Abstract: The invention discloses a method for identifying a subset of polynucleotides from an initial set of polynucleotides corresponding to the human genome for the in vitro determination of severity of the host response of a patient having a severe infectious and/or inflammatory condition, in a sample, a measuring device comprising a plurality of different gene probes which represent the entire human genome, the test persons, depending on their infectious and/or inflammatory status, are divided into at least two clinically determined phenotype groups, changes of the gene expression signals between the phenotype groups are compared statistically, and gene probes are selected based on the gene expression signals which have significantly changed statistically between at least two phenotype groups.

Abstract: The present invention relates to a method for separating, determining or accumulating different DNA species that are present simultaneously in a sample, on the basis of unmethylated CpG-dinucleotides occurring with different frequency, within each DNA species present, wherein an unmethylated CpG motifs binding protein is immobilized on a base material and the DNA bound to the immobilized protein is eluted using an elution agent gradient, wherein specific concentration regions of the elution agent used correlate with specific CpG-dinucleotide frequencies in the DNA species present, so that during elution different fractions of DNA species are obtained that have different frequencies of CpG-dinucleotides.