Patents by Inventor Karen F. Lech

Karen F. Lech has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Assays for inhibitors of myc oncoprotein
    Patent number: 5580721
    Abstract: A method for the identification of compounds as inhibitors of oncoprotein action is described. A compound is identified as an inhibitor of oncoprotein action based on its ability to modulate the transcription of a reporter gene. Transcription of the reporter gene is dependent upon the binding of a fusion oncoprotein to a specific DNA binding element positioned upstream of the reporter gene promoter. The fusion oncoprotein contains a transcriptional regulatory domain from an oncoprotein and a DNA binding domain from a different protein.
    Type: Grant
    Filed: October 7, 1993
    Date of Patent: December 3, 1996
    Assignee: The General Hospital Corporation
    Inventors: Roger Brent, Erica Golemis, Karen F. Lech, Catherine Anderson