen F. Deutsch, William P. Cacheris, William H. Ralston, David H. White, Dennis L. Nosco, Robert G. Wolfangel, Janet B. Wilking, Linda Meeh, Steven R. Woulfe
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Patent number: 5417958Abstract: The present invention relates to novel compounds for use as imaging agents. In particular, the present invention relates to imaging agents comprising a heavy metal cluster having 2 to 8 atoms of the same of different heavy metal elements, and at least one coordinating ligand having 1 to 8 atoms which bond to the cluster, and a number of supporting atoms making up the framework of the ligand.Type: GrantFiled: February 2, 1994Date of Patent: May 23, 1995Assignee: Mallinckrodt Medical, Inc.Inventors: Edward A. Deutsch, Karen F. Deutsch, Dennis L. Nosco
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Patent number: 5407659Abstract: Treated calcium/oxyanion-containing particles are disclosed for enhancing medical diagnostic imaging such as magnetic resonance imaging ("MRI"), magnetic resonance spectroscopy ("MRS"), magnetic resonance spectroscopy imaging ("MRSI"), X-ray diagnostic imaging, and ultrasound imaging. Novel coating and manufacturing techniques are disclosed to control particle size and particle aggregation resulting in compositions for organ specific imaging of the liver, spleen, or tissue disease states is obtained. Depending on the diagnostic imaging technique, calcium/oxyanion-containing particles are treated to be paramagnetic, radiopaque, or echogenic. Also disclosed are diagnostic compositions and methods of performing medical diagnostic procedures which involve administering to a warm-blooded animal a diagnostically effective amount of the above-described particles and then performing the medical diagnostic procedure.Type: GrantFiled: April 13, 1993Date of Patent: April 18, 1995Assignee: Mallinckrodt Medical, Inc.Inventors: Edward A. Deutsch, Karen F. Deutsch, Dennis L. Nosco, William H. Ralston, David H. White, Janet B. Wilking, Robert G. Wolfangel, Steven R. Woulfe
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Patent number: 5344640Abstract: Treated apatite particles are disclosed for enhancing medical diagnostic imaging such as magnetic resonance imaging ("MRI"), magnetic resonance spectroscopy ("MRS"), magnetic resonance spectroscopy imaging ("MRSI"), X-ray diagnostic imaging, and ultrasound imaging. Novel coating and manufacturing techniques are disclosed to control particle size and particle aggregation resulting in compositions for organ specific imaging of the liver, spleen, gastrointestinal tract, or tissue disease states is obtained. Depending on the diagnostic imaging technique, apatite particles are treated to be paramagnetic, radiopaque, or echogenic. The apatite particles may also be fluorinated to form stable fluoroapatite compositions useful for .sup.19 F imaging.Type: GrantFiled: September 22, 1992Date of Patent: September 6, 1994Assignee: Mallinckrodt Medical, Inc.Inventors: Edward A. Deutsch, Karen F. Deutsch, William P. Cacheris, William H. Ralston, David H. White, Dennis L. Nosco, Robert G. Wolfangel, Janet B. Wilking, Linda Meeh, Steven R. Woulfe
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Patent number: 5320824Abstract: The present invention provides radiation synovectomy compositions for treating inflamed synovium containing a radionuclide complex bound to a substantially insoluble particle as the radiolabelled synovectomy agent in a sufficient amount of provide satisfactory synovectomy of the inflamed synovium together with a pharmaceutically acceptable vehicle, the radionuclide being a beta emitter that will substantially ablate the inflamed synovium, but not significantly damage underlying articular cartilage, the radionuclide complex being substantially kinetically stable, and if said radionuclide or radionuclide complex leaks from said joint it will be excreted from the body, the agent having a particle size such that there is essentially little or no leakage of the radionuclide complex from the joint after administration.Type: GrantFiled: April 16, 1993Date of Patent: June 14, 1994Assignee: Mallinckrodt Medical, Inc.Inventors: James W. Brodack, Edward A. Deutsch, Karen F. Deutsch, Dennis L. Nosco